20% of all paediatric cancer remains incurable
Long term side effects associated with treatment
Cancer is often much more advanced, i.e., metastatic, in children then adults
Effective and safe treatments are urgently needed
Build a comprehensive translational network of PDX models, matching cell lines/organoids and genetically modified mouse models with complete molecular characterization and proven relevance to major solid paediatric tumours.
Increasing the number of cures across a wide range of paediatric cancer histologies (more lives saved);
Potentially mitigating the long term health effects typically associated with conventional chemotherapeutic, better quality of life