Archive of European Projects

39 European Projects Found

Searched on 125080 European Projects

 ONGOING 

Boost Brittle Bones Before Birth (BOOSTB4)

Start date: 01 Jan 2016, End date: 31 Dec 2020,

... agnosis to confirm OI before inclusion in the trial. Non-invasive prenatal diagnosis will be developed and validated. The BOOSTB4 consortium is led by experts in MSC, prenatal therapy and OI at the Karolinska Institutet (KI), which will also lead the international multicentre trial; five additional EU centres of excellence are included. Ethical and regulatory applications are underway to conduct t ...
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 13

 FINISHED 
... , Ruxmaniben Deepchand Gardi Medical College (UCTH, India) and initially Sultan Qaboos University (SQU, Oman), Hanoi Medical University (HMU, Vietnam), working with strong European RSDH institutions (Karolinska Institutet KI, Sussex University Institutet for Development Studies IDS and University of Tampere UTA). This region-wide approach will draw skills, resources and students to a new LMICs-bas ...
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 14

 FINISHED 

Higher education student and staff mobility project

Start date: 01 Jun 2014, End date: 31 May 2016,

In the Karolinska Institutet (KI) institutional strategy (Strategy 2020), our Erasmus Policy Statement and our Action Plan for Internationalisation of First Cycle and Second Cycle Education 2014-2017, the importance of internationalisation is stressed. The overall aim of KI is to improve people's health through research and education. Internationalisation, i e all activities bringing an internatio ...
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 1

 FINISHED 
... ated in 2003 by scientists of five European centres of excellence (the Max Planck Institute for Infection Biology in Berlin, the CMMI at Imperial College in London, the Institut Pasteur in Paris, the Karolinska Institutet in Stockholm; and the vaccine company Novartis in Siena). By building a strong coalition among these institutes, EIMID aims at setting the basis for a future no-wall European Ins ...
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 7

 FINISHED 

Human iPS cell therapy for spinal cord injury (human iPS in SCI)

Start date: 03 Oct 2011, End date: 02 Oct 2013,

... antly contribute and add novel and multidisciplinary competencies to my profile as research fellow, developing my skills as a valid and independent European researcher. The cultural exchange with Karolinska Institutet will allow me to gain knowledge and skills in human neural stem cell, iPS techniques, SCI in vitro and in vivo models as well as in the field of biomaterial engineering. In addition, ...
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 1

 FINISHED 
... us. The use of PAH mixtures is motivated by the increasing interest by the European community in developing strategies for risk assessment of complex mixtures. The proposed project will take place at Karolinska Institutet, Sweden, ranked as one of the world’s leading biomedical universities with a strong European dimension, thus an excellent host in pursuing my Europe-oriented career plans."
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 1

 ONGOING 
... ation Core will comprise four integrated laboratories: University of Oxford’s Structural Genomics Consortium laboratory, led by Chas Bountra (OXF-SGC), ETH in Zurich (ETHZ), led by Ruedi Aebersold, Karolinska Institutet (KI-MBB), led by Susanne Gräslund, and the University of Toronto’s SGC laboratory (UTOR-SGC, will not receive IMI funds), led by Cheryl Arrowsmith, and chemical biology teams in Ba ...
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 10

 FINISHED 

TWINNING ON DNA-BASED CANCER VACCINES (VACTRAIN)

Start date: 01 Jan 2016, End date: 31 Dec 2018,

... s” with application to immunotherapy of cancer through building an up-rising connections with two internationally leading research institutions, Institute of Microbiology, Tumor and Cell Biology, Karolinska Institutet (Sweden) and the Department of General Biophysics, University of Lodz (Poland). Both represent centers of excellence in the design, testing and clinical applications of a wide class ...
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 4

 FINISHED 
... ealth-related research and innovation institutions from CSEE. This long-term science and innovation strategy will be achieved by establishing a partnership between leading scientific institutions the Karolinska Institutet and the European Bioinformatics Institute on the one hand and the Consortium of teaching, research and health institutions and SMEs from Slovenia with partners from other low per ...
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 3

 FINISHED 

DNA Origami for drug delivery (VECTORIGAMI)

Start date: 01 Jun 2015, End date: 31 May 2017,

... s of scientific areas such as fluorescence and nanotechnology as well as a background in molecular and cell biology. Complementarily, the host institution, the Department of Neuroscience at Karolinska Institutet, and Björn Högberg’s laboratory in particular, will provide the necessary knowledge on DNA nanotechnology. Högberg’s group has recently established itself as one of the leading DNA-nanotec ...
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 1

 FINISHED 
... . The final purpose is to advance the candidate’s professional competence as an independent researcher and the integration of this knowledge and continuing of this research back upon returning to Karolinska Institutet (KI). To fulfill the aims listed above, Dr. Reisa Sperling, M.D., M.MSc. will serve as the Primary Mentor for the candidate. Dr. Sperling serves as the Principal Investigator (PI) of ...
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 1

