4 European Projects Found
Searched on 125080 European Projects
FINISHED
European Medical Information Framework (EMIF)
Start date: Jan 1, 2013, End date: Dec 31, 2017,
In response to the need to tackle increasingly complex medical research questions, a growing amount of human health data is being collected, either in routine Electronic Healthcare Record (EHR) databases, through research-driven cohort studies, in biobanks or related efforts. However, data sources are typically fragmented and contain information gaps which prevent their full exploitation. EMIF aim ...
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64
Partners Participants
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Safety Evaluation of Adverse Reactions in Diabetes (SAFEGUARD)
Start date: Oct 1, 2011, End date: Sep 30, 2015,
"In 2010 a widely marketed drug for the treatment of type 2 diabetes (T2DM) (rosiglitazone) was taken from the market as it was associated with an increased risk of myocardial infarction, a T2DM complication it was actually supposed to prevent. This example shows several things. First, the approval requirements do not guarantee a longer term positive benefit risk profile. Second, large scale postm ...
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19
Partners Participants
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Arrhythmogenic potential of drugs (ARITMO)
Start date: Jan 1, 2010, End date: Jun 30, 2013,
The ability of some compounds to prolong the QT interval of the electrocardiogram and to precipitate Torsade de Pointes (TdP, a potentially fatal arrhythmia) has caused several regulatory interventions, including drug withdrawals. Specific guidelines have been implemented to detect QT liability of new compounds as early as possible. However there is growing evidence that an increase in the QT inte ...
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21
Partners Participants
FINISHED
Safety Of non-Steroidal anti-inflammatory drugs (SOS)
Start date: Nov 1, 2008, End date: Apr 30, 2012,
"The Safety Of non-Steroidal anti-inflammatory drugs (SOS) proposal aims to assess the relative cardiovascular (CVD) and gastrointestinal (GI) safety of non-steroidal anti-inflammatory drugs (NSAIDs). The NSAIDs are divided in traditional NSAIDs (tNSAIDs) and the newer COX-II inhibitors(coxibs). The aim will be fulfilled by a two-phase approach comprising systematic reviews and synthesis of CVD an ...
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