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Structural analysis of the conformational transitions of the K18 fragment of human tau driven by Hsp70 action (HSP70-TAU NMR)
Start date: May 1, 2014, End date: Apr 30, 2016,
The proteins Tau and α-synuclein are causative agents of several neurodegenerative diseases including Alzheimer’s and Parkinson’s disease. In physiological conditions these neurotoxic proteins adopt a disordered conformation but undergo conformational transitions leading to their aggregation and amyloid fibril formation under neuronal stress. ATP-driven molecular chaperones of the heat-shock prote ...
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