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A pharmacogenomic approach to coumarin anticoagulant therapy (EU-PACT)

Start date: Oct 1, 2008, End date: Mar 31, 2013,

"The effectiveness of treatment with oral anticoagulants in the prevention of thrombotic disorders is well established, but these drugs are potentially dangerous because of their narrow therapeutic index. In Europe three coumarins are used: warfarin, acenocoumarol, and phenprocoumon. Genetic factors that have been recently demonstrated to change the pharmacokinetics and pharmacodynamics of coumari ...
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