Search for European Projects

Over 40 European Projects Found

Searched on 125080 European Projects

 ONGOING 
Abstract 9Neuroimaging (NI) has enormous potential to improve the clinical care of patients with psychiatric disorders, but has yet to deliver. The PSYSCAN project will address this issue directly by developing a NI-based tool that will help clinicians resolve key clinical issues in the management of patients with psychotic disorders. Clinicians will use the tool to assess patients with a standard ...
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 ONGOING 

The Developing Human Connectome Project (dHCP)

Start date: Sep 1, 2013, End date: Aug 31, 2019,

Few advances in neuroscience could have as much impact as a precise global description of human brain connectivity and its variability. Understanding this ‘connectome’ in detail will provide insights into fundamental neural processes and intractable neuropsychiatric diseases.The connectome can be studied at millimetre scale in humans by neuroimaging, particularly diffusion and functional connectiv ...
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 ONGOING 
"Population ageing and the transition from infectious to chronic diseases is occurring more rapidly in middle than it did in high income countries. Chronic diseases are already leading causes of death in all regions, but the focus on preventing premature mortality neglects the societal impact of the emerging epidemic on disability/dependence, particularly in older people. The PIs 12 year program o ...
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 FINISHED 
Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behavior is seen. This calls for a shift to new approaches. By capitalising on comprehensive longitudinal cohorts, recent advances in genetic, biological, epidemiological, a ...
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 FINISHED 
Ego-media: The impact of new media on forms and practices of self-presentationThis project aims to study the impact of new media on autobiographical narratives: an impact increasing as habits and practices of self-presentation evolve rapidly in response to constantly fast-changing technology. It will analyse the range of ways in which autobiographical forms and discursive practices are being trans ...
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 FINISHED 
Conduct Disorder (CD) is the key paediatric disorder characterized by severe aggression. It is heterogeneous, and our understanding of the neurobiology to subtype aggression is limited. MATRICS is a multidisciplinary consortium of academic partners and SMEs that focuses on the subtyping of aggression both within CD and of the broader cross-disorder trait of aggression. MATRICS will test the hypoth ...
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 FINISHED 

Nodal Lines (NODAL)

Start date: Feb 1, 2014, End date: Jan 31, 2019,

"First observed by the physicist and musician Ernst Chladni in the 18th century, the nodal lines(also referred to as the Chladni Plates or Chladni Modes) appear in many problems in engineering, physics and natural sciences. Nodal lines describe sets that remain stationary during membrane vibrations, hence their importance in such diverse areas as musical instruments industry, mechanical structures ...
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 FINISHED 
The overall aim of this project is to identify key biophysical mechanisms that control the spatial arrangement of signalling proteins and membrane lipids in the regulation of T cell activation. During an immune response, T cells are activated in response to antigenic peptides in a process that requires the formation of multi-molecular signalling complexes. It is known that many T cell signalling p ...
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 FINISHED 
Transition to adulthood is the period of onset of most of the serious mental disorders that disable or kill in adult life. Current service configuration of distinct Child and Adolescent Mental Health (CAMHS) and Adult Mental Health (AMHS) Services is considered the weakest link where the care pathway should be most robust. Transition-related discontinuity of care is a major socioeconomic and socie ...
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 14

 FINISHED 
VOX-Pol is a 60-month, €5+ million project that integrates the world’s leading researchers and research groups in Violent Online Political Extremism (VOPE), to include those researching the intersection of terrorism and the Internet (incl. violent jihadists, violent separatists, etc.), the online activities of the extreme Right, the potential for violent online radicalisation, etc., in order to:1. ...
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 FINISHED 
The aim of the SOURCE Network of Excellence is to create a robust and sustainable virtual centre of excellence capable of exploring and advancing societal issues in security research and development. The SOURCE Network of Excellence is built upon five types of activities: networking activities, research, information gathering, education and training, and knowledge-sharing. These five areas togethe ...
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 14

 FINISHED 
APPLAUSE’s aim is to produce a body of evidence that illustrates how young people with mental health problems currently interact with both formal mental health services and informal social and familial support structures. Careful analysis of data gathered in the UK and Brazil will allow formulation of globally relevant insights into mental health care delivery for young people, which will be prese ...
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 FINISHED 
Changes in input lead to changes of synaptic circuits in the brain via a combination of synapse specific Hebbian plasticity and cell-wide homeostatic plasticity. While Hebbian plasticity has been well studied, there are still a number of outstanding fundamental questions related to homeostatic plasticity. We have previously developed a paradigm that allows us to monitor changes to multiple homeost ...
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 FINISHED 
"We want to determine how oxidants are sensed and transduced into a biological effect within the cardiovascular system. The proposed work will focus on thiol-based redox sensors, defining their role in heart and blood vessel function during health and disease. Although this laboratory has studied the molecular basis of redox signaling for more than a decade, the subject is still in its relative in ...
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 FINISHED 