 FINISHED 
... GMP-compatible stereo-selective synthesis of an appropriate Vacquinol-1 isomer for amending composition of matter to patent and pre-GLP/GLP toxicological and phase I clinical trials. 4) Together with Karolinska Institutet Innovations AB protect the intellectual property, validate commercialization potential and establish a development plan.
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 1

 FINISHED 
... ophysics, virtual reality, computational modeling and programming as well as a background in electrical engineering that makes her uniquely suited to carry out this project. Additionally, the Karolinska Institutet, the Department of Neuroscience, and in particular Prof. Henrik Ehrsson will provide valuable theoretical knowledge in sensorimotor control as well as technical expertise in neuroimaging ...
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 1

 FINISHED 

The biological clock and cancer (CANCERTIME)

Start date: 01 Feb 2011, End date: 31 Jan 2014,

... both in vitro, using cell lines, and in vivo, by inoculating healthy mice with manipulated tumors. In a final step, in the return phase of the grant I will work together with Dr. Selivanova at the Karolinska Institutet in Stockholm, Sweden where I will test how potential anticancer drugs interact with the circadian clock and the apoptosis pathway."
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 1

 FINISHED 
... pert in the effective communication and dissemination of research results who demonstrate essential complementarity in successfully reaching different target groups. CommFABnet is led by Karolinska Institutet who has initiated and maintained the informal CommNet network of communication managers in the food safety research since 2006. This highly relevant experience will be fully exploited in t ...
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 5

 ONGOING 

Crimean-Congo Haemorrhagic Fever Vaccine (CCHFVaccine)

Start date: 01 Jan 2017, End date: 31 Dec 2022,

Natural epidemics and outbreaks of emerging viral epidemics are growing problems internationally. The general aim of the CCHFVaccine project is to develop and deliver a vaccine, which can significantly increase our capacity to control the situation of Crimean Congo Haemorrhagic fever (CCHF) disease on a global basis. The proposed work program on CCHF virus aims to build a multidisciplinary researc ...
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 15

 ONGOING 
In human cells, two meters of DNA sequence are compressed into a nucleus whose linear size is five orders of magnitude smaller. Deciphering how this amazing structural organization is achieved and how DNA functions can ensue in the environment of a cell’s nucleus represent central questions for contemporary biology.Here, I embrace this challenge by establishing a comprehensive framework of microsc ...
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 1

 ONGOING 
Histone proteins provide a dynamic packaging system for the eukaryotic genome. Chromatin integrates a multitude of signals to control gene expression, only some of which have the propensity to be maintained through replication and cell division. For our understanding of cellular memory and epigenetic inheritance we need to know what features characterize a stable, heritable chromatin state through ...
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 1

 ONGOING 
Sudden cardiac arrest (SCA) causes ~20% of all deaths in Europe. SCA is lethal within minutes if left untreated and survival rates are presently only 5-20%. Therefore, there is a large medical need to improve SCA prevention and treatment. Designing effective individualized prevention and treatment strategies requires knowledge on genetic and environmental risk factors. So far, these efforts have b ...
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 17

 ONGOING 
The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations.MultipleMS will therefor ...
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 25

 ONGOING 
The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemi ...
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 43

 ONGOING 
At least 10% of mothers and 5% of fathers have a mental illness. Family, educational and social lives of children and adolescents with parental mental illness (CAPRI) are disrupted by deprivation and repeated hospitalisation. This is an urgent political and public health concern. The Child and Adolescent Mental Health in Europe (CAMHEE) report urges us ‘to acknowledge and attend to the needs of ch ...
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 2

 ONGOING 
It is now well established that new neurons are added to certain regions of the adult brain. There is today considerable interest in the development of regenerative therapies based on modulating endogenous neurogenesis, but it is necessary to better understand these events to assess whether this is rational and realistic. This application takes its initiation in two recent discoveries that we have ...
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 1

 ONGOING 
Tumor suppressor genes such as TP53, RB1, PTEN and APC are frequently inactivated in sporadic and inherited human tumors. A significant fraction of the mutations in these genes are nonsense mutations that lead to premature termination of translation and expression of truncated unstable and non-functional proteins. We will identify and characterize novel molecules that can induce translational read ...
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 1

 ONGOING 
Oligodendrocytes (OL) are glial cells that mediate myelination of neurons, a process that is defective in multiple sclerosis (MS). Although OL precursor cells (OPCs) can initially promote remyelination in MS, this regenerative mechanism eventually fails in progressive MS. OPCs go through several epigenetic states that ultimately define their potential to differentiate and myelinate. OPCs in progre ...
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 1

 ONGOING 
Oxidative damage and defects in DNA repair are frequently underlying many diseases, e.g., cancer, autoimmune diseases, ischemia/reperfusion injury, neurodegenerative disorders, viral diseases and ageing. Although some molecular understanding into oxidative DNA lesions and repair proteins exist, a thorough understanding on the link to diseases is largely missing, and therapies exploiting oxidative ...
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 1

