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DEVELOPMENT AND APPLICATIONS OF NEW YLID CHEMISTRY (YLIDXCHEM)
Start date: Jul 1, 2009, End date: Jun 30, 2011 PROJECT  FINISHED 

"The aims of this research are to develop efficient synthetic methodology for one-pot catalytic cross-metathesis/tandem oxonium ylide formation– [2,3] sigmatropic rearrangement of unsaturated diazocarbonyl substrates, to establish a pool of useful chiral catalysts for this chemistry, and to apply this methodology in strategies for the enantioselective synthesis of selected biologically active natural product classes. The objectives are: Development and scope of one-pot cross-metathesis/tandem oxonium ylide formation– [2,3] sigmatropic rearrangement New catalyst preparation and evaluation in enantioselective tandem ylide formation – rearrangement Development of asymmetric synthesis strategies to hyperolactone anti-HIV agents"
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