Search for European Projects

31 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Metagenomics in Cardiometabolic Diseases (METACARDIS)

Start date: Nov 1, 2012, End date: Oct 31, 2018,

METACARDIS applies a systems medicine multilevel approach to identify biological relationships between gut microbiota, assessed by metagenomics, and host genome expression regulation, which will improve understanding and innovative care of cardiometabolic diseases (CMD) and their comorbidities. CMD comprise metabolic (obesity, diabetes) and heart diseases characterized by a chronic evolution in ag ...
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 18

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Non-coding RNAs in neurogenic and neuropathic pain mechanisms and their application for risk assessment, patient stratification and personalised pain medicine (NCRNAPAIN)

Start date: Oct 1, 2013, End date: Sep 30, 2017,

Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs (ncRNAs) regulate both immune and neuronal processes. Therefore, ncRNAPain proposes that ncRNAs are critically important master switches for chronic pain.ncRNAPain represents a multidisciplinary consortium of clinical partners, molecular and systems-level n ...
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 12

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eNanoMapper - A Database and Ontology Framework for Nanomaterials Design and Safety Assessment (ENANOMAPPER)

Start date: Feb 1, 2014, End date: Jan 31, 2017,

eNanoMapper will develop a data management and analysis infrastructure together with ontologies supporting the safety assessment activities of the European Nanomaterials research and development community. The project will address the requirements of safety assessment of nanomaterials by providing databases, analysis tools and ontologies for risk assessment and linking them with existing resources ...
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 11

 FINISHED 

A European Platform for Translational Cancer Research (EUROCANPLATFORM)

Start date: Jan 1, 2011, End date: Dec 31, 2016,

Europe has a number of advantages as regards developing translational cancer research, yet there is no clear European strategy to meet the increasing burden posed by cancer. The FP6 Eurocan+Plus project analysed the barriers underlying the increasing fragmentation of cancer research and stressed the need to improve collaboration between basic/preclinical and comprehensive cancer centres (CCCs), in ...
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 29

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European Medicines Research Training Network (EMTRAIN)

Start date: Oct 1, 2009, End date: Sep 30, 2016,

EMTRAIN is an essential element for the success of the IMI Education & Training (E&T) Call Topics in Europe (current and future). It will establish a pan-European platform of excellence for education and training covering the whole life-cycle of medicines from basic research through clinical development to pharmaco-vigilance. It will underpin the successful delivery of the current and future IMI-f ...
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 32

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Transnational access and enhancement of integrated Biological Structure determination at synchrotron X-ray radiation facilities (BIOSTRUCT-X)

Start date: Sep 1, 2011, End date: Feb 29, 2016,

The BioStruct-X consortium has 19 partners from 11 EU member and associated states, who lead in facility provision and research in structural biology using high brilliance X-rays, provided by state-of-the art synchrotrons and a free electron laser. BioStruct-X will provide integrated transnational access via 42 installations in four key areas: macromolecular X-ray crystallography, small angle X-ra ...
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 20

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Sphingolipid homeostasis: from basic biology to applications (SPHINGONET)

Start date: Feb 1, 2012, End date: Jan 31, 2016,

SPHINGONET was inspired by a common vision of its partners on the training of researchers in the field of sphingolipid homeostasis and body-wide sphingolipid signaling networks using innovative technological approaches. Dysregulation of sphingolipid balances contributes to a broad range of pathological processes, spanning neurodegeneration, asthma, autoimmune disease, insuline resistance, obesity ...
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 10

 FINISHED 

Training Network on Zebrafish Infection Models for Pharmaceutical Screens (FishForPharma)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

Infectious diseases caused by pathogenic micro-organisms are major causes of death, disability, and social and economic disruption for millions of people. During evolution these pathogens have developed intricate strategies to manipulate host defence mechanisms and outwit the immune system. To reduce the burden of infectious diseases it is important to increase understanding of these host-pathogen ...
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 10

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Systems microscopy – a key enabling methodology for next-generation systems biology (Systems Microscopy)

Start date: Jan 1, 2011, End date: Dec 31, 2015,

Biological processes occur in space and time, but current experimental methods for systems biology are limited in their ability to resolve this spatiotemporal complexity of life. In addition, traditional “omics” methods often suffer from limited sensitivity and need to average over populations of cells at the expense of cell to cell variation. Next-generation systems biology therefore requires met ...
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 11

 FINISHED 

"""RNPnet"" - RNP structure, function and mechanism of action" (RNPNET)

Start date: Nov 1, 2011, End date: Oct 31, 2015,

RNA molecules are at the heart of life. It is now commonly admitted that nearly all the human genome is transcribed, and a wealth of new coding and non-coding RNAs have been discovered. Importantly, modern RNAs are never naked, but always exist in complex with proteins to form RNPs (Ribonucleoproteins). In the case of non-coding RNAs, these proteins are usually stably associated with the RNA and h ...
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 15

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EUCOMM: Tools for Functional Annotation of the Mouse Genome (EUCOMMTOOLS)