Complex Synthetic Mimics of the Cell Membrane (COSMIC)

Start date: Feb 1, 2013, End date: Oct 31, 2018,

I propose to bridge the gap between simple in vitro measurements of biological processes, and the complexities of the cellular environment. This requires reduced in vitro systems that are sufficiently complex to reproduce the subtleties of the in vivo biological phenomenon, but sufficiently controllable to test how quantitative changes in a particular property affects function. The challenge is to ...
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 2

 FINISHED 
Aggression is a basic physiological trait with important roles throughout evolution, both in defence and predation. When expressed in humans in the wrong context, aggression leads to maladjustment, social impairment and crime. Despite this, knowledge about aggression aetiology is limited and current treatment strategies are insufficient. Contingent to a subdivision into impulsive and instrumental ...
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 27

 FINISHED 
DESIRE will focus on epileptogenic developmental disorders EDD, i.e. early onset epilepsies whose origin is closely related to developmental brain processes. A major cause of EDD are malformations of cortical development (MCD), either macroscopic or subtle. EDD are often manifested as epileptic encephalopathies (EE), i.e. conditions in which epileptic activity itself may contribute to severe cogni ...
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 FINISHED 

Hepatic and Cardiac Toxicity Systems modelling (HECATOS)

Start date: Oct 1, 2013, End date: Sep 30, 2018,

HeCaToS aims at developing integrative in silico tools for predicting human liver and heart toxicity. The objective is to develop an integrated modeling framework, by combining advances in computational chemistry and systems toxicology, for modelling toxic perturbations in liver and heart across multiple scales. This framework will include vertical integrations of representations from drug(metabol ...
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 14

 FINISHED 
Assessing individual exposure to environmental stressors and predicting health outcomes implies that both environmental exposures and epi/genetic variations are reliably measured simultaneously. HEALS (Health and Environment-wide Associations based on Large population Surveys) brings together in an innovative approach a comprehensive array of novel technologies, data analysis and modeling tools th ...
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 FINISHED 
"Pain-OMICS is a multidisciplinary consortium of leading clinical, academic and SME researchers in pain and different omics technologies. Genome-wide association studies identified a number of loci associated with pain, but the level of knowledge about underlying mechanisms of different pain syndromes as well as individual variation in the disease course remains inadequate. Pain-OMICS will capital ...
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 11

 FINISHED 
The therapeutic vaccination against breast cancer, and more widely all solid tumours, has largely been ineffective in clinical trials. This failure has been attributed to ‘immune editing’ of the cancerous cells, or to suppression of T cell functions within the tumour. In relation to the later, we have identified a novel population of tumoural macrophages, marked by the expression of fibroblast act ...
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 FINISHED 
This project investigates the cross-fertilisation of Anglo/American and German literature and film during the Allied Occupation of Germany. It will be the first study to survey the cultural landscape of the British and American zones of Occupied Germany in any detail. By doing so it will offer a new interpretative framework for postwar culture, in particular in three areas: the history of the Alli ...
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 1

 FINISHED 

Evaluation Practices in Financial Markets (EPIFM)

Start date: Sep 1, 2012, End date: Aug 31, 2018,

EPIFM will be a social-science (rather than, as conventionally, an economic) investigation, by a team bridging science and technology studies (STS), sociology and politics, of how professional participants in financial markets evaluate financial instruments such as shares and bonds. These evaluation practices are crucial to the operation of financial markets (they help determine the activities to ...
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 FINISHED 
"The movement of Africans and Europeans to the Americas through expansionism, colonialism, and slavery also brought to the New World African percussive rhythms and European musical instruments and courtly dances. This project investigates the social dances that evolved out of this encounter, and retained African rhythm structures and body movement in American and Caribbean diasporic spaces. Under ...
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 1

 FINISHED 

Music in London, 1800-1851 (Muslond)

Start date: May 1, 2013, End date: Apr 30, 2018,

This project aims to construct a wide-ranging interdisciplinary history of music in London in the first half of the nineteenth century. It will be original in method and scope, will generate a series of book-length publications, and is intended to serve as a model for a new kind of music historiography. Past histories of Western music-making have mostly focussed on elite culture, and have tended t ...
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 FINISHED 
Self-assembly is a hallmark of Biology. We are far from a complete understanding of this natural assembly, which in turn limits our ability to mimic biological construction in the bioengineering of tuneable synthetic systems.This proposal addresses the major challenge of membrane protein folding. Here, I intend to make a step change to my pioneering biophysical studies and investigate co-translati ...
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 2

 FINISHED 
Photonic methamaterials have unique optical properties not available in natural materials. The key question is how to integrate metamaterials within nanophotonics circuitry to harness all the advantages they offer in controlling light on the nanoscale. iPLANET will develop a plasmonic nanorod metamaterial platform for applications covering the entire spectral range from mid-IR through telecom to v ...
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 FINISHED 

Mechanisms Underlying Treatment Responses in Psychosis (MUTRIPS)

