7 European Projects Found
Searched on 125080 European Projects
FINISHED
Immune Functions of Myeloid Syk-coupled C-type Lectin Receptors Sensing Necrosis (CLR Sensing Necrosis)
Start date: Dec 1, 2010, End date: Aug 31, 2016,
...ells can trigger adaptive immunity in infection-free situations, such as autoimmunity or therapy-induced tumour rejection. Recently, we and others have identified the myeloid C-type lectin receptors (CLRs) CLEC9A (DNGR-1), in DC, and Mincle, in macrophages, as receptors for necrotic cells that can signal via the Syk kinase. Previous studies on similar Syk-coupled CLRs showed that Dectin-1 and Dect ...
Read Project
1
Partner Participant
FINISHED
Neurotransmitter Cys-loop receptors: structure, function and disease (NeuroCypres)
Start date: Feb 1, 2008, End date: Jul 31, 2012,
Cys-loop receptors (CLRs) form a superfamily of structurally related neurotransmitter-gated ion channels, comprising nicotinic acetylcholine, glycine, GABA-A/C and serotonin (5HT3) receptors, crucial to function of the peripheral and central nervous system. CLRs cover a wide spectrum of functions, ranging from muscle contraction to cognitive functions. CLR (mal)function is linked to various disord ...
Read Project
24
Partners Participants
FINISHED
Discovery of novel cancer serum biomarkers based on aberrant post translational modifications of O-glycoproteins (O-PTM-Biomarkers) and their application to early detection of cancer (O-PTM-Biomarkers)
Start date: Jan 1, 2008, End date: Mar 31, 2011,
Early detection accomplished through an efficient screening programme remains the most promising approach to improve the long-term survival of cancer patients. Therefore there is a pressing need for the development of biomarkers, which detect the early changes for cancers where clinical symptoms only appear when the cancer has progressed, and treatment is ineffective. Our proposal, which addresses ...
Read Project
9
Partners Participants
FINISHED
The dendritic cell receptor DNGR-1: Modulation of endosomal dynamics upon recognition of necrotic cells (DNGR-1 in DCs)
Start date: May 1, 2013, End date: Apr 30, 2015,
...zing and capturing pathogens and damaged cells and for controlling subsequent antigen extraction, processing and presentation. DNGR-1 (also known as CLEC9A) is a DC-restricted C-type lectin receptor (CLR) that recognizes the actin cytoskeleton exposed on necrotic cells. DNGR-1 is not required for internalization of cell corpses by DCs but regulates their subsequent ability to crosspresent corpse-a ...
Read Project
2
Partners Participants
FINISHED
A Multiscale Simulation-Based Design Platform for Cost-Effective CO2 Capture Processes using Nano-Structured Materials (NanoSim) (NanoSim)
Start date: Jan 1, 2014, End date: Dec 31, 2017,
...orm will be used to facilitate the rational design of second generation gas-particle CO2 capture technologies based on nano-structured materials with a particular focus on Chemical Looping Reforming (CLR). However, the final NanoSim platform will be sufficiently generic for application in a wide range of gas-particle contacting processes.Finally, the NanoSim project will demonstrate the capabiliti ...
Read Project
8
Partners Participants
FINISHED
... for accreditation of prior learning), Liftgroup (Learning Innovation Fashion Textile, knowledge centre for the textile, carpet, fashion and retail industry), Hogeschool Arnhem en Nijmegen (HAN), and CLR (involved in the innovation and coordination of competence development). Early 2008 they joined forces with organizations and experts in other European countries (United Kingdom, Belgium, Greece, ...
Read Project
12
Partners Participants
FINISHED
The labour market is affected by economic changes and influences. This has tremendous influence on the professional paths of European workers. The most vulnerable go in and out of employment in short cycles during their professional lives. Individuals have to manage these professional transitions and face uncertainties all along their careers. In this context, the specific characteristics of women ...
Read Project
