Search for European Projects

Over 40 European Projects Found

Searched on 125080 European Projects

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SPIDIA for Personalized Medicine - Standardisation of generic Pre-analytical procedures for In-vitro DIAgnostics for Personalized Medicine (SPIDIA4P)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

Molecular in vitro diagnostics and biomedical research have allowed great progress in personalised medicine but further progress is limited by insufficient guidelines for pre-analytical workflow steps (sample collection, preservation, storage, transport, processing etc.) as well as by insufficient quality assurance of diagnostic practice. This allows using compromised patients’ samples with post c ...
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 21

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circular RNA Biology Training Network: from biogenesis to biomarkers (circRTrain)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

CircRTrain focuses on circular RNAs (circRNAs), a new large class of single-stranded RNAs with covalently closed ends. CircRNAs have only very recently attracted high general interest and become the focus of an increasing number of publications: recent discoveries through sequencing technology and computational analyses have revealed the widespread existence of circRNAs in animal cells. Particular ...
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 8

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Engineering of a minimal bacterial therapeutic chassis (MYCOCHASSIS)

Start date: Nov 1, 2015, End date: Oct 31, 2020,

Engineering bacteria to deliver therapeutic agents or to present antigens for vaccination is an emerging area of research with great clinical potential. The most challenging issue in this field is the selection of the right bacteria to engineer, commonly known as “chassis”. The best chassis depends on the application but there is a common drawback in bacteria used nowadays: their complexity and th ...
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Mechanisms of alternative pre-mRNA splicing regulation in cancer and pluripotent cells (MASCP)

Start date: Oct 1, 2015, End date: Sep 30, 2020,

Alternative splicing of messenger RNA precursors is a prevalent form of gene regulation that greatly expands the coding capacity and regulatory opportunities of higher eukaryotic genomes. It contributes to cell differentiation and pluripotency and its deregulation promotes cancer progression, as evidenced by the frequent occurrence of cancer-associated mutations in splicing factors, which are also ...
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A data-driven multiscale simulation of organogenesis (SIMBIONT)

Start date: Sep 1, 2015, End date: Aug 31, 2020,

Organogensis is the process by which multiple different cell types grow, differentiate and interact with each other (both molecularly and physically) to create large complex structures with integrated functions, such as the heart, brain or limb. Understanding this process has enormous potential impact, both scientifically and medically. The SIMBIONT project represents both a grand technical challe ...
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Breast CAncer STratification: understanding the determinants of risk and prognosis of molecular subtypes (B-CAST)

Start date: Sep 1, 2015, End date: Aug 31, 2020,

Breast tumours are heterogeneous, and result from the complex interplay of multiple lifestyle/environmental and genetic risk factors. Through the EU-funded COGS project, we have identified a large number of germline variants that influence the risk of breast cancer. In combination, these variants can identify women at wide ranges of genetic risk, even in the absence of family history of breast can ...
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 13

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Engineering of Mycoplasma pneumoniae as a broad-spectrum animal vaccine (MycoSynVac)

Start date: Apr 1, 2015, End date: Mar 31, 2020,

Mycoplasmas are the smallest cell wall less, free-living microorganisms. The lack of a cell wall makes them resistant to many of the common antibiotics. Every year, infections caused by Mycoplasmas in poultry, cows, and pigs, result in multimillion euros losses in USA and Europe. Currently, there are vaccines against M hyopneumoniae in pigs and M gallisepticum and M synoviae in poultry. However, t ...
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 9

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A multidisciplinary approach to cell division: From human oocyte to synthetic biology (DivIDe)

Start date: Apr 1, 2016, End date: Mar 31, 2020,

The cell is the universal unit of living matter, and there cannot be propagation of life without cell division. DivIDe aims to investigate the mechanisms and principles of cell division and to reproduce them in vitro with synthetic approaches. Crucial to cell division is the mitotic spindle, a structure whose main duty is the separation of chromosomes. The spindle is made of microtubules (MT), mol ...
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 9

