5 European Projects Found
Searched on 125080 European Projects
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Multidimensional analysis of signaling during normal hematopoietic differentiation and stress-induced regeneration (Bloody signals)
Start date: Mar 1, 2015, End date: Feb 28, 2019,
Hematopoieic stem cells (HSCs) are characterized by their ability to self-renew and differentiate into cells of all hematopoietic lineages. During steady-state, HSCs are mostly quiescent and responsible for normal hematopoietic differentiation. In cases of stress such as infection or injury, HSCs need to be activated and repair the hematopoeitic system in a regenerative response that involves sync ...
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Thymopoiesis: From Evolutionary Origins to Future Therapies (EvoThyme)
Start date: Jun 1, 2013, End date: May 31, 2018,
The role of the thymus in cell-mediated immunity was discovered about 50 years ago and it has since become apparent that the thymus is the site of T cell development in all extant vertebrates. Although it has been recognized that thymopoiesis can only be fully understood by the analysis of both the thymic epithelial microenvironment and the intrathymic haematopoietic compartment, significant gaps ...
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Dissection of centromeric chromatin and components: A biosynthetic approach (BIOSYNCEN)
Start date: Feb 1, 2013, End date: Jan 31, 2018,
The centromere is one of the most important chromosomal elements. It is required for proper chromosome segregation in mitosis and meiosis and readily recognizable as the primary constriction of mitotic chromosomes. Proper centromere function is essential to ensure genome stability; therefore understanding centromere identity is directly relevant to cancer biology and gene therapy. How centromeres ...
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Polycomb/Trithorax: Functional EpiGenomics Integrators for Metabolic Disease (MetabolicPolycombics)
Start date: Dec 1, 2011, End date: Nov 30, 2016,
The last decade has seen an explosion of research into the epigenetic regulation of cell biology. Indeed, great efforts have been made to elucidate epigenetic regulation in stem cell biology, development, and within the plastic states of cancer. Current estimates place the prevalence of obesity in the range of 300 million to beyond 1 billion by the year 2030. As a critical risk factor for heart di ...
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Dynamics and stability of covalent protein modifications (PROTMOD)
Start date: Sep 1, 2008, End date: Aug 31, 2014,
"One of the major goals of post-genomic biological research is to understand the molecular basis and physiological role of covalent protein modifications. Post-transcriptional modifications can regulate protein interactions and/or stability and thus trigger particular downstream responses. A major challenge is to understand how modifications of histone proteins are translated into changes in gene ...
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