Archive of European Projects

Over 40 European Projects Found

Searched on 125080 European Projects

 ONGOING 
Plasmodium vivax is the most widespread malaria and constitutes a significant proportion of human malaria cases. P. vivax accounts for 100-400 million clinical cases each year among the 2.5 billion people living at risk in Latin America, Oceania and Asia. The recently revised Malaria Vaccine Technology Roadmap to 2030 recognises the severity of P. vivax malaria and calls for a vaccine intervention ...
Read Project

 9

 ONGOING 

Optimizing a deployable high efficacy malaria vaccine (OptiMalVax)

Start date: 01 Jan 2017, End date: 31 Dec 2021,

A highly effective malaria vaccine against Plasmodium falciparum should help prevent half a million deaths from malaria each year. New vaccine technologies and antigen discovery approaches now make accelerated design and development of a highly effective multi-antigen multi-stage subunit vaccine feasible. Leading malariologists, vaccine researchers and product developers will here collaborate in ...
Read Project

 17

 ONGOING 
PACE aims to transform the treatment of patients suffering from critical limb ischemia (CLI), a disease with high medical need, because of limited treatment options and poor outcome by applying a novel, off-the-shelf allogeneic placenta-derived stromal cell product (PLX-PAD). Despite improvements in medical care and revascularization, patients with CLI continue to have a high risk of major amputat ...
Read Project

 9

 ONGOING 
The INFRAFRONTIER RI integrates European Mouse Clinics and the European Mouse Mutant Archive with the common goal to ensure access to mouse models for basic research of human health and disease, and to translate this knowledge into therapeutic approaches for the benefit of the European society. The expanded INFRAFRONTIER2020 network, coordinated by the INFRAFRONTIER GmbH, includes 3 SMEs and is st ...
Read Project

 33

 ONGOING 
... utic relevance that promote BAT development and/or activation/recruitment using a stem cell based BAT differentiation approach, and then to functionally validate the role of these factors in vitro by genome engineering human stem cell derived adipocytes and in vivo by transplanting these cells into mice. Specific Aims are: 1.To identify molecular mechanisms involved in human brown adipose tissue d ...
Read Project

 2

 ONGOING 

European AIDS Vaccine Initiative 2020 (EAVI2020)

Start date: 01 Nov 2015, End date: 31 Oct 2020,

HIV-1 is responsible for a global pandemic of 35 million people, and continues to spread at a rate of >2 million new infections/year. It is widely acknowledged that a protective vaccine would be the most effective means to reduce HIV-1 spread and ultimately eliminate the pandemic, while a therapeutic vaccine may help mitigate the clinical course of disease and lead to strategies of viral eradicati ...
Read Project

 27

 ONGOING 
Traumatic Brain Injury (TBI) is a major cause of death and disability, leading to great personal suffering to victim and relatives, as well as huge direct and indirect costs to society. Strong ethical, medical, social and health economic reasons therefore exist for improving treatment. The CENTER-TBI project will collect a prospective, contemporary, highly granular, observational dataset of 5400 p ...
Read Project

 44

 ONGOING 
COMPARE aims to harness the rapid advances in molecular technology to improve identification and mitigation of emerging infectious diseases and foodborne outbreaks. To this purpose COMPARE will establish a “One serves all” analytical framework and data exchange platform that will allow real time analysis and interpretation of sequence-based pathogen data in combination with associated data (e.g. c ...
Read Project

 32

 ONGOING 
... f TEN beneficiaries combines T cell expertise with state-of-the-art technologies such as next generation sequencing (NGS), bioinformatics, multi-colour flow cytometry, preclinical models and tailored genome editing. Trainees will acquire a comprehensive knowledge in T cell immunology and the capacity to generate and interrogate big data sets as well as expertise in identifying novel biomarkers and ...
Read Project

 11

 ONGOING 
The IPAD-MD project addresses cooperation and coordination between the pan-European INFRAFRONTIER Research Infrastructure and complementary research infrastructures in America, Asia and Australia, contributing to the global effort of the International Mouse Phenotyping Consortium (IMPC). In order to increase the reach of INFRAFRONTIER, IPAD-MD will also reach out to complementary infrastructures a ...
Read Project

