Search for European Projects

Over 40 European Projects Found

Searched on 125080 European Projects

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RADIOGENOMICS: Finding Genetic Functional Variants Through Fine Mapping (RADIOGENFF)

Start date: Apr 1, 2016, End date: Mar 31, 2018,

...genetics of toxicity following radiotherapy. Unintended damage to normal tissues can severely affect up to 5% of patients for years after completion of curative cancer radiotherapy. To date three Genome Wide Association Studies on radiation toxicity in prostate cancer patients have been performed. These studies have identified genetic loci associated with development of radiation-induced toxicity ...
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Defining the molecular basis of type 2 diabetes predisposition through targeted sequencing of the CREBBP-interacting gene network (T2DCREBBP)

Start date: May 1, 2013, End date: Apr 30, 2015,

...ropose to conduct aims to explore the overall contribution of the CREBBP interactome in T2D predisposition, through integration of existing and novel genetic data. The former is provided by extensive genome wide association (n~100,000 individuals), exome sequence (n~14,000) and exome chip (n~60,000) available to the host institution; the latter will be generated by the applicant through large-scal ...
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Mutational and Functional Analysis of the Melanoma Genome (MELGEN)

Start date: Oct 1, 2013, End date: Sep 30, 2018,

...interrogate the cancer genetic landscape. However, although ample genomic sequences are becoming available, so far these have only provided limited information concerning the complexity of the cancer genome. Furthermore, our understanding of the functional effects of identified mutations is hampered by the difficulty in comprehensively assessing their biological and biochemical effects in a physio ...
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Regulation of DNA damage responses at the replication fork (DDRegulation)

Start date: Jul 1, 2014, End date: Jun 30, 2019,

This project aims at delineating the regulatory signaling processes that enable cells to overcome DNA damage during DNA replication, a major challenge to the integrity of the genome as the normal replication machinery is unable to replicate past DNA lesions. This may result in collapse of the replication fork, potentially giving rise to gross genomic alterations. To mitigate this threat, all cells ...
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Artificial intelligence, branching processes and coalescent – Searching the Information from a genetic Cornucopia (ArSInformatiCa)

Start date: Oct 1, 2012, End date: Sep 30, 2014,

...ied out in two fields of information sciences: artificial intelligence (in particular machine learning) and distributed computer simulations applied to retrieval meaningful information from the whole-genome-scale variation data produced by high throughput genotyping technologies. In particular, the interest will be given to inherited predisposition to complex genetic diseases, including autoimmune ...
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Reconstructing gene family evolution in the ash genus (Fraxinus (FraxiFam)

Start date: Jul 1, 2015, End date: Jun 30, 2017,

Comparisons among whole genome sequences allow us to survey differences in gene content among organisms, and hypothesise patterns of gene gain and loss through evolution. Rates of gene flux appear to be surprisingly high, and many genes are unexpectedly unique to species (“orphan” genes). In plants, increasing evidence suggests that genome evolution has been shaped by multiple rounds of whole geno ...
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Epigenetics in Mental Disorders: The role of imprinting and methylation patterns in Attention Deficit Hyperactivity Disorder (ADHD) (EPIMEN)

Start date: Sep 1, 2014, End date: Aug 31, 2016,

...nal four satellite projects in collaboration with our: (1) clinical group (epigenetics and perinatal factors), (2) neurotargeting group (epigenetics in cell lines), (3) statistical genetics group (epigenome x genome interaction) and (4) animal studies group (epigenetics and stress). The proposal will not only shed light on etiology of ADHD, but also unite several European research groups (Germany, ...
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Pathways, ecological and genomic consequences of genome duplication in Arabidopsis arenosa, an overlooked diploid-polyploid member of the model genus Arabidopsis (WILD ARABIDOPSIS)

