Archive of European Projects

36 European Projects Found

Searched on 125080 European Projects

 ONGOING 
... opean pharmaceutical manufacturing industry as it continues to face increased competition from other economiesIn order to achieve this aim we need to bring together expertise in(i) Organic Synthesis [Royal College of Surgeons in Ireland, “RCSI”](ii) Enantioselective fluorination [Nagoya University Japan, “Nagoya”](iii) Drug development and production [Integrated Research in Biotechnology & Medicin ...
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Ireland’s leading university, Trinity College Dublin (TCD), in partnership with the Royal College of Surgeons in Ireland (RCSI), is seeking funding to plan, promote and host Discover Research Night as part of European Researchers’ Night in 2014 and 2015. On Discover Research Night 26 September 2014 and 25 September 2015, TCD and RCSI will offer the general public a wide range of interactive and ha ...
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 ONGOING 
... cular bypass in a large animal model. This fellowship will have an outgoing phase to Prof David Vorp’s Lab at the University of Pittsburgh and a return phase to Prof Fergal O’Brien’s Lab at the Royal College of Surgeons in Ireland. Having recently completed my PhD, which focused on the mechanical and morphological characterisation of human diseased vascular tissue, this fellowship will allow me to ...
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 ONGOING 
... es encoding key inflammatory mediators such as Toll-like receptor 4 (TLR4) and tumour necrosis factor a receptor associated factor-6 (TRAF6). This highly innovative proposal, to be implemented at the Royal College of Surgeons Ireland (RCSI), aims to study the regulation of key miRNAs by estrogen and investigate if this plays a role in the CF gender gap. I will combine my own expertise in pulmonary ...
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 ONGOING 
... d counseling in employment for intellectual disability. ASSISTID COFUND will operate from a collaborative, international research institute (DOCTRID) encompassing all 7 of the Irish Universities, the Royal College of Surgeons in Ireland, the Northern Ireland Universities, Michigan State University, University of Massachusetts Medical School, OCAD University Canada, and the Intellectual Disability ...
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 FINISHED 
... s, the scientific goal of this proposal is to integrate my tools for temporally-controlled drug delivery with the existing collagen-based scaffold developed in Prof. Fergal O’Brien’s group at the Royal College of Surgeons in Ireland (RCSI). The proposed novel scaffold will be used to deliver vascular bioagents to DFUs, with ultrasound used as a trigger to delay the delivery of a vascular maturatio ...
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 ONGOING 
... quartered in the National University of Ireland, Galway (NUIG), and composed of multiple academic partners from around Ireland (NUIG, University College Dublin (UCD), University College Cork (UCC), Royal College of Surgeons in Ireland (RCSI), Molecular Medicine Ireland) and 35+ industry partners. MedTrain will offer 31 prestigious two-year postdoctoral fellowships for incoming mobility to eligible ...
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 ONGOING 
In sub-Saharan Africa 95% of the population has no access to surgical services. In this region surgery – a proven and often life-saving intervention – is only accessible to urban populations, with only one surgeon per 2.5 million people in rural areas. Emerging evidence demonstrates that major surgery can be undertaken safely and effectively at district hospitals, making it accessible to otherwise ...
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 ONGOING 
Colorectal cancer (CRC) is the 3rd most common cancer in Europe, and with approximately 200,000 deaths per year, it remains the 2nd most common cause of cancer death. More than half of all CRC patients develop distant metastases and have 5-year overall survival (OS) of less than 5% because of ineffective treatments. Increased understanding of cancer biology, coupled with the implementation of “omi ...
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 13

 ONGOING 

Water - Sustainable Point-Of-Use Treatment Technologies (WATERSPOUTT)

Start date: 01 Jun 2016, End date: 31 May 2020,

The WHO estimates that in 2015 in Africa ~156 million people relied on untreated sources for their drinking water. WATERSPOUTT will design, develop, pilot and field-test a range of, sustainable point-of-use solar disinfection (SODIS) technologies that will provide affordable access to safe water to remote and vulnerable communities in Africa and elsewhere. These novel large-volume water treatment ...
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 18

 ONGOING 

Endoplasmic Reticulum Stress in Health and Disease (TRAIN-ERS)

Start date: 01 Oct 2015, End date: 30 Sep 2019,

Endoplasmic reticulum (ER) stress is emerging as a common feature in the pathology of numerous diseases including cancer, neurodegenerative disorders, metabolic syndromes and inflammatory diseases. Thus ER stress represents a potential therapeutic intervention point to be exploited to develop novel therapies, diagnostic tools and markers for these diseases. However, exploitation is hampered by the ...
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 12

