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Towards Understanding the mechanism of positive supercoiling by reverse gyrase from Thermotoga maritima (Rev Gyr Mech)
Start date: Jun 12, 2009, End date: Jun 11, 2011,
Reverse gyrase is the only topoisomerase known till date that can introduce positive supercoils into DNA. From the biochemical and biophysical evidence gained so far, it is known that the enzyme only relaxes negatively supercoiled DNA, and introduces positive supercoils in presence of ATP at high temperatures. The exact picture of conformational changes and inter-domain cross talk during the posit ...
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