Search for European Projects

20 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Translational Research Network in Prostate Cancer (TransPot)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

The Translational Research Network for Prostate Cancer (TransPot) program adopts an innovative, multidisciplinary approach, providing highly sought-after, effective solutions for incurable prostate cancer (PC).The TransPot scientific objective is to obtain an unmatched depth of molecular, mechanistic and informatics systems-level disease understanding in order to improve the prognosis and treatmen ...
Read Project

 11

 FINISHED 

PRoteome-based assessment of vascular disease for the Establishment of a Translational REsearch plATform (PRETREAT)

Start date: Jan 1, 2016, End date: Dec 31, 2019,

Cardiovascular disease (VD) is the leading cause of mortality and morbidity in Europe and worldwide. The objective of the PRETREAT consortium is to generate a joint SME/academic European preclinical platform for providing services for detection of VD and drug development. This platform will combine the use of urinary and/or blood peptidomics in humans and in preclinical animal models of VD, togeth ...
Read Project

 6

 FINISHED 

Development and disease of the renal tract (RENALTRACT)

Start date: Jun 1, 2015, End date: May 31, 2019,

The renal tract (kidneys, the ureters, bladder) is a complex organ system crucial for maintaining the body homeostasis. This organ system arises from different precursor pools through a complex program of patterning, differentiation and morphogenesis in embryonic development. Alteration of this program leads to renal tract malformations (RTM) that are incompatible with a healthy life. While some o ...
Read Project

 8

 FINISHED 

Heart OMics in AGEing (HOMAGE)

Start date: Feb 1, 2013, End date: Jan 31, 2019,

As more people survive into old age, the prevalence of heart failure (HF), one of the most common and debilitating diseases in older people, will rise still further. Delaying or preventing HF will have great benefit to those at personal risk, their families, society and the economy. HOMAGE aims to provide a biomarker (BM) approach that will a) help identify i. patients at high risk of developing ...
Read Project

 22

 FINISHED 

Chromatin Dynamics in Development and Disease (Chromatin3D)

Start date: Jan 1, 2015, End date: Dec 31, 2018,

The cell nucleus is organized and compartmentalized into a highly ordered structure that contains DNA, RNA, chromosomal and histone proteins which make up a structure called chromatin. The dynamics associated with these various components are responsible for regulating physiological processes and the overall stability of the genome. The destabilization of such regulatory mechanisms that act on the ...
Read Project

 12

 FINISHED 

Biomarkers of renal graft injuries in kidney allograft recipients (BIOMARGIN)

Start date: Mar 1, 2013, End date: Feb 28, 2018,

In renal allograft recipients, 10-year graft survival has not improved over the past decades. Histological examination of graft biopsies has long been the gold standard to confirm graft injuries, but biopsies are invasive and histological grading is not very robust. There is thus a need for robust, non-invasive methods to predict and diagnose acute and chronic graft lesions, to improve patient tre ...
Read Project

 13

 FINISHED 

Systems Biology to Identify Molecular Targets for Vascular Disease Treatment (SYSVASC)

Start date: Feb 1, 2014, End date: Jan 31, 2018,

Asymptomatic vascular damage accumulates for years before patients are identified and subjected to therapeutic measures. The limited knowledge on early vascular disease pathophysiology is reflected in the lack of therapeutic options. SysVasc aims to overcome this limitation by mounting a comprehensive systems medicine approach to elucidate pathological mechanisms, which will yield molecular target ...
Read Project

 19

 FINISHED 

Utility of omic-based biomarkers in characterizing older individuals at risk for frailty, its progression to disability and general consequences to health and well-being - The FRAILOMIC Initiative (FRAILOMIC)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

The forecasted increase in the number of older people for this century will be accompanied by an increase of those with disabilities. Disability is usually preceded by a condition named frailty that encompasses changes associated with ageing, life styles and chronic diseases. To detect and intervene on it is of outstanding importance to prevent disability, as recovery from disability is unlikely. ...
Read Project

 29

 FINISHED 

Proteomic prediction and Renin angiotensin aldosterone system Inhibition prevention Of early diabetic nephRopathy In TYpe 2 diabetic patients with normoalbuminuria (PRIORITY)

Start date: Jan 1, 2012, End date: Dec 31, 2017,

Patients with diabetes are at risk of developing diabetic nephropathy, which will ultimately result in the requirement for renal replacement therapy and is also associated with high cardiovascular morbidity and mortality. Detection of low concentrations of albuminuria in urine (microalbuminuria) is the current clinical standard for detecting those at significant risk and targeting preventive treat ...
Read Project

 21

 FINISHED 

European Consortium for High-Throughput Research in Rare Kidney Diseases (EURENOMICS)

Start date: Oct 1, 2012, End date: Sep 30, 2017,

EURenOmics will integrate several established consortia devoted to rare kidney diseases with eminent need and potential for diagnostic and therapeutic progress (i.e. steroid resistant nephrotic syndrome, membranous nephropathy, tubulopathies, complement disorders such a haemolytic uraemic syndrome, and congenital kidney malformations). The Consortium has access to the largest clinical cohorts asse ...
Read Project

 29

 FINISHED 

Clinical and system –omics for the identification of the MOlecular DEterminants of established Chronic Kidney Disease (iMODE-CKD)

