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...cientific excellence documented by the track records of the individual investigators, most of whom have worked together in the FP6 EUMITOCOMBAT project, MEET will combine the efforts of leading clinicians with those of more basic oriented groups and will have important implications for the comprehension and treatment of mitochondria-related pathologies"

Mammalian mitochondrial DNA is a closed circular duplex molecule of 16.5 kilobase pairs. The mechanism of mitochondrial DNA replication is controversial. The long-standing model of mammalian mitochondrial DNA replication entails continuous synthesis of the two strands of DNA.More recently, it has been asserted that coupled leading and lagging-strand DNA synthesis is the major mechanism of mammalia ...