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3 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Exploring the role of mitochondrial dynamics in tumor regulation by Cop1 (Cop1-Drp1)

Start date: Apr 1, 2012, End date: Mar 31, 2014,

The Constitutive morphogenetic protein 1 (Cop1) is an E3-ubiquitin ligase regulating stability of a broad group of targets with pleiotropic functions. Cop1 emerged as a tumour suppressor in T-cell lymphomas and in prostate cancer. During tumour formation, mitochondria are key organelles regulating cell death and proliferation. This multiplicity of functions is mirrored by the complex morphology of ...
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 FINISHED 

Regulation of mitochondria-endoplasmic reticulum tethering by Parkin: implication for Parkinson’s disease (Mitofusin-PD)

Start date: Mar 1, 2012, End date: Feb 28, 2014,

Parkin, an E3 ubiquitin ligase and a Parkinsons's disease related gene, translocates to impaired mitochondria upon mitochondria intoxication and drives their elimination via autophagy, a process known as mitophagy. Mitochondrial pro-fusion protein Mitofusin (Mfn) was found to be a target for Parkin mediated ubiquitination. In absence of Parkin, Mfn fails to be ubiquitinated, thus accumulates in th ...
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 FINISHED 

Role of mitochondria-shaping proteins in T cell development and migration in vivo (Dyna-Mito in Thymus)

Start date: Jan 1, 2010, End date: Dec 31, 2011,

Mitochondria are highly dynamic organelles that continuously move, divide and fuse in a highly regulated fashion. The balance between the opposing processes of mitochondrial fusion and fission is controlled by a growing family of “mitochondria-shaping” proteins. Evidence is accumulating on the role of these proteins in several functions, from apoptosis to Ca2+ signaling, to morphogenesis of dendri ...
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