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The regenerative power of a living organism is linked to the potential of its stem cells to replace the corresponding damaged tissue. Therefore organisms are as old as their stem cells. Whereas the vulnerability to cancer and chronic inflammation is associated with a decline of the immune system, the latter is in turn a sum product of interactions among hematopoietic stem cells (HSC), endothelial ...

"Chronic heart failure (CHF) is a massive clinical, social and economic problem. Diabetes and obesity increase the risk of developing CHF. Cachexia is also an ominous sign. In 13 clinical and preclinical research projects, SICA-HF aims to investigate the impact of these co-morbidities in CHF patients at the clinical, vascular, cellular and molecular levels. SICA-HF will enrol >1600 patients wit ...