Start date: Mar 1, 2013, End date: Feb 28, 2018,

"Psychotic symptoms (hallucinations and delusions) have been associated with a striatal hyperdopaminergic state.Less explored, but also implicated are functional abnormalities in cognitive control, particularly in the prefrontal cortex; and a functional and structural disconnectivity between this and other areas of the brain.Such a disconnectivity would explain the lack of coherent response to con ...
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 FINISHED 
"Mental disorders affect 38.2% of the EU population. For reducing the associated burden, countries across Europe engage in costly re-organizations of mental health care systems. Reforms focus on one controversial core question: Should systems be functional or integrated? In functional systems, separate staff in different services are in charge of in- and out-patient care (to enhance specialization ...
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 FINISHED 

Clearing Clutter Bit by Bit (SQUIRREL)

Start date: Feb 1, 2014, End date: Jan 31, 2018,

Clutter in an open world is a challenge for many aspects of robotic systems, especially for autonomous robots deployed in unstructured domestic settings, affecting navigation, manipulation, vision, human robot interaction and planning.SQUIRREL addresses these issues by actively controlling clutter and incrementally learning to extend the robot's capabilities while doing so. We term this the B3 (bi ...
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 10

 FINISHED 

European Medical Information Framework (EMIF)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

In response to the need to tackle increasingly complex medical research questions, a growing amount of human health data is being collected, either in routine Electronic Healthcare Record (EHR) databases, through research-driven cohort studies, in biobanks or related efforts. However, data sources are typically fragmented and contain information gaps which prevent their full exploitation. EMIF aim ...
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 FINISHED 
"Neuronal circuitries underlying the function of the mammalian cerebral cortex collectively constitute one of the most complex biological systems. As such, unraveling the mechanisms that control their development represents one of the most challenging questions in Science. Understanding this process is also an imperative need in biomedicine, because abnormal wiring is thought to cause severe neuro ...
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 FINISHED 
RDEB is one of the most severe rare genetic skin diseases of children and adults characterized by skin blistering resulting from lack of expression of type VII collagen. There is no treatment for this life-threatening disease. In March 2009, we obtained the orphan drug designation for the Medicinal product: “Skin equivalent graft genetically corrected with a COL7A1-encoding SIN retroviral vecto ...
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 10

 FINISHED 

The Gauge/Gravity Duality and Geometry in String Theory (Gauge/Gravity)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

While the three sub-atomic forces are described by quantum mechanics, the fourth known force, gravity, is described by Einstein's theory of general relativity. These two very successful theories are incompatible, and understanding how to unify them in a single framework is an outstanding problem. String theory is the most prominent candidate for a unified theory of all forces of Nature. The most i ...
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 FINISHED 

Preparing for Extreme And Rare events in coastaL regions (PEARL)

Start date: Jan 1, 2014, End date: Dec 31, 2017,

"Coastal floods are one of the most dangerous and harmful natural hazards affecting urban areas adjacent to shorelines. Rapid urbanisation combined with climate change and poor governance means a significant increase in the risk of local surface flooding coinciding with high water levels in rivers and high tide or storm surges from the sea, posing a greater risk of devastation to coastal communiti ...
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 FINISHED 
"Advances in numerical methods and three-dimensional imaging techniques have enabled the quantification of cardiovascular mechanics in subject-specific anatomic and physiologic models. Research efforts have been focused mainly on three areas: pathogenesis of vascular disease, development of medical devices, and virtual surgical planning. However, despite great initial promise, the actual use of pa ...
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 FINISHED 
HIV/AIDS, Tuberculosis (TB) and Malaria alone account for more than six million deaths worldwide every year. Despite substantial efforts made in recent years, Poverty Related Diseases are still spreading. New therapeutic interventions are therefore urgently required to combat Poverty Related Diseases. The existence of a well-developed HIV/TB/Malaria infrastructure presents a prime opportunity to a ...
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 FINISHED 
The objective of the EMERALD Project is to improve mental health outcomes by enhancing health system performance.The key issues addressed are: (i) adequate, fair & sustainable resourcing: using human, infrastructural, informational & financial resource inputs to effectively deliver better mental health services; (ii) integrated service provision: enhancing access to integrated community care; and ...
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 FINISHED 
Organ transplantation has emerged as the “gold standard” therapy for end-stage organ failure. Incomplete control of chronic allograft injury but also the adverse effects of long-term immunosuppression (IS) continue to challenge the long-term success of transplantation. The paradigm is shifting from increasing “net”-IS by novel drugs to the concept of minimizing long-term IS as early as possible. H ...
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 FINISHED 
Stroke disables millions worldwide and costs the EU €38 billion each year. Excitingly, my team has identified a clinically-feasible therapy for stroke which reverses disability in rats when given in a clinically-relevant time frame. Specifically, we have shown that the human growth factor neurotrophin 3 (NT3) promotes locomotor recovery and reverses sensory neglect in adult rats when infused into ...
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