Search for European Projects

5 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Innovative drugs targeting IDO molecular dynamics in autoimmunity and neoplasia (DIDO)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

"Catabolism of amino acids is an ancient survival strategy that also controls immune responses in mammals. Indoleamine 2,3-dioxygenase (IDO), a tryptophan catabolizing enzyme, is recognized as an authentic regulator of immunity in several physiopathologic conditions, including autoimmune diseases, in which it is often defective, and neoplasia, in which it promotes immune unresponsiveness. The PI’s ...
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 FINISHED 

Genetic High Throughput Screenings by random mutagenesis to identify Plasmodium falciparum critical genes for asexual growth, sexual differentiation and virulence affecting host immune responses (GeneticHTS reveal Pf)

Start date: Feb 1, 2011, End date: Feb 21, 2018,

Malaria is a global health problem that demands immediate practical actions to contain the high infection and mortality rates caused by Plasmodium species. Protective vaccine is still missing. Available drugs diminish their impact against Plasmodium as resistances are rising and expanding on the territories. While no vaccine of the current portfolio showed ideal protection and low-cost feasibility ...
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 2

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Metabolomics of fungal diseases: a systems biology approach for biomarkers discovery and therapy (FunMeta)

Start date: Apr 1, 2012, End date: Mar 31, 2017,

Humans have evolved intimate symbiotic relationships with a consortium of gut microbes (including fungi) and individual variations in the microbiome influence host health and disease. The fact that fungi are capable of colonizing almost every niche within the human body suggests that they must possess particular immune adaptation mechanisms, the breakdown of which may result in fatal fungal infect ...
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 3

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"Fungi in the setting of inflammation, allergy and autoimmune diseases:Translating basic science into clinical practices" (ALLFUN)

Start date: Dec 1, 2010, End date: May 31, 2014,

"The ALLFUN proposal aims at defining the cellular and molecular mechanisms by which ubiquitous airborne or commensal fungi contribute to immune homeostasis and its dysregulation leading to allergy and inflammatory diseases. Breakthroughs in understanding how mucosal homeostasis is established, maintained or disrupted in the presence of fungi should be sources of new therapeutic targets and drugs ...
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Correlating protection against malaria with serum profiles against Plasmodium falciparum antigen repertoires (FIGHTMAL)

Start date: Jun 1, 2008, End date: May 31, 2012,

"People living in malaria endemic areas develop, with time, a form of immunity to infection and clinical disease mediated by antibodies directed against P. falciparum antigens. Currently there are no assays or clinical parameters that predict whether an exposed person is protected against malaria. This represents a major obstacle for vaccine development. Here research institutions and industrial p ...
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