20 European Projects Found
Searched on 125080 European Projects
FINISHED
Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)
Start date: Jan 1, 2015, End date: Dec 31, 2021,
Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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44
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REgenerative Stem cell therapy for STroke in Europe (RESSTORE)
Start date: Sep 1, 2015, End date: Aug 31, 2020,
...g preclinical and pilot clinical evidences, RESSTORE will focus on the clinical assessment of regenerative cell therapy to improve stroke recovery and patients quality of life. RESSTORE European multicentre randomised phase IIb will explore, for the first time, the efficacy (functional recovery) and safety of intravenous infusion of allogenic adipose tissue derived mesenchymal stem cells (ADMSCs) ...
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29
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European Prevention of Alzheimer’s Dementia Consortium (EPAD)
Start date: Jan 1, 2015, End date: Dec 31, 2019,
Background:The secondary prevention of Alzheimer’s dementia (AD) is achievable if we can identify individuals at risk of disease progression defined by biomarker evidence of AD pathology and no or only minimal clinical symptoms and engage them in a standing adaptive clinical trial, of the highest quality, testing multiple interventions. To achieve this, EPAD will also provide the analytical infras ...
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40
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Clinical trial of autologous adipose-derived mesenchymal stromal cells (ASC) in the treatment of mild to moderate osteoarthritis (ADIPOA2)
Start date: Jan 1, 2015, End date: Dec 31, 2018,
...(ASCs) are attractive for cellular therapy given the abundance of tissue, high frequency of MSCs and minimally invasive harvest procedure. The EU consortium ADIPOA has shown in a ‘first in man’ 2-centre Phase I safety study that intraarticular injection of a single dose of autologous ASCs to the knee (18 patients, 12 month follow-up) was well-tolerated, had no adverse effects, and resulted in an i ...
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20
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TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development (TBVAC2020)
Start date: Jan 1, 2015, End date: Dec 31, 2018,
The TBVAC2020 proposal builds on the highly successful and long-standing collaborations in subsequent EC-FP5-, FP6- and FP7-funded TB vaccine and biomarker projects, but also brings in a large number of new key partners from excellent laboratories from Europe, USA, Asia, Africa and Australia, many of which are global leaders in the TB field. This was initiated by launching an open call for Express ...
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49
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Metagenomics in Cardiometabolic Diseases (METACARDIS)
Start date: Nov 1, 2012, End date: Oct 31, 2018,
.... The pathophysiological role of these markers will be tested in both preclinical models and replication cohorts allowing the study of CMD progression in patients collected in three European clinical centres of excellence. Their impact on host gene transcription will be characterised in patients selected for typical features of CMD evolution. Application of computational models and visualisation t ...
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18
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Biomarkers of renal graft injuries in kidney allograft recipients (BIOMARGIN)
Start date: Mar 1, 2013, End date: Feb 28, 2018,
In renal allograft recipients, 10-year graft survival has not improved over the past decades. Histological examination of graft biopsies has long been the gold standard to confirm graft injuries, but biopsies are invasive and histological grading is not very robust. There is thus a need for robust, non-invasive methods to predict and diagnose acute and chronic graft lesions, to improve patient tre ...
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13
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Open Project for the European Radiation Research Area (OPERRA)
Start date: Jun 1, 2013, End date: May 31, 2017,
"Within the OPERRA project, it is proposed that the MELODI Association, as a well-advanced network, takes the lead in establishing the necessary structures able to manage the long-term European research programmes in radiation protection, also taking advantage of the valuable experience gathered through the DoReMi network of excellence. Whilst in fields adjacent to low-dose risk research (radioeco ...
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71
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Anti-Biopharmaceutical Immunization:Prediction and analysis of clinical relevance to minimize the risk (ABIRISK)
Start date: Mar 1, 2012, End date: Feb 28, 2017,
The ABIRISK project provides an integrated approach to the study of immunization against biopharmaceuticals, bringing together a unique panel of experts from different disciplines. ABIRISK will involve many of the European leaders in rheumatology, gastroenterology, hemophilia and multiple sclerosis, caring for ~30,000 patients treated with biopharmaceuticals, with ~10,000 additional patients recru ...
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39
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Treat Infections in NeoNates 2 - Evaluation of an infective agent (azithromycin) for the treatment of infections in preterm and term neonates (TINN2)
Start date: Jan 1, 2011, End date: Dec 31, 2015,
"The aim of TINN2 is to evaluate azithromycin, included in the EMEA priority list of the therapeutic areas that need specific drug evaluation in preterm and term neonates. Azithromycin is a macrolid antibiotic with anti-inflammatory properties active against Ureaplasma. It might be effective in reducing the severity of bronhopulmonary disease in which Ureaplasma infection and inflammation play a r ...