Start date: Sep 1, 2014, End date: Aug 31, 2016,

The project addresses critical gaps in our understanding of the role of genome duplication (polyploidy) in the genesis and maintenance of plant diversity. While polyploidization is widely acknowledged as a major speciation mechanism in land plants, little is still known about the performance, dynamics, and evolutionary potential of wild polyploid lineages. In my project I propose an interdisciplin ...
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Probing intracellular folding and dynamics of telomeric DNA structures with single-molecule FRET (G4invivo)

Start date: Jan 1, 2016, End date: Dec 31, 2017,

...es, the ends of linear eukaryotic chromosomes, are one of the most versatile “molecular machines” of life. They perform a vital role in several fundamental processes in biology, as maintenance of genome integrity and the regulation of cell growth. Human telomeric DNA consists of thousands of tandem repeats of guanine-rich sequences, terminating the chromosomes. Under physiological conditions, such ...
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High-throughput dissection of the genetics underlying complex traits (COMPLEX_TRAITS)

Start date: Nov 1, 2012, End date: Oct 31, 2017,

...g approaches that have revealed crucial information about the complexity of the underlying genetics. Here we propose to advance to the next level of complex trait dissection by developing systematic, genome-wide technologies that aim to identify all of the variants underlying a complex trait in a single step. In particular, we will investigate traits involved in mitochondrial function, which are b ...
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Sex differences in expression in the shared genome (SexDiff)

Start date: Mar 1, 2016, End date: Feb 28, 2018,

...ionary causes of sex differences in gene expression remain essentially unknown and pose a fundamental problem for biologists: How do sex differences evolve given that the sexes largely share the same genome?My research addresses this fundamental question using two approaches: (1) a data-driven, large-scale phylogenetic approach, and (2) an experimental manipulation of chromosome dose in Drosophila ...
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Sex-limited experimental evolution of natural and novel sex chromosomes: the role of sex in shaping complex traits (ComplexSex)

Start date: May 1, 2016, End date: Apr 30, 2021,

...sex-linked genetic variation, and sex-specific selection shape the genetic architecture of complex traits. I will test the hypotheses that: 1) individual sexually antagonistic loci are common in the genome, both in separate-sexed species and in hermaphrodites, and drive patterns of sexual antagonism often seen on the trait level. 2) That the response to sex-specific selection in sex-linked loci i ...
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Multi-functional Computational Microscopy for Quantitative Cell Tracking (MCMQCT)

Start date: Aug 1, 2015, End date: Jul 31, 2018,

...ion, quantitative cell tracking. We believe that these functionalities and the platform's cost effectiveness will enable next generation high-throughput scientific research on the influence of drugs, genome modification and environmental changes, developing new models for cell locomotion, such as viral plague growth assays performed in hospitals and clinics, detection of parasites and bacteria in ...
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Uncovering targets for ex vivo expansion of hematopoietic stem cells to enhance cell therapies of blood disorders (UNEXPECTED)

Start date: Aug 1, 2015, End date: Jul 31, 2020,

...ches based on both CRISPR/Cas9 gene editing and RNA interference (RNAi) gene silencing to identify regulators of renewal and differentiation in human HSCs. Large numbers of HSCs will be targeted with genome-wide lentiviral CRISPR (sgRNA) and short hairpin RNA (shRNA) libraries. Screening assays for HSC self-renewal will be evaluated in a pooled format and de-convoluted using next generation sequen ...
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SHARING A GENOME: CASTE ANTAGONISM AND COADAPTATION IN SOCIAL INSECTS (CASTECON)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

Eusociality, in which workers sacrifice their own reproduction to rear the offspring of queens, is a major focus of interest in evolutionary biology. A key aim during recent decades has been to understand the conflicts of interest within eusocial groups. In contrast, however, little is known about the underlying genetic architecture. In this proposal, we will use a mixture of field experiments and ...
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COmplete Nucleic acid ANalysis at genome scale using ultra high throughput sequencing (CONAN)

Start date: Jul 1, 2016, End date: Dec 31, 2016,

The human genome project has not fully delivered the benefits promised in terms of cost and utility. Complete genome sequencing still costs greater than 1,000€ and offers most people limited value (for example in terms of immediate health benefits). New levels of genetic complexity have been uncovered with the discovery of different types of molecular switches that control the activity of the gene ...
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Medical translation in the history of modern genomics (TRANSGENE)