 ONGOING 
Diabetes mellitus is a chronic disease characterised by high blood glucose due to inadequate insulin production and/or insulin resistance which affects 382 million people worldwide. Pancreatic islet transplantation is an extremely promising cure for insulin-sensitive diabetes mellitus (ISDM), but side effects of lifelong systemic immunosuppressive therapy, short supply of donor islets and their po ...
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 FINISHED 
"Immune system response is the most complex barrier to long-term success of tissue transplants/implants from allogeneic and bio-artificial sources. While newly developed tissue transplant procedures are not yet performed frequently enough for robust analysis of adverse immune responses in humans, corneal transplantation (CT) is a well-established allogeneic tissue transplant with >100,000 full- an ...
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 FINISHED 
Skin diseases and disorders are among the most common health problems worldwide and are associated with a considerable burden. It encompasses psychological, social and financial consequences not only on the patients, but also on their families and on society. Chronic and incurable skin diseases/disorders, such as bullous disorders, fibrosis and ulcers, are associated with significant morbidity in ...
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 FINISHED 
Novel treatment options and associated personalised, patient-tailored therapies need to be explored and developed for highly heterogeneous and chemotherapy resistant cancers, such as malignant melanoma. This can only be achieved by industry-academia collaborations in newly emerging, innovative research disciplines such as translational cancer systems biology and systems medicine. These disciplines ...
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 FINISHED 
Epilepsy is a major burden for patients and health systems worldwide. It is a common chronic neurological disorder affecting people of all ages, and the shortfall in existing treatments means that 30% of patients continue to suffer uncontrolled seizures. MicroRNAs (miRNA) are a recently-discovered, network-level layer of gene expression regulation that controls protein levels of entire signaling p ...
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 FINISHED 
Biodegradable and biocompatible nanoparticles have high potential as viable carriers of active compounds in a broad range of applications for example for cosmetic ingredients as well as therapeutically active compounds such as vaccines, genes, drugs and other biomolecules (drug delivery). To advance current polymer nanoparticle technology we propose a novel nanomaterial platform based on synthetic ...
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 FINISHED 
Advanced nanotechnology-based materials offer new solutions to the challenges associated with the non-specific delivery of therapeutics that leads to ineffective treatments, especially in oncology. Currently, both therapeutic and diagnostic molecules are administered systemically, increasing the likelihood of unwanted side effects. THERAGEL will develop a novel delivery system that enables selecti ...
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 FINISHED 
Near-infrared (NIR) fluorescence molecular imaging is a supra-discipline that enables visualisation of cellular function and real-time tracking of molecular processes in living organisms without perturbing them. If exploited to its maximum potential, NIR-fluorescence could have hugely positive impact for early stage diagnosis of diseases such as cancer, neurological and cardiovascular disease, th ...
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 FINISHED 
Glycoprotein therapeutics are widely seen as the next generation of drugs. 80% of new therapeutic drugs in phase 3 development are ‘biologics’. However, the early detection of critical glycosylation changes in biopharma pro-duction (i.e. in the drug producing cells) and the rapid and sensitive identification and separation of closely relat-ed protein-drug glycoforms presents an industry wide probl ...
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 FINISHED 

Advanced Materials for Cardiac Regeneration (AMCARE) (AMCARE)

Start date: 01 Nov 2013, End date: 31 Oct 2017,

The Advanced Materials for Cardiac Regeneration (AMCARE) consortium aims to establish a translational research program to develop truly restorative therapies for acute myocardial infarction repair (MI) by optimising cardiac progenitor cell (CPC) therapy using smart biomaterials and advanced drug delivery, and coupling these therapeutics with minimally-invasive surgical devices. Two distinct biomat ...
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 FINISHED 
Description Innovative solutions for COPD multi-morbid patients To help Chronic Obstructive Pulmonary Disease (COPD) patients with comorbidities and to reduce the burden on our health systems, the WELCOME project aims to create innovative solutions such as an integrated care management tool and a ...
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 FINISHED 
Worldwide figures show that there were 160,000 incidences of melanoma in 2002, whilst 39,000 died from the disease. These upward trends are worrying, as malignant melanoma is one of the most difficult cancers to treat, due to its ability to spread quickly and its resistance to standard chemotherapeutic agents. In order to counteract this trend, targeted therapies that inhibit melanoma metastasis a ...
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 FINISHED 

EPISCHOOL – pokonajmy bariery razem!

