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2 European Projects Found

Searched on 125080 European Projects

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TGF-beta signaling in colorectal cancers (TGFb in CRC)

Start date: Mar 16, 2009, End date: Mar 15, 2011,

Colorectal cancer (CRC) is a leading cause of cancer-related death in western countries. TGFb are a family of signaling molecules delivering crucial tumor-suppressive signals to different cell types. Lack of TGFb induced cytostasis is a hallmark of cancer, and mutations of key transducers of TGFb in Colorectal cancer (CRC), albeit found only in a subset of tumors, indicates a leading role for thes ...
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Smad4-Ubiquitination by opposing E3 and DUB activities: a central control element in TGF-beta signaling (Enzymes for Smad4-Ub)

Start date: Feb 1, 2009, End date: Jan 31, 2011,

The research here outlined deals with the relevance of ubiquitination in TGF-beta growth factor signalling. As outlined below (subchapters) TGF-beta signalling is fundamental for embryonic development and for a variety of human pathologies. In particular, recent data showed that tuning TGF-beta signalling is essential for differentiation of pluripotent cells and for cancer and metastasis. The prop ...
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