Search for European Projects

24 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Understanding and exploiting complex glycan metabolism in the human microbiota (Human microbiota)

Start date: May 1, 2013, End date: Apr 30, 2018,

The human large bowel is colonized by a community of microbes, the microbiota, which has a significant impact on human health and nutrition through the production of short chain fatty acids, and by interactions with the host immune system. The major nutrients available to these organisms are dietary glycans that are not metabolized by mammalian enzymes in the small intestines. Dietary and nutraceu ...
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 2

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Reversibility and tissue specificity of mitochondrial translation defects in early childhood (reversibleCOX)

Start date: Mar 1, 2013, End date: Feb 28, 2018,

We have recently identified the molecular genetic cause of a puzzling clinical syndrome, initially termed “benign infantile mitochondrial myopathy due to reversible cytochrome c oxidase (COX) deficiency”. While childhood-onset mitochondrial encephalomyopathies are usually severe, relentlessly progressive conditions with fatal outcome, this syndrome stands out by showing complete (or almost complet ...
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 1

 FINISHED 

Molecular basis of the outer membrane permeability (TRANSLOCATION)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

Overcoming the barriers that the cell envelope and efflux pumps provide to Gram-negative bacteria is a major bottleneck in the discovery and development of new antibiotics. To respond to this Call we are extending our current network on antibiotic translocation and propose an ambitious project ranging from identification of novel resistance mechanisms in clinical bacterial isolates to crystallizat ...
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 28

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Integrated European –omics research project for diagnosis and therapy in rare neuromuscular and neurodegenerative diseases (Neuromics)

Start date: Oct 1, 2012, End date: Sep 30, 2017,

Neurodegenerative (ND) and neuromuscular (NM) disease is one of the most frequent classes of rare diseases, affecting life and mobility of 500,000 patients in Europe and millions of their caregivers, family members and employers. This NEUROMICS project brings together the leading research groups in Europe, five highly innovative SMEs and relevant oversea experts using the most sophisticated Omics ...
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 20

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Universal Influenza Vaccines Secured (UNISEC)

Start date: Oct 1, 2013, End date: Sep 30, 2017,

UNISEC brings together a European consortium of 3 University partners, 5 National Health Institutes and 3 SMEs, all with leading expertise in influenza vaccine research and development, to work on promising recently developed concepts for a universal influenza vaccine. The consortium is exceptionally strong, interdisciplinary and intersectional in nature, and encompasses a unique combination of sc ...
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 15

 FINISHED 

MOLECULAR BASIS OF ANTIBIOTIC TRANSLOCATION (Translocation)

Start date: Sep 1, 2013, End date: Aug 31, 2017,

Multidrug resistant bacteria are now ubiquitous in both hospitals and the larger community. Drug-resistant pathogens are becoming increasingly pervasive, for example, the resurrection of tuberculosis provides one ominous example highlighting the risk associated with evolved drug resistance. Moreover, many pharmaceutical companies abandoned this field and no truly novel active antibacterial compoun ...
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 11

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Bacterial Persistence (PERSIST)

Start date: May 1, 2012, End date: Apr 30, 2017,

"Almost all bacterial species generate persisters, individual cells that are tolerant to antibiotics. Persisters have entered a dormant or slow growing state in which they are recalcitrant to the killing activity of most known antibiotics. The molecular mechanisms underlying bacterial persistence are unknown and there is a pressing need to develop new methods and approaches to study the phenomenon ...
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 2

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Advanced Training in Industrial Enzyme Manufacturing (ATRIEM)

Start date: Oct 1, 2012, End date: Sep 30, 2016,

"One of the main activities in the biotech industry is the manufacturing of enzymes, and access to cheap and diverse enzymes is crucial for the development of a sustainable biobased economy. However, improving the production efficiency of an increasingly large variety of commercial proteins and enzymes poses significant challenges for industrial-scale fermentations. In addition, the European biote ...
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 2

 FINISHED 

Life-like visual information processing for robust collision detection (LIVCODE)