Start date: Oct 1, 2016, End date: Sep 30, 2021,

...w and why this objective of completing the sequence was adopted in preference to other models that prioritised the usability of the data.Newly available archives suggest that the yeast, human and pig genome initiatives underwent crucial changes from the mid-1980s onwards. In their early years, the priority had been rapid translation of results into the improvement of human and animal health. Conse ...
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Labeling Flavivirus capsid protein to unravel its dynamics during infection and egress by correlative super-resolution fluorescence and cryo-electron microscopy (FLAVIC DYNAMICS)

Start date: Sep 1, 2017, End date: Aug 31, 2019,

...avivirus. Significant advances in understanding flavivirus biology can be expected if such labeling tools were available.The major goal of this project is to understand the delivery of the flavivirus genome to its translation site at the cytoplasmic side of the ER membrane; the cellular components and machineries that intervene and the role and paths of the Capsid protein during this process. Supe ...
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Genetic High Throughput Screenings by random mutagenesis to identify Plasmodium falciparum critical genes for asexual growth, sexual differentiation and virulence affecting host immune responses (GeneticHTS reveal Pf)

Start date: Feb 1, 2011, End date: Feb 21, 2018,

...odium life cycle and the interactions with the host, especially with the immune system. Indeed, despite in the past few decades Plasmodium research was notably forwarded by availability of new tools, genome, microarray and proteomic data, basic and important questions on its biology are still shockingly unanswered. The field is still in great demand of approaches that allow discovering the functio ...
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Integrated evolutionary analyses of genetic and drug interaction networks in yeast (network evolution)

Start date: Jul 1, 2008, End date: Jun 30, 2013,

...tems biology with microbial evolutionary experiments. In collaboration with several leading research teams in the field, we plan to investigate the following issues. First, we will ask how accurately genome-scale metabolic network models can predict the impact of genetic deletions and other non-heritable perturbations. Second, to understand how the impact of genetic and drug perturbations can be m ...
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Development of the Cephalochordate amphioxus, Branchiostoma lanceolatum, as a new model for regeneration (AmphiREG)

Start date: Apr 15, 2009, End date: Apr 14, 2011,

... considerations, and are often plagued by duplicated genes, hindering functional analyses. The invertebrate cephalochordate amphioxus is the most basal chordate. It is characterised by a prototypical genome, ancestral chordate morphology, and lacks the whole-genome duplications characteristic of vertebrates. With sequencing of the genome, it is therefore an excellent model for evolution of develop ...
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Biological agents that actively attack Cultural Heritage stoneworks (BIOATTACH)

Start date: Jun 1, 2009, End date: Jul 31, 2011,

...rs” in the biodeterioration processes and on the understanding of their function and activity. The project will use the most advanced techniques in the microbial molecular ecology including Whole Genome Amplification, 16S rRNA gene, functional gene and RNA analyses to investigate the active components of the microbial community colonising outdoor CH stoneworks. The project has a multidisciplinary ...
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Dorsal Horn Interneurons in Sensory Processing (DHISP)

Start date: May 1, 2010, End date: Apr 30, 2016,

... very limited. This proposal aims at a comprehensive characterization of the dorsal horn neuronal network under normal conditions and in chronic pain states with a focus on inhibitory interneurons. A genome-wide analysis of the gene expression profile shall be made from defined dorsal horn interneurons genetically tagged with fluorescent markers and isolated by fluorescence activated cell sorting. ...
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European large-scale functional genomics in the rat for translational research (EURATRANS)

Start date: Apr 1, 2010, End date: Mar 31, 2015,

Genetic studies in model organisms and humans, including human genome-wide association studies, have pinpointed genomic regions that contribute susceptibility to common disease. However, to date, these data have provided limited insights into the genes, molecular pathways and mechanisms underlying disease pathophysiology.The EU FP6 Euratools consortium has been a remarkable success that establishe ...
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A Computational Systems Biology Approach to Reveal the Molecular Basis of Complex Diseases (EYLCompDisSysBio)