Start date: 01 Oct 2015, End date: 30 Sep 2017,

The aim of the Project is to bring up a serious problem - epilepsy among children and teenagers at school. This problem touches not only persons with the disease, but also their teachers who not always are aware of the seriousness of the problem and are competent enough to cope with it. There are many examples of mistreating sick persons, such as forcing them to change school etc. By initializing ...
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 4

 FINISHED 

Higher education student and staff mobility project

Start date: 01 Jun 2016, End date: 30 Sep 2017,

This is a higher education student and staff mobility project, please consult the website of the organisation to obtain additional details.
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 FINISHED 
Assuming an annual birth rate of 10.25 births/1,000 population approximately 25,000 Extremely Low Gestational Age Newborns are born every year in the EU. Conservative figures estimate that approximately half of all these babies will develop low blood pressure and require treatment. However, no uniform criteria exist to define hypotension and the evidence to support our current management strategie ...
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 FINISHED 
This is a project for higher education student and staff mobility between Programme Countries and Partner Countries. Please consult the website of the organisation to obtain additional details.
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 1

 FINISHED 
This is a project for higher education student and staff mobility between Programme Countries and Partner Countries. Please consult the website of the organisation to obtain additional details.
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 1

 FINISHED 

Organo-Catalytic Nanoparticles for Organic Synthesis (OCN4OS)

Start date: 01 Jun 2015, End date: 31 May 2017,

The objective of this proposal is the development of a platform of recyclable organocatalysts that could be employed in the preparation of drugs or intermediates thereof. In order to achieve this objective the proposal brings together 3 partners with complementary skills: an expert in Phase Transfer Catalysis, Organo-Catalysis and synthesis (RCSI), an expert in development of DNA based catalysis a ...
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 FINISHED 
Adult articular cartilage has a limited capacity for repair so when damaged it can lead to joint degeneration and ultimately osteoarthritis. In our lab we have had significant success in enhancing tissue regeneration by functionalising collagen-based scaffolds for the delivery of therapeutic genes. In this project we propose to apply this concept for the delivery of microRNAs to promote enhanced c ...
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 FINISHED 
Classical pathologic parameters have been used to inform adjuvant clinical treatment choices for early breast cancer patients. There remain a significant number of patients however, who despite a reportedly favourable prognostic profile, experience metastatic disease. Elucidation of the mechanisms of tumour adaptability and the identification of predictive markers of early recurrence is the basis ...
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 2

 FINISHED 

Higher education student and staff mobility project

Start date: 01 Jun 2015, End date: 30 Sep 2016,

This is a higher education student and staff mobility project, please consult the website of the organisation to obtain additional details.
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 1

 FINISHED 

Clinical Officer Surgical Training in Africa (COST - Africa)

Start date: 01 Apr 2011, End date: 30 Sep 2016,

Obstetrical and abdominal emergencies, and trauma, much of it affecting children, represent a major and neglected part of Africa’s burden of disease. Countries cannot train and retain sufficient specialist surgeons (doctors) to address these priorities. We propose a surgical training intervention targeted at Clinical officers (COs), who are trained non-physician clinicians that form the backbone o ...
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 FINISHED 
Evidence is emerging that rapid, profound and persisting changes in gene expression regulation and post-transcriptional regulation underlies the epileptogenic process. The current proposal builds on preliminary data which demonstrates that rapid reduction of a microRNA; miR-124, causes increased expression and activity of NRSF, a master-regulator of epileptogenesis. The current proposal will buil ...
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 FINISHED 
In recent years the treatment paradigm for metastatic colorectal cancer (mCRC) has evolved in complexity to include newly developed targeted therapeutics. In 2004 bevacizumab (bvz) [Avastin] became the first anti-angiogenic drug to be licensed in malignant disease, based on the results of a randomised trial in advanced metastatic colorectal cancer. Nevertheless, over the past six year period emerg ...
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 12

 FINISHED 

TRANSLATIONAL RESEARCH AND PATIENT SAFETY IN EUROPE (TRANSFoRm)

Start date: 01 Mar 2010, End date: 30 Nov 2015,

TRANSFoRm will develop rigorous, generic methods for the integration of Primary Care clinical and research activities, to support patient safety and clinical research via:1.\tRich capture of clinical data, including symptoms and signs rather than just a single diagnosis. A generic, dynamic interface, integrated with electronic health records (EHR), will facilitate both diagnostic decision support ...
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