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RAS superfamily and the interactions with their effectors: functional specificity (Ras:effectors)
Start date: Sep 1, 2007, End date: Aug 31, 2009,
Ras genes code for small GTPases that act as GDP/GTP-regulated molecular switches. This exchange induces a conformational change that allows them to interact with their downstream effectors, and thus participate as central control elements in signal transduction. Mutated forms of the Ras oncoprotein are found in more than 30% of all human cancers, justifying the extensive research on them. Ra ...
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