Start date: Apr 1, 2010, End date: Mar 31, 2014,

...ases is essential for opening new avenues for treatment. In an effort to elucidate their mechanisms, complex diseases are increasingly studied using state-of-the-art high-throughput assays, including genome-wide association studies (GWAS) and mRNA profiling. However, each assay enables only a limited understanding of disease processes. GWAS typically identify many genomic loci whose relation to th ...
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A Systems Biology Approach to Elucidate the Yeast Metabolic Network (MRM-Yeast Metabolism)

Start date: May 1, 2008, End date: Apr 30, 2010,

...metabolic enzymes will be coupled to quantitative data of the associated mRNA transcripts, metabolites and metabolic fluxes. Integration of these different quantitative data types will be done with a genome-scale mathematical model of the whole yeast metabolism. The data generated will be unprecedented and the research will set us on a path towards the understanding of the control structure of S. ...
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TCF4 transcriptional program in crypt stem cells and resulting differentiated cells (gut gene regulation)

Start date: Mar 1, 2008, End date: Feb 28, 2010,

...um is a rapidly renewing tissue under the control of the canonical Wnt pathway, and therefore ideal to study the above mentioned questions. The proposed project combines state of the art ChIP on chip Genome wide Agilent DNA arrays, Mass Spectrometry, Flow Cytometry, as well as conventional Biochemistry and Molecular Biology to examine Wnt/TCF4 controlled intestinal development in mice. Using these ...
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Design, Synthesis and Biological Evaluation of HIV-1 and HCV inhibitors (AntiViral)

Start date: Sep 3, 2007, End date: Apr 30, 2013,

...ptase activity, is compromised by the persistence of viral reservoirs, drug resistance and adverse side effects. HIV-1 integrase (IN), the enzyme responsible for integrating the viral DNA to the host genome, is essential for viral replication and represents an ideal target for drug design. The current treatment for HCV of interferon-α and ribavirin has demonstrated limited success in treating all ...
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Genome-wide study of human epigenetic regulators (EPIX)

Start date: Sep 1, 2010, End date: Aug 31, 2014,

"Epigenetics is a new frontier in biology. It has yielded revolutionary insight into how the genome works, and has profound implication for human health.This project focuses on the best-established epigenetic mark, DNA methylation. This mark is essential for the embryonic development and adult life of mammals, and acts primarily by regulating gene expression.While the essential functions of DNA me ...
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Next generation disease mapping (NextGene)

Start date: Oct 1, 2010, End date: Dec 31, 2014,

During the last few years, most major disease phenotypes have been studied through genome-wide association mapping. This has been a remarkably successful enterprise, resulting in the discovery of more than 500 validated SNP-phenotype associations. Yet, these associations do not explain all the heritability of many common genetic diseases and it is not at all clear how they exert their effect at th ...
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Exploring the fundamental biology of microsporidian mitosomes (MICMIT)

Start date: May 2, 2011, End date: May 1, 2013,

...ATP. Mitosomes are vital for parasite survival because they contain key components of the essential pathway for mitochondrial iron-sulphur cluster biosynthesis. However, from published and in- house genome data it appears that the transport proteins that support mitochondrial Fe-S protein biogenesis in model organisms, have been lost by the parasites. These data raise fundamental questions of ho ...
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Genetic studies of pre-eclampsia in Central Asian and European populations (INTERPREGGEN)

Start date: Nov 1, 2011, End date: Oct 31, 2016,

...on, and through training of Central Asian researchers in centres of excellence in Europe. We shall address the limited knowledge of genetic diversity in Central Asian populations by undertaking whole genome sequencing, analogous to the 1000 Genomes project. We will establish the first pre-eclampsia biobanks of DNA and plasma samples from a total of 4000 affected women, their partners and babies, a ...
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Uncovering the Mechanisms of Cardiomyocyte Differentiation and Dedifferentiation (CM TURNOVER)

