Search for European Projects

29 European Projects Found

Searched on 125080 European Projects

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Hematopoietic stem cells (HSC) are used in clinical therapies for leukemia and blood-related genetic disorders. Whereasthe number of patients requiring treatment continues to increase, HSC transplantations are limited due to insufficientpatient-matched donor HSCs. The current challenge is to create more matched HSCs. As evidenced by the Nobel Prizeaward this year, reprogramming of somatic cells to ...
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This proposal is focused in the areas of chemical medicine and chemical biology with the key drivers being the discovery and development of new materials that have practical functionality and application. The project will enable the fabrication of thousands of three-dimensional “smart-polymers” that will allow: (i). The precise and controlled release of drugs upon the addition of either a small mo ...
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Vascular remodelling and miRNA therapeutics (VASCMIR)

Start date: Jul 1, 2014, End date: Jun 30, 2019,

The central hypothesis of VascmiR is that microRNAs (miRs) fundamentally control pathological remodelling of the vasculature. The complexity of vascular bed heterogeneity and subsequent response to injury, the potential importance of miRNA in vascular pathology and the paucity in knowledge relating to many facets of miRNA function in the vessel wall including target pathways, mechanistic features ...
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Engineering life: ideas, practices and promises (ENLIFE)

Start date: Sep 1, 2014, End date: Feb 28, 2019,

The emerging field of synthetic biology promises to engineer the living world. This is potentially extremely contentious, so scholars from the social sciences and humanities have been incorporated into synthetic biology research programmes from the outset. The ENLIFE project’s distinctive contribution will be to study both the engineering of biology and the role of social scientists within this. I ...
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This proposal details the mechanism-based discovery of ground-breaking new catalyst systems for a broad range of arylation processes that will be of immediate and long-lasting utility to the pharmaceutical, agrochemical, and materials chemistry industries. These industries have become highly dependent on coupling technologies employing homogeneous late transition metal catalysis and this reliance ...
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A Total Photon Camera for Molecular Imaging of Live Cells (TOTALPHOTON)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

"How can we construct a high-resolution camera capable of imaging the time-of-arrival, polarisation and wavelength of each of the maximal 10Gphoton/s emitted from a labelled, biological cell?Such a measurement would capture the complete information available in the optical signal, and significantly enhance our ability to observe the organisation, movement and interactions of cellular components at ...
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'Orbital molecules' - self-organised states for orbitronics (ORBITMOL)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

‘Orbital molecules’ are made up of coupled orbital states on several metal ions within an orbitally-ordered (and sometimes also charge-ordered) solid such as a transition metal oxide. Spin-singlet dimers (a weak metal-metal bond) are known in several materials, but recent discoveries of more exotic species such as 18-electron heptamers in AlV2O4 and 3-atom trimerons in magnetite (Fe3O4) have shown ...
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The Physics of Active Particle Suspensions (PHYSAPS)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

... eria can have a viscosity that is lower than that of the suspending liquid. There is yet no gener- ally accepted statistical mechanics of active matter, where the absence of detailed balance means that small differences in microscopic dynamics can in principle lead to very different macroscopic behaviour. Moreover, there is no a priori reason to believe that a reduced description in terms of just ...
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Wall-crossing and Birational Geometry (WALLXBIRGEOM)

Start date: Dec 1, 2013, End date: Nov 30, 2018,

We will use modern techniques in algebraic geometry, originating from string theory and mirror symmetry, to study fundamental problems of classical flavour. More concretely, we apply wall-crossing in the derived category to the birational geometry of moduli spaces.Bridgeland stability is a notion of stability for complexes in the derived category. Wall-crossing describes how moduli spaces of sta ...
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"Although protein dynamics plays an essential role in function, it is rarely considered explicitly in current structure-based approaches to drug design. Here I propose the computer-aided design of ligands by modulation of protein dynamics, or equivalently, protein structural ensembles. The detailed understanding of ligand-induced perturbations of protein dynamics that will result from this study i ...
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Transmembrane Molecular Machines (TRANSPORET)

Start date: Sep 1, 2013, End date: Aug 31, 2018,

This research programme is dedicated to the development of rationally designed transmembrane molecular machines. Proteins that undergo nanomechanical transitions to facilitate transmembrane communication, or that operate as transmembrane pumps, rotary motors, and molecular transporters are ubiquitous in nature. Despite much progress in the development of solid-state and chemical nanomechanical dev ...
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Evaluation Practices in Financial Markets (EPIFM)

Start date: Sep 1, 2012, End date: Aug 31, 2018,

EPIFM will be a social-science (rather than, as conventionally, an economic) investigation, by a team bridging science and technology studies (STS), sociology and politics, of how professional participants in financial markets evaluate financial instruments such as shares and bonds. These evaluation practices are crucial to the operation of financial markets (they help determine the activities to ...
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Combinatorial methods in noncommutative ring theory (COIMBRA)