Start date: Oct 1, 2010, End date: Sep 30, 2015,

The EUCOMMTOOLS Collaborative Project responds to the topic ‘HEALTH.2010.2.1.1-1: Large-scale efforts in mouse functional genomics to determine the functions of genes and their involvement in disease.’ EUCOMMTOOLS will provide, in a systematic high-throughput way, genetic tools and resources contributing to the determination of every gene’s function in any cell type of the entire organism at any g ...
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 11

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Systems Biology of Mitosis (MitoSys)

Start date: Jun 1, 2010, End date: May 31, 2015,

"MitoSys will generate a comprehensive mathematical understanding of mitotic division in human cells, a process of fundamental importance for human health. To create the critical mass and multidisciplinarity that is needed to achieve this ambitious goal, internationally leading mathematicians, biochemists/biophysicists and biologists working at twelve universities, research institutes, internation ...
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 14

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Towards the establishment of a permanent European Virtual Institute dedicated to Malaria Research (EVIMalaR) (EVIMalaR)

Start date: Oct 1, 2009, End date: Mar 31, 2015,

This is a proposal from 55 partners from 36 institutes to form a NoE that will seek to integrate European malaria research that is directed towards a better understanding of the basic biology of the parasite, its vector and of the biology of the interactions between the parasite and both its mammalian host and vectors. All the member institutes and researchers have demonstrated both their excellen ...
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 40

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International Human Microbiome Standards (IHMS)

Start date: Feb 1, 2011, End date: Jan 31, 2015,

A detailed understanding of human biology will require characterisation of the human-associated microorganisms, the human microbiome, and of the roles these microbes play in health and disease. Large projects in Europe, the United States, China and Canada target these objectives, using high throughput –omics approaches. Given the complexity of our microbial communities, composed of thousands of ...
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 8

 FINISHED 

High resolution tools to understand the functional role of protein intrinsic disorder (IDPBYNMR)

Start date: Nov 1, 2010, End date: Oct 31, 2014,

Recent evidence shows that a large share of proteins gain functional advantages by remaining natively unstructured, either completely or partially, thus challenging well-established concepts in structural biology. In order to characterize the highly dynamical nature of such “intrinsically disordered proteins”, and follow their (possible) reorganization by interacting with partners, new integrated ...
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 10

 FINISHED 

Communication of European Health Research (COMMHERE)

Start date: Oct 1, 2011, End date: Sep 30, 2014,

The overall aim of CommHERE is to improve communication on the outcome of EU funded health research projects to the media, the general public and other target groups including the EC in all of Europe.The CommHERE consortium comprises 10 partners, all research institutions active in the health research area. All partners are responsible for the coordination of EU-funded health research projects. Th ...
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 12

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A worldwide e-Infrastructure for NMR and structural biology (WeNMR)

Start date: Nov 1, 2010, End date: Oct 31, 2013,

Structural biology and life sciences in general, and NMR in particular, have always been associated with advanced computing. The current challenges in the post-genomic era, with their focus on biomolecular interactions, call for virtual research platforms that provide the worldwide research community with both user-friendly tools, platforms for data analysis and exchange, and an underlying e-infra ...
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 9

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Nucleosome Structure & Function across Biological Scales and Biological Function (NUCLEOSOME4D)

Start date: Nov 1, 2009, End date: Oct 31, 2013,

Chromatin packages a few meters of DNA into a nucleus measuring a few microns. This tight folding occurs by assembling DNA with histones into so-called nucleosomes, thus ensuring the mechanical stability of our genome. On the flipside, this makes nucleosomes a formidable obstacle to the machines that read, copy or repair its DNA message. One of the fundamental questions in biology is to understand ...
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 17

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“The International Data Coordination Centre” (I-DCC)

Start date: Jan 1, 2009, End date: Sep 30, 2013,

"The I-DCC coordination and support project responds to the topic defined by HEALTH-2007-2.1.2-6 “International activities in large-scale data gathering and systems biology”. I-DCC integrates European skills, efforts, resources, and infrastructure in an international collaborative programme to establish a European Data Coordination Centre for mouse genetic resources. Large-scale mouse mutagenesis ...
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 10

 FINISHED 

Assessment of the regulatory mechanisms of different protein post-translational modifications by studying their role within a realistic in silico model of the cell (InToAct)

Start date: Sep 1, 2011, End date: Aug 31, 2013,

The cell can be seen as an intricate network of molecular relationships that determines its potential activities. The study of the composition of such a complex network including not only the description of their elements but also the structure of their relationships, i.e. its topology, was previously used to extract important elements (e.g. hubs proteins) and to find recurrent circuits that chara ...
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 1

 FINISHED 

Light-based functional in vivo monitoring of diseases related enzymes (LIVIMODE)

Start date: Nov 1, 2009, End date: Apr 30, 2013,

"LIVIMODE aims to develop specific tools for non invasive in vivo imaging of disease related molecular events. Such tools are of high relevance for disease detection, staging, developing animal models of human disease, and evaluating novel therapies. We propose to use optical imaging, which is optimally suited for this task as it provides excellent sensitivity and allows visualizing molecular even ...
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 13