Start date: Jan 1, 2012, End date: Dec 31, 2016,

...apacity of adult CMs to renew themselves under normal and pathological conditions, in Aim 3, we will employ a novel cell lineage methodology in mouse and human tissue, based on information encoded in genome. Using this methodology, we hope to shed light on the maintenance, renewal and regenerative capacities of adult CMs in vivo. The expected outcome will be a significantly greater understanding o ...
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Assessing the effect of early social environment on epigenetic modification (SEEM)

Start date: Sep 1, 2011, End date: Aug 30, 2016,

... epigenetic changes leading to psychiatric disorders has been limited to date, because epigenetic modifications are tissue-specific, and only postmortem studies could use brain tissues. However, with genome-wide analyses it became possible to discover similarities of epigenetic changes in different tissues. DNA methylation pattern of certain gene regions could be concordant in the brain and access ...
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Diagnostic and prognostic biomarkers for inflammatory bowel disease IBD-BIOM (IBD-BIOM)

Start date: Oct 1, 2012, End date: Sep 30, 2016,

...ses that need. IBD-BIOM is a multidisciplinary consortium of leading academic and industrial SME researchers in inflammatory bowel disease, genomics, glycomics, glycoproteomics and activomics. Recent genome-wide association studies performed by IBD-BIOM partners have identified nearly 100 genes associated with IBD, but clinical application of these is so far limited. IBD-BIOM will capitalise on it ...
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Development of Effective Vaccines against Multiple Lifecycle Stages of Plasmodium vivax malaria (MultiViVax)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

Plasmodium vivax is the most widespread malaria and constitutes a significant proportion of human malaria cases. P. vivax accounts for 100-400 million clinical cases each year among the 2.5 billion people living at risk in Latin America, Oceania and Asia. The recently revised Malaria Vaccine Technology Roadmap to 2030 recognises the severity of P. vivax malaria and calls for a vaccine intervention ...
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Optimizing a deployable high efficacy malaria vaccine (OptiMalVax)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

A highly effective malaria vaccine against Plasmodium falciparum should help prevent half a million deaths from malaria each year. New vaccine technologies and antigen discovery approaches now make accelerated design and development of a highly effective multi-antigen multi-stage subunit vaccine feasible. Leading malariologists, vaccine researchers and product developers will here collaborate in ...
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A multicenter phase IIb study using HLA-unmatched allogeneic placenta-derived stromal cells (PLX-PAD) for the treatment of severe critical limb ischemia accompanied by mechanistic studies (PACE)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

PACE aims to transform the treatment of patients suffering from critical limb ischemia (CLI), a disease with high medical need, because of limited treatment options and poor outcome by applying a novel, off-the-shelf allogeneic placenta-derived stromal cell product (PLX-PAD). Despite improvements in medical care and revascularization, patients with CLI continue to have a high risk of major amputat ...
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Towards enduring mouse resources and services advancing research into human health and disease (INFRAFRONTIER2020)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

The INFRAFRONTIER RI integrates European Mouse Clinics and the European Mouse Mutant Archive with the common goal to ensure access to mouse models for basic research of human health and disease, and to translate this knowledge into therapeutic approaches for the benefit of the European society. The expanded INFRAFRONTIER2020 network, coordinated by the INFRAFRONTIER GmbH, includes 3 SMEs and is st ...
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New players in human BAT differentiation and activation: a human PSC-derived BAT approach combined with state of the art genome engineering and –omics based methodologies (StemBAT)

Start date: Jan 1, 2016, End date: Dec 31, 2020,

...utic relevance that promote BAT development and/or activation/recruitment using a stem cell based BAT differentiation approach, and then to functionally validate the role of these factors in vitro by genome engineering human stem cell derived adipocytes and in vivo by transplanting these cells into mice. Specific Aims are: 1.To identify molecular mechanisms involved in human brown adipose tissue d ...
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