 ONGOING 
Locomotion is a complex motor act that is used in many daily life activities and is the output measures of a plethora of brain behaviors. The planning and initiation of locomotion take place in the brain and brainstem, while the execution is accomplished by activity in neuronal networks in the spinal cord itself. Recent experiments have provided significant insight to the organization of the execu ...
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 1

 ONGOING 
Immune systems are highly variable, but the sources of this variation are poorly understood. Genetic variation only explains a minor fraction of this, and we are unable to accurately predict the risk of immune mediated disease or severe infection in any given individual. I recently found that immune cells and proteins in healthy twins vary because of non-heritable influences (infections, vaccines, ...
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 1

 ONGOING 
Stomach cancer is the 4th most common cancer and 2nd leading cause of cancer-related death worldwide. The aim of this proposal is to deepen the understanding of mechanisms involved in microbe-induced gastric carcinogenesis, which will facilitate risk stratification for identification of high-risk groups and may offer new opportunities for pharmacological and probiotic prevention. We hypothesize th ...
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 1

 ONGOING 
The contribution of cardiovascular disease to human morbidity and mortality continues to steadily increase in our aging European society. In response, extraordinary efforts have been launched to determine the molecular and pathophysiological characteristics of its etiology. The collective work of multiple research groups has uncovered a complex transcriptional and post-transcriptional regulatory m ...
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 1

 ONGOING 

RECAP: Research on European Children and Adults born Preterm (RECAP)

Start date: 01 Jan 2017, End date: 31 Mar 2021,

The project’s overall aim is to improve the health, development and quality of life of children and adults born very preterm (VPT, < 32 weeks of gestation) or very low birth weight (VLBW, < 1500g) – approximately 50 000 births each year in Europe – by establishing an ICT platform to integrate, harmonise and exploit the wealth of data from 20 European cohorts of VPT/VLBW children and adults and the ...
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 21

 ONGOING 
The INFRAFRONTIER RI integrates European Mouse Clinics and the European Mouse Mutant Archive with the common goal to ensure access to mouse models for basic research of human health and disease, and to translate this knowledge into therapeutic approaches for the benefit of the European society. The expanded INFRAFRONTIER2020 network, coordinated by the INFRAFRONTIER GmbH, includes 3 SMEs and is st ...
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 33

 ONGOING 

Paediatric Clinical Research Infrastructure Network (PedCRIN)

Start date: 01 Jan 2017, End date: 31 Dec 2020,

Children’s health is a major societal challenge for Europe and the world, requiring development of paediatric medicines and treatments strategies based on evidence derived from clinical trials demonstrating efficacy and safety in infants and children, rather than on uncritical extrapolation from adult data (over 50 % of the medicines used for children had not been tested in this specific age group ...
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 16

 ONGOING 
Instruct-Ultra aims to advance the scope and efficiency of implementation of Instruct and consolidate the foundations for long-term sustainability. This will be achieved through specific objectives: expand Instruct membership to new Member States and increase global links; engage new user communities; improve efficiencies in service delivery; improve data capture and management; adjust the scale a ...
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 19

 ONGOING 
Screening for vision and hearing disorders in children has shown to be highly effective. EU-directive 16620/11 invites EU-member states to give priority to such screening programmes. Early detection and treatment of a lazy eye (prevalence 3%) prevents lifelong visual impairment. Early detection and treatment of hearing impairment (prevalence 0.15%) prevents delayed speech and language development. ...
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 10

 ONGOING 

TRANSlating the role of Mitochondria in Tumorigenesis (TRANSMIT)

Start date: 01 Jan 2017, End date: 31 Dec 2020,

The consolidation of the knowledge that cancer is not only a genetic, but also a metabolic disease, has led scientists to investigate the intricate metabolic plasticity that transformed cells must undergo to survive the adverse tumor microenvironment conditions, and the contribution of oncogenes and tumor suppressors in shaping metabolism. In this scenario, genetic, biochemical and clinical eviden ...
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 10

 ONGOING 
MMbio will bridge the classically separate disciplines of Chemistry and Biology by assembling leading experts from academia and non-academic partners (industry, technology transfer & science communication) to bring about systems designed to interfere therapeutically with gene expression in living cells. Expertise in nucleic acid synthesis, its molecular recognition and chemical reactivity is combi ...
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 13

 ONGOING 
Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the Eur ...
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 43

 ONGOING 
Pharmacogenomics is the study of genetic variability affecting an individual’s response to a drug. Its use allows personalized medicine and reduction in ‘trial and error’ prescribing leading to more efficacious, safer and cost-effective drug therapy. The U-PGx consortium will investigate a pre-emptive genotyping approach (that is: multiple pharmacogenomic variants are collected prospectively and ...
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 16