6 European Projects Found
Searched on 125080 European Projects
FINISHED
Metagenomics in Cardiometabolic Diseases (METACARDIS)
Start date: Nov 1, 2012, End date: Oct 31, 2018,
METACARDIS applies a systems medicine multilevel approach to identify biological relationships between gut microbiota, assessed by metagenomics, and host genome expression regulation, which will improve understanding and innovative care of cardiometabolic diseases (CMD) and their comorbidities. CMD comprise metabolic (obesity, diabetes) and heart diseases characterized by a chronic evolution in ag ...
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18
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Bacterial Cell Morphogenesis (BaCeMo)
Start date: Feb 1, 2013, End date: Jan 31, 2018,
In bacteria, the though external cell wall and the intracellular actin-like (MreB) cytoskeleton are major determinants of cell shape. The biosynthetic pathways and chemical composition of the cell wall, a three dimensional polymer network that is one of the most prominent targets for antibiotics, are well understood. However, despite decades of study, little is known about the complex cell wall ul ...
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1
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Environmentally-induced Developmental Origins of Health and Disease (E-DOHAD)
Start date: Feb 1, 2013, End date: Jan 31, 2018,
The DOHaD (Developmental Origins of Health and Disease) hypothesis states that, because of developmental plasticity, in utero and early postnatal stressors can increase chronic disease risk in childhood and later. Alterations of epigenetic marks, impacting on gene expression, are one mechanism that could explain such long-term impact. These hypotheses have so far been tested mostly in animals, and ...
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2
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Simulation of the Kinetics and Inverse Problem for the Protein PolymERization in Amyloid Diseases (Prion, Alzheimer’s) (SKIPPERAD)
Start date: Dec 1, 2012, End date: Nov 30, 2017,
Amyloid diseases are of increasing concern in our aging society. These diseases all involve the aggregation of misfolded proteins, called amyloid, which are specific for each disease (PrP for Prion, Abeta for Alzheimer's). When misfolded these proteins propagate the abnormal configuration and aggregate to others, forming very long polymers also called fibrils. Elucidating the intrinsic mechanisms ...
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2
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Integrated Approaches to Food Allergen and Allergy Risk Management (IFAAM)
Start date: Mar 1, 2013, End date: Feb 28, 2017,
Up to 20 million European citizens suffer from food allergy. However management of both food allergy (by patients and health practitioners) and allergens (by industry) is thwarted by lack of evidence to either prevent food allergy developing or protect adequately those who are already allergic. iFAAM will develop evidence-based approaches and tools for MANAGEMENT of ALLERGENS in FOOD and integrate ...
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46
Partners Participants
FINISHED
Control of Streptococcus agalactiae virulence genes via peptide-based cell to cell communication (CELLCOM-GBS)
Start date: Mar 1, 2013, End date: Feb 28, 2015,
"Quorum sensing (QS) is a bacterial cell-to-cell communication process to control gene expression at population level. Recently, a new QS mechanism was described in streptococci. It involves a transcriptional regulator of the Rgg family and a small hydrophobic peptide (SHP), acting as a signaling molecule. The interaction between SHP and Rgg allows Rgg to control the expression of its target genes ...
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