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Functions and evolutionary impact of transcriptomic novelties in the vertebrate brain (NEURAL AS)

Start date: Apr 1, 2015, End date: Mar 31, 2020,

Alternative splicing (AS) is the largest contributor to transcriptomic diversification in metazoans. In particular, mirroring their unparalleled morphological and cellular complexity, vertebrate brains show the highest levels of regulated AS known in nature. However, the functions of most of these alternative transcripts, and the evolutionary impact that the increased transcriptional complexity ha ...
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CellViewer: super-resolution systems microscopy to assess pluripotency and differentiation of stem cells at single cell level (CellViewer)

Start date: Feb 1, 2016, End date: Jan 31, 2020,

In this ambitious and multi-disciplinary proposal, we aim to develop new technologies that will allow us to visualize in single cells, in parallel and at the systems level, DNA, mRNAs and proteins with nanoscale resolution. We will refer to these novel technologies as the ‘CellViewer’: a unique cutting-edge high-throughput super-resolution (SR) microscopy approach (including new hardware and softw ...
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 6

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Promoting SINgle cell GEnomics to explore the ecology and evolution of hidden microeuKaryotes (SINGEK)

Start date: Jan 1, 2016, End date: Dec 31, 2019,

Environmental microbial surveys have revealed a remarkable diversity of microeukaryotic life in most ecosystems, the majority of which had previously escaped detection. From an ecological point of view this work highlighted our ignorance of critical microbial players in natural environmental processes, including primary production, biogeochemical cycling and trophic interactions such as parasitism ...
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 9

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OpenRiskNet: Open e-Infrastructure to Support Data Sharing, Knowledge Integration and in silico Analysis and Modelling in Risk Assessment (OpenRiskNet)

Start date: Dec 1, 2016, End date: Nov 30, 2019,

Toxicology and risk assessment are undergoing a paradigm shift, from a phenomenological to a mechanistic discipline based on in vitro and in silico approaches that represent an important alternative to classical animal testing applied to the evaluation of chronic and systemic toxicity risks. Large databases and highly sophisticated methods, algorithms and tools are available for different tasks su ...
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 14

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Phylogeography and somatic evolution of cancer tumor cells (PHYLOCANCER)

Start date: Oct 1, 2014, End date: Sep 30, 2019,

"By far, most evolutionary research has focused on the changes that occur in the germline of individuals across generations, within and between species. For different reasons, much less attention has been given to the process of change within the somatic line of a multicellular individual. The formation of cancer tumors due to uncontrolled cell proliferation is one of the most prominent forms of s ...
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 4

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Neuronal Alternative Splicing and RNA-Editing Crosstalk (NeuroASPECT)

Start date: Sep 1, 2017, End date: Aug 31, 2019,

A long-standing question in biology has been to determine how the mammalian central nervous system (CNS) achieves its dramatic cellular complexity and connectivity. Notably, mechanisms increasing transcript diversity, particularly alternative splicing (AS) and RNA-editing, have critical roles in the mammalian CNS development and function. However, it is still unclear whether the crosstalk between ...
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ELIXIR-EXCELERATE: Fast-track ELIXIR implementation and drive early user exploitation across the life-sciences. (ELIXIR-EXCELERATE)

Start date: Sep 1, 2015, End date: Aug 31, 2019,

The life sciences are undergoing a transformation. Modern experimental tools study the molecules, reactions, and organisation of life in unprecedented detail. The precipitous drop in costs for high-throughput biology has enabled European research laboratories to produce an ever-increasing amount of data. Life scientists are rapidly generating the most complex and heterogeneous datasets that scienc ...
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 47

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From Omics to Patient: Improving Diagnostics of Pathogenic Yeasts (OPATHY)

