6 European Projects Found
Searched on 125080 European Projects
FINISHED
Spatiotemporal regulation of epidermal stem cells by circadian rhythms: impact on homeostasis and aging (STEMCLOCK)
Start date: Jan 1, 2013, End date: Dec 31, 2017,
"Most adult stem cells are compartmentalized in functionally deterministic niches where they self-renew and maintain homeostasis. From there, stem cells are instructed by combinations of signals and spatial tensile forces which they translate into a specific behavior. However how stem cells spatiotemporally coordinate their stem cell potential with niche- and systemic cues is poorly understood. Th ...
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3
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Modelling Cancer Traits in Drosophila (FliesCan)
Start date: Jul 1, 2012, End date: Jun 30, 2017,
Despite significant advance, cancer treatment remains suboptimal. Anatomical and physiological differences between humans and simple model organisms like Drosophila are many and major, and preclude the modelling of key aspects of the disease as it proceeds in vertebrates. However, malignant tumors in vertebrates and flies are made of cells that have derailed from their normal course of development ...
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2
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Advanced multiscale simulation of DNA (simDNA)
Start date: Jul 1, 2012, End date: Jun 30, 2017,
The availability of new computers and software is making possible the theoretical representation of DNA, increasing then our knowledge on the behavior of one of the most relevant biological macromolecules. Unfortunately, current simulation procedures present two major problems, which handicapped their use: i) classical force-fields present well known biases, which limit their accuracy; ii) current ...
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2
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Signal integration and rewiring during tumor development (p38Cancer)
Start date: Jul 1, 2012, End date: Jun 30, 2017,
Cell fate decisions rely on signaling pathways that integrate external signals to coordinate specific intracellular programs. One of these pathways leads to the activation of p38α MAPK, which plays key roles in cell responses to many types of stresses as well as chemotherapeutic agents and oncogenes. Importantly, p38α acts in a cell context-specific and cell type-specific manner to integrate signa ...
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2
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Testing and validation of bispecific antibody combinations targeting treatment-resistant cancer stem cells using organoid-based screening tools: a new drug discovery paradigm (SUPPRESSTEM)
Start date: Jun 1, 2013, End date: Nov 30, 2016,
Colorectal cancer (CRC) was diagnosed in 1.23 million people worldwide (EU 333,000) in 2008 and 608,000 (EU 148,000) died of the disease. While some new treatments have been advanced in CRC many have failed clinical testing; metastatic CRC is still largely incurable.In CRC, Cancer Stem Cells (CSC) are responsible for tumour progression and resistant to standard chemotherapies. The Wnt signal trans ...
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5
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Development of a new methodology for the synthesis of mercapto amino acids for protein synthesis by cysteine-free native chemical ligation (CYSTEINE-FREE NCL)
Start date: Apr 14, 2014, End date: Apr 13, 2016,
Proteins are in the heart of almost every single biological function and therefore are essential tools for drug discovery. Although the use of recombinant DNA techniques has been successfully applied to the synthesis of many proteins, the access to proteins bearing non natural amino acids, naturally obtained through post-translational modifications, remains limited. However, with the invention of ...
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