A 1,000 healthy donors cohort to define Immune Response variability

Created on 23 May 2017

Milieu Intérieur consortium

Research Institute

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The Milieu Intérieur project, "Genetic & Environmental Determinants Of Immune Phenotype variance: Establishing A Path Towards Personalized Medicine", is an ambitious population-based study coordinated by the Institut Pasteur, Paris. The objective is to dissecte the interplay between genetics and environment and their impact on the immune system.

The objectives of the Milieu Intérieur project are to: 

  • Establish a deep understanding of immune variance; 
  • Define how immune phenotypic variation is genetically controlled and;
  • Ascertain the role of the microbiota in regulating immune programs.

A de novo study-group of 1,000 healthy individuals (1:1 sex ratio) stratified across five-decades of life (age 20 – 70) from French-descent and recruited as per a detailed medical questionnaire has been recruited between September 2012 and August 2013. Whole blood was collected for immunologic phenotyping, functional immune stimulation and preparation of DNA for genomic analysis. Fecal samples and nasal swabs were obtained for metagenomic studies. Punch biopsies of the skin were taken and primary fibroblast lines were generated for future mechanistic investigation.

One innovative aspect of the project relies on the use of a whole-blood assay device - TruCulture® - which preserves physiological cellular interactions and provides a reproducible means of assessing the complexities of innate and adaptive human immune responses.
A total of 32 different immune stimuli conditions have been selected and whole blood assays have been validated and produced.

The Milieu Intérieur project is actively looking for collaborative partnerships from public, private and NGO sectors.
We are very open to industrial partners who may be interested by the MI data warehouse and sample repositry, or looking to perform parallel sub studies focused on their specific disease area of interest.

Based on our systems biological approach to understanding the Immune Response, many different scientific collaborations can be envisioned. For example:

- Defining perturbed immune phenotypes in disease

- Vaccine and adjuvant development

- Development of leading edge ex vivo point-of-care diagnostics and theranostics that monitor function of immune response

- Establishing correlates between flora, host genetics and host response

- Partnership on studying population-based response to immune modulators

- Help exploit phenotype – genotype associations (immune modulators, cancer susceptibility)

- Research collaboration for companion biomarker studies in defined patient populations

 


 Biological Sciences
 Biotechnology
 Innovation & Research
 Medical Biotechnology
 Biology
 Biostatistics

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