Start date: Oct 1, 2012, End date: Sep 30, 2016,

"To be able to detected collision efficiently is of vital importance for the survival of animals that are migrating at speed, especially for those flying in dense swarms like locusts. Vision plays a critical role in collision detection for most animal species in a dynamic world. It is expected that in future, many human made machines, such like ground vehicles, mobile robots, and unmanned aerial v ...
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 3

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PERMETTRE LA MOBILITE DES JEUNES PAR UNE VALORISATION DES COMPETENCES ACQUISES GRACE AUX APPRENTISSAGES REALISES AU SEIN DE L’ESPACE EUROPEEN RENFORCER ET ENRICHIR LES PRATIQUES PROFESSIONNELLES DES EQUIPES ENGAGEES DANS UNE OUVERTURE A L'EUROPE

Start date: Jul 1, 2014, End date: Jun 30, 2016,

ALLOW THE YOUTH MOBILITY BY UPGRADING SKILLS ACQUIRED THROUGH LEARNING MADE WITHIN THE EUROPEAN SPACE The Regional Federation of MFR (FRMFR) in Brittany undertakes, in its mission of facilitating networks, eight MFR located throughout the Breton territory. The 161 young people involved in the Erasmus + program will go to twelve different countries: Switzerland, Ireland, Spain, Sweden, Poland, Port ...
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 165

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Consortium for Products across Europe in Duchenne Muscular Dystrophy (SCOPE-DMD)

Start date: Jun 1, 2013, End date: May 31, 2016,

"This project builds on results from the TREAT-NMD and BIO-NMD European projects to develop a personalised-medicinal product through to market for the treatment of Duchenne Muscular Dystrophy (DMD). DMD is an inheritable, childhood rare disease that affects approximately 1 in 3,500 newborn boys. This rare disease is caused by mutations in the dystrophin gene, resulting in the absence or defect of ...
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 5

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Addictions and Lifestyles In Contemporary Europe – Reframing Addictions Project (ALICE RAP)

Start date: Apr 1, 2011, End date: Mar 31, 2016,

ALICE RAP is a Europe wide project of 43 partner research institutions involving 107 researchers from 25 European countries providing 1000 months of a plurality of scientific endeavour to analyse the place and challenges of addictions and lifestyles to the cohesion, organization and functioning of contemporary European society. Through integrated multidisciplinary research, a wide range of factors ...
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 46

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The Plant Cell Wall Training Consortium (WallTraC)

Start date: Jun 1, 2011, End date: Feb 29, 2016,

"Plant cell walls constitute a highly complex and dynamic entity of extreme importance in plant growth and development. Growing cell walls can be considered as ""fibre composites"", where cellulose microfibrils are embedded in a matrix of complex glycans. It is becoming increasingly apparent (i) that cell wall glycans are diverse in structural terms, (ii) that these structures are developmentally ...
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 11

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Mechanisms of prevention of type 2 diabetes by lifestyle intervention in subjects with pre-diabetes or at high-risk for progression (DEXLIFE)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

"Type 2 diabetes (T2DM) is preventable by sustained changes in diet and physical exercise. Despite this, modern societies are already approaching 10% population prevalence of diabetes, and another 15% with pre-diabetes. The costs of T2DM are huge, approaching 10% of all health costs. Prevention of diabetes is a priority for national healthcare agencies and for the health insurance industry. Inve ...
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 12

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Treat Iron-Related Childhood-Onset Neurodegeneration (TIRCON)

Start date: Nov 1, 2011, End date: Oct 31, 2015,

Neurodegeneration with brain iron accumulation (NBIA) is a heterogeneous group of rare hereditary neurodegenerative disorders characterized by high levels of brain iron. The most common form is pantothenate kinase-associated neurodegeneration (PKAN). Classic PKAN and most other NBIA cases are characterised by early childhood onset and rapid progression. Currently, there is no proven therapy to hal ...
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 14

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Endoglin-Mediated Vascular Regeneration to Promote Heart Repair (VASC-GEN)

Start date: Jun 1, 2013, End date: May 31, 2015,

"The standard emergency treatment for myocardial infarction (MI) has so improved over the last decade that most patients survive. However, many of these patients still go on to develop heart failure over the subsequent months and years. Vascular regeneration using autologous cells, if given at an early stage in patient treatment, can promote cardiac repair following MI and reduce the adverse card ...
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 1