 11

 ONGOING 
MELGEN (MELanoma GENetics) – understanding and biomarking the genetic and immunological determinants of melanoma survivalThe MELGEN European Training Network (ETN) will create an environment for long-term, collaborative, inter-sectorial cancer genetics research with the ultimate aim of improving precision (personalised) medicine. In a 2012 report the European Science Foundation identified the impo ...
Read Project

 7

 ONGOING 

Combination therapies for personalized cancer medicine (COMBATCANCER)

Start date: 01 May 2013, End date: 30 Apr 2019,

All cancers arise due to alterations in their genomes. Although insight into the genetic lesions in tumours by genome sequencing does already assist in selecting some drug regimens, it rarely results in disease eradication due to the emergence of drug-resistant clones. More sophisticated combination therapies in which several oncogenic pathways are targeted simultaneously or in a particular seque ...
Read Project

 2

 FINISHED 
... the scope of the landmark ENCODE and FANTOM projects. ENCODE highlighted the need for an in vivo vertebrate model that enables high throughput in vivo functional testing of hypotheses generated from genome scale annotation. Zebrafish is an ideal model for extending the scope of genomics to vertebrate development. We aim to comprehensively annotate functional elements, decipher genomic codes of t ...
Read Project

 11

 FINISHED 
MRG-GRammar aims to devise an entirely new strategy for deciphering the regulatory rules of gene regulation. We will leverage Synthetic Biology with cutting-edge DNA synthesis technologies and high-throughput analysis to generate new types of biological datasets that systematically explore all possible regulatory landscapes rather than just the naturally occurring regulatory sequences. The extensi ...
Read Project

 7

 FINISHED 
Whipworms (Trichuris trichuira) are soil-transmitted helminths that infect about 700 million people in the tropics and sub-tropics and cause the human disease, trichuriasis. Whipworms live preferentially in the cecum of their hosts where they tunnel through epithelial cells and cause inflammation potentially resulting in colitis. Despite extensive research, the role of whipworm interactions with e ...
Read Project

 1

 FINISHED 

Sequencing population isolates to find complex trait loci (SEPI)

Start date: 01 Jun 2012, End date: 31 May 2017,

"Genome-wide association studies of complex traits have identified many common variant associations, but a substantial heritability gap remains. The field is shifting towards the study of low frequency and rare variants, hypothesised to have larger effects. The study of these variants can be empowered by focusing on isolated populations, in which rare variants may have increased in frequency and l ...
Read Project

 1

 FINISHED 
To contribute to the development of vaccines against Shigella and ETEC for children of the developing world, STOPENTERICS will provide novel solutions by imposing a two-fold paradigm switch: (i) to break the dogma of serotype-specificity by inducing a cross-protective immunity (ii) to improve the immunogenicity of Shigella glycoconjugates by using synthetic oligosacharides mimicking the lipopolysa ...
Read Project

 20

 FINISHED 
The magnitude of cancer risk in humans exposed to low radiation doses (
Read Project

 16

 FINISHED 
Migraine is a common brain disorder, typically characterised by recurring, incapacitating attacks of 1-3 days of severe headache, autonomic dysfunction, and sometimes aura symptoms. The disease affects 15% of all European citizens including children, ranks among the WHO top 12 of most disabling and undertreated disorders, and is responsible for the highest socio-economic burden of any brain ailmen ...
Read Project

 14

 FINISHED 

BBMRI - Large Prospective Cohorts (BBMRI-LPC)

Start date: 01 Feb 2013, End date: 31 Jan 2017,

... samples and data;4)Provide free transnational access by users, through study proposals selected by an open, pan-European call;5)In the framework of these studies, generate and provide access to whole genome sequences, transcriptome, proteome, metabolome and methylome data;6)Build new public-private partnerships involving large-scale prospective cohorts, and strengthening existing ones, allowing tr ...
Read Project

 36

 FINISHED 

Genetic and physiological basis of thinness (STILTS)

