4 European Projects Found
Searched on 125080 European Projects
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Role of the PI3Kbeta isoform in signalling and cancer invasion (PIKbeta/cancer)
Start date: Apr 1, 2011, End date: Sep 28, 2013,
PI 3-kinases (PI3Ks) generate lipids in cell membranes which bind a variety of intracellular protein effectors, affecting their localization and/or activity. The PI3K signalling axis is one of the most frequently deregulated pathways in cancer. Mammals have 8 isoforms of PI3K, divided into three classes. The class I PI3Ks consist of a p110 catalytic subunit (p110alpha, p110beta, p110delta and p110 ...
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Roles of Class I PI 3-kinase isoforms in signalling and cancer (PI3K/signal-cancer)
Start date: Oct 1, 2010, End date: Mar 9, 2013,
PI 3-kinases (PI3Ks) generate intracellular lipid second messengers that regulate many cellular processes including cell survival, proliferation, migration and differentiation. The PI3K signalling pathway has been implicated in diseases such as cancer, inflammation and diabetes, and PI3Ks are therefore considered as attractive new therapeutic targets in the pharmaceutical and biotech industry. Mam ...
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In-depth quantification and characterisation of PI 3-kinase signalling networks at a System Biology level (PI3K Systems Biology)
Start date: Jan 1, 2011, End date: Dec 31, 2012,
The group of genes termed phosphoinositide 3-kinase (PI3K for short) have roles in many important biological functions and are also implicated in diseases such as diabetes, inflammation, allergy and cancer. Therefore, there are many pharmaceutical and biotechnological companies interested in targeting this pathway. There are 8 different PI3K genes and it is becoming clear that they have different ...
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Characterization of signalling and physiologic roles of the class II PI 3-kinases (PI3KC2)
Start date: Aug 1, 2010, End date: Jul 31, 2012,
"Phosphoinositide 3-kinases (PI3Ks) are a conserved family of lipid kinases that generate lipid second messengers inside cells. Mammals have 8 isoforms of PI3K, divided in three classes (I, II and III). The focus of research has thus far almost exclusively been on class I PI3Ks, which have been implicated in cancer, inflammation and diabetes and which are the target of ongoing drug development eff ...
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