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"During development, neuronal connectivity is initially established by genetically determined intrinsic factors, e.g. molecular cues and spontaneous activity, generating networks according to a ""best guess"" strategy. However, with the appearance of sensory organs, external inputs will refine these connections, allowing adaptation to the environment. In the Xenopus developing visual system, repe ...

The cortex has been described to display synaptic plasticity, which is determinant for the function of cortical microcircuits. Although there is a large literature on neocortical plasticity, most of the experiments addressed the connections of pyramidal cells located in particular cortical layers, so the majority of intracortical connections are yet unexplored with respect to their plasticity. Mor ...