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Biomanufacturing 2020: Development of Innovative high throughput analytical tools and methods to characterize cell culture fluid during development and commercial cell culture processes - IMI2-2016-10-05
Deadline: Sep 14, 2017  
CALL EXPIRED

 Genetic Resources
 Health Care
 Medical equipment
 Biotechnology
 E-Health
 Medical Biotechnology
 Horizon Europe
 Research

Specific Challenge:

Industrial Animal Cell Technology has become a well-established platform for biopharmaceutical production. However, substantial issues remain, calling for increased research and innovation. The absence of predictive tools and the poor understanding of how bioprocesses impact cell and protein quality increase production risks and costs. There is a need for the development of innovative analytical technology, leading to faster, leaner, more controllable, cost-effective and more industrious production. This should lead to more effective products manufactured by predictive, economic and competitive processes and thus to more cost savings that benefit both industry and healthcare systems, whilst ensuring safety.

Scope:

The overall objective is to develop/determine the best high throughput or novel analytical and/or feedback control methods/tests to be used for the parameters that need to be measured during manufacturing of biopharmaceuticals, in particular the cell culture.

Expected Impact:

  • Innovative analytical tools developed by academic partners and SMEs can get translated, validated and implemented at larger companies for commercial purposes
  • Creation of spin-offs specialized in these analytical tools.
  • More effective control and execution of the production phase and will lead to the qualitative and consistent manufacturing of biopharmaceutical therapies
  • Increase supply chain reliability and reduce drug shortages


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