Search for European Projects

19 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Combatting Bacterial Resistance in Europe (COMBACTE-NET)

Start date: Jan 1, 2013, End date: Dec 31, 2019,

The emergence of Antibiotic-resistant bacteria (ARB) is a global problem, having recently been elevated to the top three threats identified by the World Health Organisation (WHO), and subject of numerous national and international government activities, including the Trans-Atlantic Task Force on Antimicrobial Resistance established by the US and EU presidencies. The estimated costs of ARB are aro ...
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 38

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Although vaccination is the cornerstone of prophylaxis, current vaccines provide only moderate protection. Most employ inactivated or protein-based, including multimeric antigen, vaccines requiring annual updating. Their limited antigen loads provide limited capacity for inducing robust immune defences, without assurance that both humoral and cell mediated (CMI) responses, as well as durable immun ...
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 11

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Most biopharmaceuticals (BP) currently on the market are recombinant proteins which are parenterally administered. These would benefit from more patient-friendly routes of administration. Moreover, new classes of BP (e.g. siRNA, miRNA, DARPins) with specificity for intracellular targets hold promise but await the advent of efficient delivery systems before their potential can be realised into ther ...
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 22

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"Actinomycetes produce a wealth of important natural products, which play a pivotal role in modern drug-based therapy of various diseases. Recent whole-genome sequencing projects have revealed that the number of biosynthetic gene clusters significantly outnumbers the natural products produced by actinomycetes under laboratory conditions. Only a minority of biosynthetic gene clusters are expressed ...
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 1

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The mouse shows great similarities in development, physiology and biochemistry to humans, which makes it a key model for research into human disease. The major challenges for mouse functional genomics in the 21st century are to:• Develop a series of mutant alleles for every gene in the mouse genome• Determine the phenotypic consequences of each mutation• Identify mouse models for the complete dise ...
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 24

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European Medicines Research Training Network (EMTRAIN)

Start date: Oct 1, 2009, End date: Sep 30, 2016,

EMTRAIN is an essential element for the success of the IMI Education & Training (E&T) Call Topics in Europe (current and future). It will establish a pan-European platform of excellence for education and training covering the whole life-cycle of medicines from basic research through clinical development to pharmaco-vigilance. It will underpin the successful delivery of the current and future IMI-f ...
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 32

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International trade is increasing tremendously in recent years with a lot of import and export material going in and out of the European Union. Within this context there is also the increasing risk of importing unwanted organisms via this trade. Organisms include plant pests and pathogens, some of which may be on the quarantine list of the European Union. Also climate change may increase the abili ...
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 17

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"Group AStreptococcus (GAS) is a predominant Gram-positive bacterium causing a substantial burden of diseases in humans. Autophagy is a starvation-induced response that provides nutrients by degrading long-living proteins and recycling intracellular organelles. In 2004, autophagy was identified as a new immune mechanism for killing and clearing invading GAS in epithelial cells. It is regulated by ...
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 1

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"MAGICPAH aims to explore, understand and exploit the catalytic activities of microbial communities involved in the degradation of persistent PAHs. It will integrate (meta-) genomic studies with in-situ activity assessment based on stable isotope probing particularly in complex matrices of different terrestrial and marine environments. PAH degradation under various conditions of bioavailability wi ...
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 15

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This proposal aims to develop and implement efficacy of clinical trials with adult, tissue stem cells for degenerative diseases of epithelia and skeletal muscle. Extraordinary progress in the understanding of several key features of stem cells has been rapidly translated into novel cell therapy protocols that have yielded positive results in pre-clinical models of genetic and acquired diseases and ...
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 20

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The exponential increase in microbial genome and metagenome sequencing throughput has widened the gap between sequence and functional understanding. A clear picture of metabolic processes across the spectrum of bacterial species is essential to enable the exploitation of microbial genomics for the purposes of environmental biotechnology. The Microme project endeavors to extend the scope of microbi ...
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 16

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Medically related Life Sciences use the mouse as a model system to understand the molecular basis of health and disease in humans (>95% similarity of genes in humans and mice). An essential task for Biomedical Sciences in the 21st century will be the functional analysis of mouse models for every gene in the mammalian genome. The major bottlenecks identified by the user community will be proper ...
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 29

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"Persistent infections such as HIV, tuberculosis´(TB) in humans and para-tuberculosis (ParaTB)-, mycoplasma- and Haemophilus-infections in farm animals are global health problems of immense social and economic importance . HIV-1 affects about 40 million people and M. tuberculosis infection is even higher world-wide. Co-infection with M. tuberculosis is estimated in about one-third of HIV-1 infecte ...
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 12

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BACSIN is a 16-member consortium with the main focus to improve rational exploitation of the catalytic properties of bacteria for the treatment and prevention of environmental pollution. Current application of bacteria in the environment is hindered by the lack of knowledge on the effects of stresses on cellular activity, most importantly abiotic stresses prevailing on site (e.g., desiccation or n ...
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 16

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"The diseases caused by Streptococcus pneumoniae are a major public health problem all over the world. Children, elderly people and immuno-compromised individuals are the high-risk targets for pneumococcal diseases. In spite of the availability of a large number of antibiotics the mortality and morbidity due to S. pneumoniae infections remain very high. There are two reasons for this: Firstly, the ...
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 13

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Tuberculosis (TB) continues being a leading cause of death due to a single infectious disease agent. The HIV/AIDS pandemic and the emergence of drug resistance are compounding factors that hinder the control of the disease. Associated with this problem is the emergence of multidrug-resistant (MDR) strains of Mycobacterium tuberculosis, defined as strains resistant to at least isoniazid and rifampi ...
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 8

 FINISHED 

ANTAGONISTS OF PROTEIN-PROTEIN INTERACTIONS (APPI)

Start date: Mar 15, 2008, End date: Mar 14, 2011,

"Dysregulation of cytokine gene expression and cytokine regulated gene expression is the root cause of many diseases including viral and bacterial infections and chronic inflammation. In recent years, a variety of molecular biology and biochemistry research tools enabled the study of direct protein-protein interactions among various cytokine receptors and transcription factors which establish, mai ...
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 1

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Efficient translation of research discoveries into industrial application is an essential element to maintain Europe’s competitiveness in the biomedical and health industry. The main bottleneck is the lack and the fragmented nature of essential research infrastructure and know-how, leading to unacceptable delays and/or preventing the development of new innovative medicines. The aim of EATRIS is to ...
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 20

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"The clock is counting down to the next influenza pandemic. Since 1997, the avian influenza virus strain H5N1 has infected over 250 people worldwide with a fatality rate of ~60%, although so far without sustained human-to-human transmission. In view of the very few efficacious drugs against influenza virus infections and the time it takes to develop a matching vaccine, there is an unmet worldwide ...
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 6