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Evolution of gene regulatory networks in animal development (EVONET)

Start date: Oct 1, 2008, End date: Sep 30, 2012,

"Genetic and mutant analyses in Drosophila and other standard model organisms have revealed hierarchical gene networks and identified some key regulatory genes acting in animal development. While surprising conservation exists on a broad scale between distant phyla, significant differences have also been detected. Systems biology approaches in the main model systems have now revealed more complex ...
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 7

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"An integrated study on three novel regulatory hubs in megakaryocytes and platelets, discovered as risk genes for myocardial infarction by a genome-wide association and platelet systems biology study" (NETSIM)

Start date: Sep 1, 2008, End date: Aug 31, 2012,

"The overarching objective of the ITN is to offer an intercalated study environment for young and talented researchers in the field of coronary artery disease (CAD) research. 12 PhD fellows operating in a unique training environment will work as a multi-disciplinary team to perform research spanning the full spectrum from basic to translational to bring novel inventions to the bedside. The fello ...
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 10

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Cis-regulatory logic of the transcriptional control in neural stem cells (CISSTEM)

Start date: Oct 1, 2008, End date: Mar 31, 2012,

"Neural stem cells (NSCs) have emerged as a major topic in neurobiology. The persistence of multipotent cells in the adult mammalian brain offers a realistic chance for the treatment of neurodegenerative diseases. It is thus crucial to understand NSCs from as many as possible angles (e. g. cellular and molecular biology), in order to better isolate and successfully manipulate them. CISSTEM present ...
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 9

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Cross-talk of cell metabolism and post-transcriptional control via RNA-binding enzymes? (CoREMEn)

Start date: Apr 1, 2010, End date: Mar 31, 2012,

The role of metabolic enzymes in the post-transcriptional control of gene expression is barely explored, with only a few cases deeply studied so far, such as aconitase 1 in iron metabolism or GAIT complex control of pro-inflammatory genes. Here, we propose to identify metabolic enzymes that interact specifically with mRNA by unbiased proteomic and transcriptomic approaches and to investigate their ...
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 1

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In-vitro system for mammalian miRNA function (miRNA mechanism)

Start date: Apr 1, 2010, End date: Mar 31, 2012,

Over the past decade, micro (mi) RNAs have emerged as key regulators of gene expression. Many miRNAs have been linked to diseases, such as cancer or diabetes. MiRNAs bind to specific sequences in the 3’-untranslated region (UTR) of mRNAs, thereby causing inhibition of translation and/or mRNA degradation. However, the detailed molecular mechanism and the factors involved in miRNA-mediated gene sile ...
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 1

 FINISHED 

Quantitative dynamic analysis of homologous chromosome segregation and its coordination with the asymmetric meiotic division in live mouse oocytes (Oocyte Asymmetry)

Start date: Apr 1, 2010, End date: Mar 31, 2012,

Cell division is a fundamental biological process: faithful chromosome segregation is important to maintain genome stability. The first meiotic division is a unique type of chromosome segregation for two main reasons. First, it segregates homologous chromosome pairs rather than sister chromatids, as it occurs in mitosis. Second, the chromosomes are segregated only when the meiotic spindle has been ...
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 1

 FINISHED 

Mapping the Cell

Start date: Mar 1, 2009, End date: Feb 29, 2012,

A key challenge of systems biology is to understand how genes function as networks to carry out and regulate cellular process. Many important insights have emerged in recent years from studies using the yeast Saccharomyces cerevisiae. A partial genetic-interaction network has been compiled using double knockout mutations. Analysis of this network has provided many important insights about gene fun ...
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 1

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New Approaches to Target Tuberculosis (NATT)

Start date: Oct 1, 2008, End date: Sep 30, 2011,

"The increasing emergence of multidrug resistant strains and extensively drug resistant strains, the last one being virtually untreatable, urgently demand novel drugs for therapy of tuberculosis. This project has the aim of bringing together a number of research scientists with expertise in a broad range of disciplines, both from Europe and from India, covering the development field from chemistry ...
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 8

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European Light Sources Activities - Synchrotrons and Free Electron Lasers (ELISA)

Start date: Mar 1, 2009, End date: Aug 31, 2011,

"Europe has the largest and most advanced system of synchrotrons and free electron lasers (FELs): 17 operating facilities, several under construction, some 300 beamlines, 25,000-30,000 users per year from many disciplines (materials, chemistry, biology, medicine, physics, technology and others); this is also the world’s largest experimental network. The system is an open resource for all scientist ...
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 17

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Mechanism of cellular IRESes translation (Cellular IRESes)

Start date: Aug 1, 2009, End date: Jul 31, 2011,

The central importance of translation control in cancer is just beginning to be fully appreciated. Translation normally initiates with the recruitment of the initiation factors to the 5’ cap of the mRNA for ribosome binding. Curiously, some normally capped cellular messages, which are involved in cell-cycle control, growth and apoptosis, rely alternatively on an internal ribosome entry site (IRES) ...
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 1