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17
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Evaluation of antibiotics (ciprofloxacin and fluconazole) for the treatment of infections in preterm and term neonates (TINN)
Start date: Nov 1, 2008, End date: Oct 31, 2015,
The aim of TINN is to evaluate ciprofloxacin, fluconazole and micafungin in neonates; two anti-infectious drugs included in the EMEA priority list of the therapeutic areas that need specific drug evaluation in preterm and term neonates. These drugs are prescribed off-label to treat neonatal infections that are life threatening situations and associated with long-term complications. In order to val ...
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16
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Regenerating Bone defects using New biomedical Engineering approaches (REBORNE)
Start date: Jan 1, 2010, End date: Jun 30, 2015,
...m clinical trials using advanced biomaterials and cells triggering bone healing in patients. In order to reach this goal, five phase II clinical studies with 20 patients are proposed in 12 clinical centres spread in 8 European countries. Three orthopaedic trials concerning the treatment of long bone fractures and osteonecrosis of the femoral head in adults or children will be conducted using bioce ...
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24
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Riskmanche
Start date: Aug 31, 2011, End date: Jun 29, 2015,
Riskmanche is a scientific research project with the stategic aim of reducing risks to human health that are linked to water and to shellfish.
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7
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Suicidality: Treatment Occurring in Paediatrics (STOP)
Start date: Nov 1, 2010, End date: Apr 30, 2015,
The emergence of suicidality in patients receiving drug treatment is of concern because of the overall burden and the possible link with completed suicide. The lack of uniform requirements for defining, detecting and recording suicidality and the presence of disease related confounders create major problems. It is possible that Medication-Related Suicidality (MRS) differs from Psychopathology-Rela ...
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19
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EU and North African Migrants: Health and Health Systems (EUNAM)
Start date: Apr 1, 2011, End date: Mar 31, 2015,
The coordinates of human health are complex even in a single population but they are even more complex in migrants whose life situation is always influenced by the host country and the country of origin. Some migrants may experience several host countries and some return to the country of origin. Thus it is important to survey well being, health status, disease panorama and use of health services ...
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8
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EUROPEAN PHYTOSANITARY RESEARCH COORDINATION II (EUPHRESCO)
Start date: Jan 1, 2011, End date: Mar 31, 2014,
The Community Plant Health Regime (CPHR) aims to prevent the introduction, establishment and spread of regulated and quarantine plant pests. These pests pose increasing risks to European agriculture, horticulture, forestry and the environment. This is due to increased globalisation of trade (volume and diversity), but is exacerbated by climate change and EU expansion (increased pathways). In compa ...
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37
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Discovery and preclinical development of new generation tuberculosis vaccines (NEWTBVAC)
Start date: Jan 1, 2010, End date: Feb 28, 2014,
"With 14.4 million prevalent cases and 1.7 million deaths tuberculosis (TB) remains one of the most serious infectious diseases to date. An estimated 2 billion people are believed to be infected with Mycobacterium tuberculosis and at risk of developing disease. Multi- and extensively drug resistant strains are increasingly appearing in many parts of the world, including Europe. While with current ...
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39
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Treatment of reperfusion injury using a mitochondrial targeted approach: towards a better understanding of the disease (MITOCARE)
Start date: Jan 1, 2011, End date: Dec 31, 2013,
"Current interventional treatment of acute myocardial infarction (AMI) focused on re-establishing cardiac reperfusion has significantly improved clinical outcome by reducing infarct size and mortality due to cardiac ischemia.It is now recognized that events triggered at reperfusion also result in cell death and may account for as much as 50% of the infarct volume, this being termed ischemia-reperf ...
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18
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THERAPEUTISCHE UND PRÄVENTIVE BILDUNGSMASSNAHMEN BEI DIABETES UND RISIKO-FETTSUCHT BEI ERWACHSENEN UND JUGENDLICHEN (EDUDORA 2)
Start date: May 31, 2009, End date: Jan 30, 2013,
Ziel dieses Projekts ist die Einrichtung eines grenzüberschreitenden Netzes (Wallonien - Großherzog-tum Luxemburg - Lothringen) zur Verbesserung der Aus- und Weiterbildung des Pflegepersonals. Das Projekt konzentriert sich auf eine multidisziplinäre Schulung des Patienten und die Prävention bei Personen, die unter Diabetes oder Fettsucht mit hohem Diabetesrisiko leiden. Unter Berücksichtigung der ...
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8
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Le projet comporte trois phases opérationnelles: 1. Validation, harmonisation et standardisation des données existantes relatives aux risques cardiovasculaires; 2. Etude de mise en place d'une cohorte pilote: recherche des facteurs génétiques et environnementaux associés aux risques cardiovasculaires; 3. Pré-cahier des charges d'un cardiopôle - prévention transfrontalier.
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