Start date: Sep 1, 2015, End date: Aug 31, 2019,

OPATHY is an innovative translational research training network that will explore the potential of omics technologies, including genomics, transcriptomics and proteomics, to study the interactions of yeasts that cause disease to humans (e.g. Candida and Cryptococcus sp.) with their host, and to develop new diagnostic tools to monitor yeast infections in the clinic. Today, these infections are poor ...
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 10

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Coordinated Research Infrastructures Building Enduring Life-science services (CORBEL)

Start date: Sep 1, 2015, End date: Aug 31, 2019,

The social and economic challenges of ageing populations and chronic disease can only be met by translation of biomedical discoveries to new, innovative and cost effective treatments. The ESFRI Biological and Medical Research Infrastructures (BMS RI) underpin every step in this process; effectively joining scientific capabilities and shared services will transform the understanding of biological m ...
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 39

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Dynamics of human genome architecture in stable and transient gene expression changes (4D-GENOME)

Start date: Jun 1, 2014, End date: May 31, 2019,

The classical view of genomes as linear sequences has been replaced by a vision of nuclear organization that is both dynamic and complex, with chromosomes and genes non-randomly positioned in the nucleus. Process compartmentalization and spatial location of genes modulate the transcriptional output of the genomes. However, how the interplay between genome structure and gene regulation is establish ...
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 2

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Individual Robustness in Development and Cancer (IR-DC)

Start date: Jun 1, 2014, End date: May 31, 2019,

Biological systems are robust to perturbations, with many genetic, stochastic and environmental challenges having no or little phenotypic consequence. However, the extent of this robustness varies across individuals, for example the same mutation or treatment may only affect a subset of individuals. The overall objective of this project is to understand the cellular and molecular mechanisms that ...
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Exploring the combined role of genetic and non-genetic factors for developing Age-Related Macular Degeneration: A systems level analysis of disease subgroups, risk factors, and pathways (EYE-RISK)

Start date: May 1, 2015, End date: Apr 30, 2019,

Age-related macular degeneration (AMD) is the world’s most important age-related blinding disorder. The current proposal utilises epidemiological data describing clinical phenotype, molecular genetics, lifestyle, nutrition, and in-depth retinal imaging derived from existing longitudinal European epidemiological cohorts and biobanks to provide three major insights needed for long-lasting prevention ...
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 13

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Leading Innovative measures to reach gender Balance in Research Activities (LIBRA)

Start date: Oct 1, 2015, End date: Mar 31, 2019,

The main goals of LIBRA are to implement innovative Gender Equality Plans (GEPs) that will empower women researchers to achieve successful careers in science, remove gender barriers and biases at an institutional level, and raise awareness of gender aspects in the experimental design of pre-clinical research projects. To achieve these goals we will: 1) conduct an initial external assessment of eac ...
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 11

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CRG International Postdoctoral Fellowship Programme in Life Sciences (ImPuLSe)

Start date: Jan 1, 2014, End date: Dec 31, 2018,

The proposed “CRG International Postdoctoral Fellowship Programme in Life Sciences” (ImPuLSe) builds on the existing Fellowship Programme “International Interdisciplinary Postdoctoral Programme (InterPod) running from 2010 to 2014, co-funded by the FP7 COFUND scheme. ImPuLSe aims at enabling outstanding junior scientists of all nationalities to develop a competitive research project in life scienc ...
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 1

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Systematic investigation of epistasis in molecular evolution (EinME)

Start date: Jan 1, 2014, End date: Dec 31, 2018,

Why does a mutation have a deleterious effect when it occurs in one species but shows no apparent consequences on the phenotype when it occurs in another species? What are some of possible explanations on the molecular basis of this phenomenon? Are the computational predictions of the extent of this phenomenon in nature accurate? The present project aims to take a swing at answering, at least part ...
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 1

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RD-CONNECT: An integrated platform connecting registries, biobanks and clinical bioinformatics for rare disease research (RD-CONNECT)

