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2 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Structural Basis of Ubiquitin Protein Ligation (UBLIGATION)

Start date: Sep 1, 2010, End date: Aug 31, 2014,

"The attachment of Ubiquitin (Ub) to proteins (ubiquitination) is one of the most abundant post‐translational modifications in eukaryotes. Deregulation of the ubiquitination reaction is the cause of various diseases, including cancer. Ubiquitination is catalyzed by the sequential action of an activating (E1), a conjugating (E2), and a ligating (E3) enzyme. Ubiquitination enzymes contain catalytic ...
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 FINISHED 

Molecular mechanisms of mRNA decay (mRNA decay)

Start date: Jul 1, 2009, End date: Jun 30, 2013,

All organisms require a reliable mechanism to turn genes on and off. This regulation of gene expression underlies cellular processes ranging from the response to environmental signals to the development of multi-cellular organisms and cell-cell communication. Understandably, the cell tightly controls gene expression at every step from DNA to protein. Recent work has given new insights into these c ...
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