Start date: 01 Jan 2012, End date: 31 Dec 2016,

"The rising prevalence of obesity and associated co-morbidities such as Type 2 diabetes, cardiovascular disease and certain cancers represents a major threat to public health in Europe and worldwide. It can be argued that modern westernized environments are obesity promoting due to unprecedented economic growth, decreased incidence of infectious disease, nearly unlimited food supply, a wide availa ...
Read Project

 2

 FINISHED 

European Bank for induced pluripotent Stem Cells (EBISC)

Start date: 01 Jan 2014, End date: 31 Dec 2016,

EBiSC is designed to address the increasing demand by iPSC researchers for quality-controlled, disease-relevant research grade iPSC lines, data and cell services. Its goal is to demonstrate an operational banking and distribution service of iPSC lines after 3 years and to establish subsequently for Europe a centralised, not-for-profit bank providing all qualified users with access to scalable, cos ...
Read Project

 30

 FINISHED 
We propose here an exhaustive analysis of the genome, exome, methylome and transcriptome of primary tumours and metastases from patients with colon carcinoma, based on a combination of deep sequencing and chip based techniques. Dependent on their availability, we shall also perform analyses of tumor stem cells, circulating tumor cells, free tumor DNA in serum and xenografts derived from the same p ...
Read Project

 22

 FINISHED 
... makes it a key model for research into human disease. The major challenges for mouse functional genomics in the 21st century are to:• Develop a series of mutant alleles for every gene in the mouse genome• Determine the phenotypic consequences of each mutation• Identify mouse models for the complete disease spectrum in humansTo further develop and exploit the emerging mouse mutant resource, mouse ...
Read Project

 24

 FINISHED 
Colorectal cancer (CRC) was diagnosed in 1.23 million people worldwide (EU 333,000) in 2008 and 608,000 (EU 148,000) died of the disease. While some new treatments have been advanced in CRC many have failed clinical testing; metastatic CRC is still largely incurable.In CRC, Cancer Stem Cells (CSC) are responsible for tumour progression and resistant to standard chemotherapies. The Wnt signal trans ...
Read Project

 5

 FINISHED 
... on, and through training of Central Asian researchers in centres of excellence in Europe. We shall address the limited knowledge of genetic diversity in Central Asian populations by undertaking whole genome sequencing, analogous to the 1000 Genomes project. We will establish the first pre-eclampsia biobanks of DNA and plasma samples from a total of 4000 affected women, their partners and babies, a ...
Read Project

 13

 FINISHED 

A BLUEPRINT of Haematopoietic Epigenomes (BLUEPRINT)

Start date: 01 Oct 2011, End date: 30 Sep 2016,

In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and o ...
Read Project

 45

 FINISHED 
... rug-resistance genes and consequently to develop new effective combination therapies by a data-driven approach.I will screen a library of drugs across a collection of EMCCs and in concert analyze the genome of each EMCC for mutations, epimutations and chromosomal aberrations. EMCCs found to be intrinsically resistant to a given drug will be screened with a short-hairpin-RNA library to identify gen ...
Read Project

 1

 FINISHED 
Osteoporotic bone loss due to aging or disease is a major health issue that affects hundreds of millions of people worldwide and costs tens of billions of euros each year. Since current osteoporosis medication only reduces fracture risk by 25-50%, there is an urgent need to define new pathways that control bone remodelling and strength in order to identify new therapeutic targets. Via the ‘Mouse G ...
Read Project

 1

 FINISHED 

Epigenetics towards systems biology (EPIGENESYS)

Start date: 01 Oct 2010, End date: 31 Mar 2016,

... dynamics of epigenetic systems at the single molecule and cell level, 2) linking genotypes to epigenotypes, 3) investigating how environmental, developmental and metabolic signals act upon the epigenome, and 4) understanding epigenetic inheritance through replication, mitosis and meiosis. The common objective is to address fundamental epigenetic mechanisms in quantitative terms both spatially and ...
Read Project

 28

 FINISHED 

Zebrafish Regulomics for Human Health (ZF-HEALTH)