Start date: Nov 1, 2012, End date: Oct 31, 2018,

Despite examples of excellent practice, rare disease (RD) research is still mainly fragmented by data and disease types. Individual efforts have little interoperability and almost no systematic connection between detailed clinical and genetic information, biomaterial availability or research/trial datasets. By developing robust mechanisms and standards for linking and exploiting these data, RD-Con ...
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Multi-Scale Complex Genomics (MuG)

Start date: Nov 1, 2015, End date: Oct 31, 2018,

Genomics is probably the fastest evolving field in current science. A decade ago our main concern was to obtain the sequence (the 1D code) of the genome; but today the big challenges are to determine how genotype information is transferred into phenotype, and how pathological phenotypic changes can be predicted from genome alterations. While investigating these points, we have realized that a part ...
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 7

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Personalized bioinformatics for global cancer susceptibility identification and clinical management (PanCanRisk)

Start date: Jul 1, 2015, End date: Jun 30, 2018,

Cancer sequencing studies have extensively investigated the landscape of somatic mutations that drive tumor development, however the importance of germline variation for cancer susceptibility has been neglected. We hypothesize that for cancer types affecting a large proportion of the population, a shared set of genes with variants of different levels of penetrance leads to the clinical phenotype. ...
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 6

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European Consortium for Communicating Stem Cell Research (EuroStemCell)

Start date: Jan 1, 2015, End date: Mar 31, 2018,

The European Consortium for Communicating Stem Cell Research (EuroStemCell) unites 33 partner institutions, that collectively represent >400 stem cell research groupings across Europe. Our common goal is to provide trusted high quality information on stem cells accessible to citizens and stakeholders across Europe, through support and further development of the multi-lingual European Stem Cell Inf ...
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 32

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Detection of Chromatin Bridges during Cytokinesis (NoCut)

Start date: Mar 1, 2016, End date: Feb 28, 2018,

Duplication of the genome and its division into two daughter cells during mitosis is vital for survival of the organism. Cells have multiple mechanisms to ensure that this process is accomplished correctly thereby preserving the integrity of the genome. The final check before cell division is made by the NoCut abscission pathway. In yeast and animal cells, this mechanism monitors completion of ch ...
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 1

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Biogenesis of lipid droplets and lipid homeostasis (DROPFAT)

Start date: Feb 1, 2013, End date: Jan 31, 2018,

Organisms and cells face a myriad of environmental changes with periods of nutrient surplus and shortage. It is therefore not surprising that in all kingdoms of life, cells have evolved the means to store energy and thereby minimize the effects of environmental fluctuations. While the capability for energy storage has obvious advantages, deregulated energy accumulation can also be detrimental and ...
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 2

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Spatiotemporal regulation of epidermal stem cells by circadian rhythms: impact on homeostasis and aging (STEMCLOCK)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

"Most adult stem cells are compartmentalized in functionally deterministic niches where they self-renew and maintain homeostasis. From there, stem cells are instructed by combinations of signals and spatial tensile forces which they translate into a specific behavior. However how stem cells spatiotemporally coordinate their stem cell potential with niche- and systemic cues is poorly understood. Th ...
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 3

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The Role of Non-coding RNA in Protein Networks and Neurodegenerative Diseases (RIBOMYLOME)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

"A major portion of the eukaryotic genome is occupied by DNA sequences whose transcripts do not code for proteins. This part of the genome is transcribed in a developmentally regulated manner and in response to external stimuli to produce large numbers of long non-coding RNAs (lncRNAs). From the beginning of transcription through splicing and translation, RNA molecules are associated with numerous ...
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 1

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Euro-BioImaging Preparatory Phase II - Project (EuBI PPII)

Start date: Jan 1, 2016, End date: Dec 31, 2017,

Euro-BioImaging (EuBI) is the pan-European research infrastructure project for imaging technologies in biological and medical sciences and has been on the ESFRI Roadmap since 2008. In close match with the scope and objectives of the INFRADEV2 call, Preparatory Phase II (PPII) funding will enable EuBI:• to finalize the submission and approval procedure of its ERIC statutes with the EC and bring the ...
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Uncovering and understanding RNA through Massively Parallel Sequencing (RNA-MAPS)