Start date: Jun 1, 2013, End date: May 31, 2018,

As noted by T Y Lam in his book, A first course in noncommutative rings, noncommutative ring theory is a fertile meeting ground for group theory (group rings), representation theory (modules), functional analysis (operator algebras), Lie theory (enveloping algebras), algebraic geometry (finitely generated algebras, differential operators), noncommutative algebraic geometry (graded domains), arithm ...
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The physical conditions of molecular gas in galaxies, and the impact of star formation and AGN on these conditions and on the emergent stellar IMF, are overarching themes in astrophysics. We are entering an era where numerical simulations of turbulent molecular gas can be informed and constrained by observations of such gas. I propose to investigate, theoretically and observationally, the impact o ...
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Paget’s disease of bone (PDB) is a common disease characterised by focal areas of increased bone turnover leading to symptoms of bone pain, deformity, osteoarthritis and other complications. Genetic factors play an important role in PDB and mutations in SQSTM1 gene are responsible for ~10% of PDB cases with high penetrance. We have recently identified seven additional susceptibility loci for PDB u ...
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The centromere is one of the most important chromosomal elements. It is required for proper chromosome segregation in mitosis and meiosis and readily recognizable as the primary constriction of mitotic chromosomes. Proper centromere function is essential to ensure genome stability; therefore understanding centromere identity is directly relevant to cancer biology and gene therapy. How centromeres ...
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Rule-Based Modelling (RULE)

Start date: Feb 1, 2013, End date: Jan 31, 2018,

The purpose of this research programme is to contribute to the solution of a major problem in today’s systems biology: namely, the difficulty to bring mechanistic modelling to bear on full scale systems. Statistical, and experimental techniques have scaled up considerably in the last two decades. Mechanistic modelling, on the other hand, is still confined in much smaller scales. Witness the painst ...
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The research proposed here will use a novel and fully-integrated data-modelling approach to provide a step-change in our understanding of the nature and drivers of climate variability and change on the societally-relevant timescales of decades to centuries. Identifying the causes of observed changes in climate requires an understanding of the natural, internally generated variability of the clima ...
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Non-coding RNA pathways and the mammalian male germline (NCRNA)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

The integrity of the genome transmitted to the next generation intrinsically relies on germline cells. Processes ensuring germ cell development, genomic stability and reproductive lifespan are essential for the long-term success of a species. Spermatogonial stem cells (SSCs) support spermatogenesis throughout life, the identity of this mammalian adult stem cell population in vivo remains unknown. ...
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Visual Culture for Image Understanding (VISCUL)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

The goal of computer vision is to interpret complex visual scenes, by recognizing objects and understanding their spatial arrangement within the scene. Achieving this involves learningcategories from annotated training images. In the current paradigm, each category is learned starting from scratch without any previous knowledge. This is in contrast with how humans learn, who accumulate knowledge a ...
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Cellular pathways determining growth and human brain size (HUMGENSIZE)

Start date: Nov 1, 2012, End date: Oct 31, 2017,

The greatest differences between mammals are size. As well, the large evolutionary expansion of the cerebral cortex is a defining feature humans. Despite this, much remains to be learnt about the developmental and evolutionary factors controlling organ and organism size. This is in marked contrast to the exquisite detail in which developmental patterning has been defined in model organisms. The i ...
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Computational modelling is changing the face of science. Many complex systems can be understood as embodied computational systems performing distributed computations on a massive scale. Biology is the discipline where these ideas find their most natural application: cells can be viewed as input/ output devices, with proteins and organelles behaving as finite state machines performing distributed c ...
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We aim to develop and apply a suite of new technologies in a novel cancer discovery platform that will link high-definition cancer biology, via state-of-the-art disease imaging and pathway modelling, with development of novel interrogative and therapeutic interventions to test in models of cancer that closely resemble human disease. The work will lead to a new understanding of cancer invasion, how ...
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Recent genetic studies have identified hundreds of susceptibility genes for common human diseases but genetic effects are small and identifying underlying mechanisms remains challenging. Rodent models offer significant advantages for analysis of disease phenotypes. Advances in genome resources and gene targeting have increased the attractiveness of the rat model for genetic studies but progress ha ...
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The Sasanian Empire (3rd-7th c. AD) stretched from Mesopotamia to the west of the Indian Subcontinent. A pilot study has shown that major frontier walls and geometrical fortifications, whose scale and sophistication surpasses those in contemporary Europe, date to the Sasanian era, as do grand urban foundations and canal systems. Yet, excavations and surveys of Sasanian monuments have been far and ...
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Microbes evolve rapidly in changing environments, and global change may soon cause future microbial populations to differ genetically and phenotypically from contemporary populations. We have both pragmatic and intellectual interests in microbial evolution, especially when microbial communities perform important ecological services. For example, marine phytoplankton are responsible for half of glo ...
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Investigating Networks of Zoonosis Innovation (INZI)

Start date: Mar 1, 2012, End date: Feb 28, 2017,

INZI aims to analyse the complex interplay of actors, policies and projects that have shaped research into and control of Human African Trypanosomiasis (HAT) until the present day. Research has mainly been steered from outside of Africa, firstly by colonial authorities and latterly by an array of agencies, foundations and international organisations. Despite this, investment in research and contro ...
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This proposal is concerned with simulation-based approaches to sound synthesis, in the interest of generating very high quality synthetic sound of a natural acoustic character—partly to emulate real instruments, but also to explore classes of sounds which cannot be produced using conventional synthesis methods, or acoustic instruments. A further goal is to introduce such physical modelling synthes ...
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Studying the nature of the first generation of galaxies to form in the Universe is central to efforts to understand the earliest phases of galaxy evolution and the physical processes driving cosmic reionization. Building on my recent success investigating galaxy evolution at redshifts z>6, I propose to recruit and lead the research team necessary to fully exploit my involvement in two Hubble Spa ...
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