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The resurgence of tuberculosis (TB) has been underway for almost 20 years, and despite increasingly implemented comprehensive control strategies, the epidemic in sub-Saharan Africa is continuing to expand. There is an urgent need to elucidate the reasons underlying the failing of TB control and to develop innovative public health approaches.This proposal aims to use a variety of epidemiologic meth ...

This proposal is for a large scale collaborative project in which we propose both to develop novel microbicides directed against new intracellular targets and to investigate novel combinations of highly active anti-retroviral drugs which may be particularly effective as microbicides. Combinations may enhance efficacy but equally importantly will increase the genetic barrier to the development of r ...