Start date: Apr 1, 2012, End date: Dec 31, 2017,

The overarching goal of the proposal presented here is the use of massively parallel sequencing for the identification of novel genetic and epigenetic factors playing role in RNA processing. Specifically, we plan to focus on the role of long non-coding RNAs and histone modifications in splicing regulation during cell differentiation. Towards that end, we plan to monitor RNA and chromatin changes a ...
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 1

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Synthetic Cellular Signaling Circuits (SynSignal)

Start date: Nov 1, 2013, End date: Oct 31, 2017,

Cellular signaling systems are crucially important for a broad range of critical health and disease areas and high value industrial applications. Signaling systems are the target for more than half of the medicines marketed by the pharmaceutical industry, and form the main R&D area for the nutrition, flavour and fragrance industries. SynSignal is a multidisciplinary high-tech consortium working in ...
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 10

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Molecular Mechanisms of Fungal Pathogen Host Interactions (ImResFun)

Start date: Oct 1, 2013, End date: Sep 30, 2017,

ImResFun shall provide state-of-the-art training in infectious disease research and medical immunology targeting the most common human fungal pathogens, the opportunistic Candida species. The key objectives of ImResFun are: (i) to understand how immune cells and infected organs respond to invasion by Candida spp, (ii) to decipher host-defense mechanisms mediating pathogen elimination, and (iii) to ...
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 12

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The Human Early-Life Exposome – novel tools for integrating early-life environmental exposures and child health across Europe (HELIX)

Start date: Jan 1, 2013, End date: Jun 30, 2017,

The aim of HELIX is to exploit novel tools and methods (remote sensing/GIS-based spatial methods, omics-based approaches, biomarkers of exposure, exposure devices and models, statistical tools for combined exposures, novel study designs, and burden of disease methodologies), to characterise early-life exposure to a wide range of environmental hazards, and integrate and link these with data on majo ...
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 16

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Interconnection between R-loops and co-transcriptional alternative splicing (RLOOP-AS)

Start date: Jul 1, 2015, End date: Jun 30, 2017,

R-loops are long RNA/DNA hybrids naturally formed behind RNA polymerase II (Pol II) during transcription, but their persistence is a threat for genome integrity through the creation of DNA damage, leading to cancer development. However, several recent studies reported a new and exciting role for R-loops in gene expression regulation by influencing transcription termination and chromatin modificati ...
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Regulation of early embryo development and pluripotency through alternative splicing (EDPAS)

Start date: Jul 1, 2015, End date: Jun 30, 2017,

Understanding how the differentiation potential of the mammalian embryo gets restricted during development is a key question in the embryology and stem cell fields. Alternative splicing (AS) is the process by which different exons are selected in precursor mRNAs to generate multiple protein products. Recent studies have shown that 95% of human multiexonic genes undergo AS, however little is known ...
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Mechanisms of kinesin-dependent RNA transport and translational regulation (RNA Transport and Control)

Start date: Jun 1, 2015, End date: May 31, 2017,

Active mRNA transport and localisation are crucial for spatiotemporal control of gene expression. In neurons, dendritic mRNA transport and local translational control are required for synaptic plasticity and memory formation. Misregulation has been linked to severe diseases. RNA-binding proteins (RBPs), kinesin motor proteins, mRNAs and noncoding RNAs (ncRNAs) are involved in dendritic mRNA transp ...
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Chromosome Segregation and Aneuploidy (LONGCHROM)

Start date: Jun 1, 2011, End date: May 31, 2017,

Accurate partitioning of the genetic material during cell division is critical for genetic stability. Defects in chromosome segregation produce aneuploidy, an unequal distribution of chromosomes between daughter cells, which is cause of developmental defects, and one of the cancer hallmarks. To ensure error-free transmission of chromosomes, feedback control systems verify that processes at each st ...
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