Start date: Sep 1, 2013, End date: Aug 31, 2017,

iMODE-CKD integrates multi-disciplinary expertise in proteomics, metabolomics, transcriptomics, bioinformatics, pathology, and clinical science from leading academic and industrial investigators, establishing a unique training platform on biomarker research and Systems Biology. Special emphasis is placed on the application of a wide range of –omics and bioinformatics techniques to clinical researc ...
Read Project

 10

 FINISHED 

Translational research (training) in Polycystic Kidney Disease (TranCYST)

Start date: Dec 1, 2012, End date: Nov 30, 2016,

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is an inherited kidney disorder with a prevalence of more than 1:1000, characterized by the development of renal cysts, slowly progressing towards end-stage renal disease. ADPKD is often associated with extra-renal complications, which can be devastating. Current therapy is directed towards limiting the morbidity and mortality from these complic ...
Read Project

 7

 FINISHED 

The role of Chronic DNA damage in Ageing and Age-related pathology (CodeAge)

Start date: Oct 1, 2012, End date: Sep 30, 2016,

Ageing is an inexorable homeostatic failure of largely unknown aetiology that leads to increased vulnerability to disease limiting the quality of life in the elderly and creating high costs to the society. Until recently, the daunting complexity of the ageing process, the conspicuous lack of tools to study it, and a dearth of experimentally tractable model systems have greatly hindered any hypothe ...
Read Project

 9

 FINISHED 

Molecular Medicine for Bladder Cancer (BCMolMed)

Start date: Oct 1, 2012, End date: Sep 30, 2016,

BCMolMed integrates complementary and multi-disciplinary expertise of two main (research-intensive SME-academia) and five associate partners with the objective to generate a state of the art training platform on application-oriented biomarker research and systems biology. Special emphasis is placed on the efficient employment of proteomics and bioinformatics techniques to clinical research, and un ...
Read Project

 3

 FINISHED 

Translation of novel Biomarkers for Bladder Cancer for clinical outcome prediction (TransBioBC)

Start date: Sep 1, 2013, End date: Aug 31, 2016,

Currently, clinical diagnosis and monitoring of bladder cancer (BC) relies on invasive, highly costly cystoscopy. Additionally, due to high recurrence rates BC treatment is associated with frequent follow-up of patients, making BC one of the most costly types of cancer in terms of management cost. Thus there is a clear clinical need for the development of new approaches for early detection of recu ...
Read Project

 5

 FINISHED 

Markers for Sub-Clinical Cardiovascular Risk Assessemnt (EU-MASCARA)

Start date: Dec 1, 2011, End date: May 31, 2016,

EU-MASCARA is a collaborative project that aims to improve diagnosis of cardiovascular diseases and prediction of cardiovascular risk by analysing a panel of biomarkers. EU-MASCARA aims to examine genetic, proteomic and metabolomic markers together with markers of inflammation, oxidative stress and cardiac remodelling to study their incremental diagnostic and predictive value over and above existi ...
Read Project

 16

 FINISHED 

Systems biology towards novel chronic kidney disease diagnosis and treatment (SysKID)

Start date: Jan 1, 2010, End date: Dec 31, 2014,

Chronic kidney disease (CKD) affects up to 10% of the population. Besides eventual progression towards end stage renal disease CKD impacts the patient’s quality of life by causing serious comorbidities including cardiovascular complications and bone metabolism disorders. On the everyday clinical level early stage diagnosis and tailored treatment of CKD are still inadequate. In addition, CKD seems ...
Read Project

 30

 FINISHED 

IMPROVEMENT OF TOOLS AND PORTABILITY OF MASS SPECTROMETRY-BASED CLINICAL PROTEOMICS AS APPLIED TO CHRONIC KIDNEY DISEASE (PROTOCLIN)

Start date: May 15, 2010, End date: May 14, 2014,

...lasting diabetes and obesity. Early unambiguous detection of patients at risk is both a clinical and scientific challenge. Capillary electrophoresis coupled to mass spectrometry (CE-MS), developed by Mosaiques Diagnostics (MD, SME, Germany), has been shown to be an excellent tool for the discovery and validation of urinary biomarkers of CKD. The aim of this project is to advance CE-MS technology i ...
Read Project

 4

 FINISHED 

Host and viral factors in acute hepatitis C (HEPACUTE)

Start date: Nov 1, 2010, End date: Apr 30, 2014,

Chronic hepatitis C is one of the most common chronic viral infections of humans and a major cause of chronic liver disease, cirrhosis and liver cancer. Still about 4 million new infections occur world-wide each year with 50-85% of patients progressing to chronic hepatitis C. Currently there is no marker to predict spontaneous viral clearance and to guide treatment decisions.The major objectives o ...
Read Project

 17

 FINISHED 

Genomic instability and genomic alterations in pre-cancerous lesions and/or cancer (GENINCA)

Start date: Jan 1, 2008, End date: Jun 30, 2011,

"GENINCA will address two tumor entities, for which we have good access to pre-malignant lesions and in which genomic instability is a common feature: colorectal and liver cancer. Colorectal cancer amounts to 13.2% of all incident cases of cancer, the second most common form of cancer, surpassed only by lung cancer (13.3%). Liver cancer accounts for about 2% of total cancers, however, the most com ...
Read Project

 14