1 European Projects Found
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Optimisation of a non-antibody based technology to improve the efficiency of genome-wide analysis of DNA binding sites (BIRA FOR CHIP-CHIP)
Start date: May 1, 2008, End date: Apr 30, 2010,
...is purpose the humanized (codon optimized) bacterial BirA biotin ligase and the target proteins of interest tagged with a biotin acceptor domain of 13 amino acid residue will be co-expressed in mammalian cells. This will provide the high-specific immuno-precipitation of in vivo biotinylated proteins with their DNA binding sites by strong biotinstreptavidin interaction.This approach can be scaled u ...
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