Start date: 01 Jul 2010, End date: 31 Dec 2015,

... Complementing the study of mutants relevant for neurological disorders, we will produce an atlas of gene expression in the brain, the most comprehensive one in a vertebrate. We will further perform a genome-wide characterisation of regulatory elements of potential disease genes by a combination of bioinformatics and transgenics. Small-molecule screening for mutant rescue or disease-relevant proces ...
Read Project

 20

 FINISHED 
Over the past 15 years, EU-funded cohorts and collaborations (EuroSIDA, CASCADE and PENTA), have played a central role in developing our understanding of HIV progression and the effects of ART, enabling European expertise to contribute directly to the advances in patient diagnosis and management worldwide, and providing a continued surveillance mechanism for detection of emerging problems at a Eur ...
Read Project

 26

 FINISHED 

Systems Biology of Stem Cells and Reprogramming (SyBoSS)

Start date: 01 Jun 2010, End date: 30 Nov 2015,

Stem cells are central to emerging concepts in health, medicine and therapy. The realization that specific cell reservoirs retain multipotency for tissue establishment and replenishment has implications for both the emerging field of regenerative therapy and the long standing problems of cancer, ageing and degenerative diseases. Recently the prospects for regenerative therapy have been boosted by ...
Read Project

 11

 FINISHED 
... n consortia which address mouse functional genomics, mouse mutant phenotyping, and mouse archiving.Taken together, EUCOMMTOOLS will further advance the functional annotation of the entire mouse genome and thereby enhance the understanding of the molecular basis of disease. Furthermore, it will support drug development by SMEs and the pharmaceutical industry.
Read Project

 11

 FINISHED 

European Sequencing and Genotyping Infrastructure (ESGI)

Start date: 01 Feb 2011, End date: 31 Jul 2015,

The objective of this project is the integration of world class high-throughput sequencing and genotyping facilities that will provide sequencing and genotyping technologies and data analysis methodologies to the scientific community.The European Sequencing and Genotyping Infrastructure (ESGI) will enable external users to generate data rapidly and to acquire knowledge efficiently. By providing ac ...
Read Project

 11

 FINISHED 

Genetic and Epigenetic Networks in Cognitive Dysfunction (GENCODYS)

Start date: 01 May 2010, End date: 30 Apr 2015,

Mutations in about 400 different genes have been associated with Cognitive Disorders (CD), such as mental retardation, autism, neurodegenerative disorders, and psychiatric disorders. Whereas CD impose a major medical and socio-economical problem, there are no systematic studies that aim to provide insight into common mechanisms in CD. We propose a systems biology approach to gain insight into comm ...
Read Project

 15

 FINISHED 
"Somatic structural variation (i.e., those structural rearrangements arising in a tumour) is found in almost all cancer genomes studied in detail. Current next-generation sequencing (NGS) strategies allow the identification of genomic structural variation with an unprecedented base pair resolution, revealing a complex landscape of somatic rearrangements in several cancer types. The studies carried ...
Read Project

 1

 FINISHED 
This is a proposal from 55 partners from 36 institutes to form a NoE that will seek to integrate European malaria research that is directed towards a better understanding of the basic biology of the parasite, its vector and of the biology of the interactions between the parasite and both its mammalian host and vectors. All the member institutes and researchers have demonstrated both their excellen ...
Read Project

 40

 FINISHED 

Breast Cancer Somatic Genetics Study (BASIS)

Start date: 01 Jul 2010, End date: 31 Dec 2014,

"All cancers arise due to somatically acquired mutations in their genomes which alter the function of key cancer genes. Understanding these critical mutational events underlying cancer development is paramount for advancing prevention, early detection, monitoring and treatment of the disease. Breast cancer is the most common class of cancer diagnosed in women worldwide with more than one million c ...
Read Project

 16

 FINISHED 
Major disorders of the Central Nervous System (CNS) affect one in three people in the developed world, often seriously disable the affected individual, and together account for the single largest burden on the healthcare systems of the EU. Most of these disorders act at the neuronal synapse, a cellular organelle comprising in the order of 2000 proteins. Pleiotropy, cross-talk between proteins and ...
Read Project

 19