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Role of sphingolipids in white matter dysfunction in Huntington's disease (HDLIPIDS2011)
Start date: Jun 10, 2013, End date: Jun 9, 2015,
Huntington’s disease (HD) is a neurodegenerative disorder caused by expansion of a CAG repeat, within the gene encoding huntingtin (Htt) and characterized by the progressive neurodegeneration and associated motor, cognitive and behavioral disturbances. Mutant Htt exerts adverse effects in neurons and non-neuronal cells. Animal studies describe white matter segmentation and myelin breakdown in HD. ...
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