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Arrhythmogenic potential of drugs (ARITMO)

Start date: Jan 1, 2010, End date: Jun 30, 2013,

The ability of some compounds to prolong the QT interval of the electrocardiogram and to precipitate Torsade de Pointes (TdP, a potentially fatal arrhythmia) has caused several regulatory interventions, including drug withdrawals. Specific guidelines have been implemented to detect QT liability of new compounds as early as possible. However there is growing evidence that an increase in the QT inte ...
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