1 European Projects Found
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Dissecting the roles of the beta-catenin and Tcf genetic programmes during colorectal cancer progression (CRC programme)
Start date: Sep 1, 2008, End date: Aug 31, 2013,
Most colorectal cancers (CRCs) are initiated by activating mutations in components of the Wnt signalling pathway. Physiological Wnt signals are required for the specification and maintenance of the stem and progenitor cell compartments of the intestinal crypts. We demonstrated that early colorectal lesions exhibit a constitutive Wnt target gene programme, which is very similar to that of normal in ...
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