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Mechanisms of Transcription Proofreading (MTP)

Start date: Nov 1, 2008, End date: Oct 31, 2013,

Transcription, the copying of DNA into RNA, is the first step in the realisation of genetic information. RNA is either directly used by the cell or decoded into proteins during translation. The accuracy of transcription is thus essential for proper functioning of the cell. In all living organisms transcription is performed by multisubunit RNA polymerases, enzymes that are highly conserved in evolu ...
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 1

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Embryonic Stem cell-based Novel Alternative Testing Strategies (ESNATS)

Start date: Apr 1, 2008, End date: Sep 30, 2013,

"ESNATS aims at developing a novel toxicity test platform based on embryonic stem cells (ESC), especially human ESC (hESC), to accelerate drug development, reduce R&D costs and propose a powerful alternative to animal tests (3 Rs). ESNATS will address current drug-testing shortcomings: - testing takes place late in the development cycle - animal test systems bear the risk of non-prediction due to ...
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 34

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Molecular biology of cell wall regeneration in L-form bacteria (Regenerate)

Start date: May 2, 2011, End date: May 1, 2013,

Cell wall deficient (L-form) bacteria are thought to be important in various resistant, persistent or chronic infections. L-form cells are highly abnormal in size and shape and are sensitive to osmotic shock but highly resistant to antibiotics that work on the cell wall (e.g. penicillins and cephalosporins). How these unusual cells arise and how they proliferate in the absence of a wall, is poorly ...
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 1

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Exploring the fundamental biology of microsporidian mitosomes (MICMIT)

Start date: May 2, 2011, End date: May 1, 2013,

"Microsporidia are tiny obligate intracellular parasites of other eukaryotes including patients with HIV/AIDS. Despite their importance, detailed knowledge of the biology of microsporidia is limited. Microsporidia were thought to lack mitochondria but the proposed host laboratory discovered, and have started to functionally characterise, highly reduced remnant mitochondria in these parasites, cal ...
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 1

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Gene- Environment Interactions in Heart Development (CHeartED)

Start date: Jan 1, 2009, End date: Dec 31, 2012,

Cardiovascular malformation (CVM) is the commonest cause of childhood death in developed countries. In the EU there are 51,000 new cases each year and two million affected individuals. Yet, despite intensive research, the cause of 80% of CVM remains elusive. The mission of CHeartED is to identify genetic and environmental pathways that can be modified with the goal of reducing preventable CVM inci ...
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 11

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Improving Plant Cell Walls for Use as a Renewable Industrial Feedstock (RENEWALL)

Start date: Aug 1, 2008, End date: Jul 31, 2012,

"With oil reserves diminishing and the effects of industrial emissions on global climate, there is a need for renewable carbon-neutral industrial feedstocks. First generation biorefineries, producing biofuels and bioplastics by the fermentation of sugar or starch, are seeing a rapid expansion and are adding stress to food supplies. A more sustainable option is to use plant biomass from agricultura ...
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 17

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Pathophysiology and natural course of autoimmune adrenal failure in Europe (Euradrenal)

Start date: Apr 1, 2008, End date: Mar 31, 2012,

Autoimmune Addison’s disease (AAD) is an endocrine disease resulting from the immune system’s destruction of hormone producing cells in the adrenal cortex. Diagnosis is frequently first established after a life-threatening adrenal crisis, often resulting in untimely fatalities. The disease is rare, more common in women than in men, and also affects children. AAD very frequently occurs with other a ...
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 12

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Reductive evolution of parasite genomes with a focus on the microsporidian Trachipleistophora hominis (TraHomGen)

Start date: May 1, 2009, End date: Apr 30, 2011,

Trachipleistophora hominis is a member of the microsporidia, a large group of obligate intracellular parasites of other eukaryotes including patients with HIV/AIDS. Microsporidia were originally thought to be early-branching eukaryotes lacking mitochondria. Recent data, key elements published by the proposed host laboratory, have now shown that they are highly reduced fungi with largely metabolica ...
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 1