Search for European Projects

19 European Projects Found

Searched on 125080 European Projects

 FINISHED 

ORTHOpedic randomized clinical trial with expanded bone marrow MSC and bioceramics versus autograft in long bone nonUNIONs (ORTHOUNION)

Start date: Jan 1, 2017, End date: Dec 31, 2021,

Current orthopaedic treatments permit spontaneous bone regeneration to unite and heal 90% bone injuries. Non-union associates pain and disability, often requiring biological enhancement. Regenerative medicine research suggests to the general public that alternative treatments based on advanced therapy medicinal products (ATMP) are already available. However, early clinical trials only explore its ...
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 13

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Clinical trial of autologous adipose-derived mesenchymal stromal cells (ASC) in the treatment of mild to moderate osteoarthritis (ADIPOA2)

Start date: Jan 1, 2015, End date: Dec 31, 2018,

Osteoarthritis (OA) is an incurable disease that has evaded pharmacological interference, biologic therapy or surgical intervention to prevent disease progression. Currently, OA is designated the 11th highest contributor (of 291 diseases) of global disability. In the absence of effective treatment options, cellular therapies using mesenchymal stem/stromal cells (MSCs) have emerged as potential can ...
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 20

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EURO EWING Consortium – International Clinical Trials to Improve Survival from Ewing Sarcoma (EEC)

Start date: Oct 1, 2013, End date: Sep 30, 2018,

Ewing Sarcomas (ES) are fatal, rare bone cancers particularly affecting young people. About 60% of patients achieve long term survival with current treatment but there has been no improvement in this proportion for 25 years. Treatment is unsuccessful because chemotherapy fails to prevent the development of, or to effectively treat established, metastases. In addition, of the 600 new cases of ES o ...
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 21

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implementAtion anD OPeration of the gateway for healTh into BBMRI-ERIC (ADOPT BBMRI-ERIC)

Start date: Oct 1, 2015, End date: Sep 30, 2018,

"BBMRI-ERIC: the Biobanking and BioMolecular resources Research Infrastructure - European Research Infrastructure Consortium, aims to establish, operate and develop a Pan-European distributed research infrastructure in order to facilitate the access to biological resources as well as facilities and to support high quality biomolecular and biomedical research. The ADOPT BBMRI-ERIC proposal aims at ...
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 22

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European Clinical trials in Rare Sarcomas within an integrated translational trial network (EUROSARC)

Start date: Dec 1, 2011, End date: Nov 30, 2016,

Sarcomas are rare malignant tumors, with an overall incidence of 6/105/year. Bone and soft tissue connective tissue tumours encompass more than 50 different rare histotypes and more than 150 different molecular subtypes. The incidence of individual rare sarcomas subtypes is often less than 0.5/105/year. Given sarcoma rarity as a group, but even more as individual entities, few prospective clinical ...
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 22

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Cloud based Simulation platform for Manufacturing and Engineering (CloudSME)

Start date: Jul 1, 2013, End date: Mar 31, 2016,

Simulation can significantly improve the competitive position of manufacturing and engineering companies by reducing their costs and resulting in more efficient development, production, procurement, logistics or financial processes. However, the take-up of simulation software by SMEs has until now been low due to high barriers of entry that include hardware prices, licensing costs and technical ex ...
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 29

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Bioreactor-based, clinically oriented manufacturing of engineered tissues (BIO-COMET)

Start date: Dec 1, 2011, End date: Nov 30, 2015,

Despite significant achievements in the field of regenerative medicine and the enormous potential for engineered tissue products, significant hurdles have prevented cellular therapies from gaining wide-spread clinical adoption. Manufacturing related issues have been proposed as key challenges to be addressed for the translation of regenerative therapies to the clinic and the successful commerciali ...
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 9

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Regenerating Bone defects using New biomedical Engineering approaches (REBORNE)

Start date: Jan 1, 2010, End date: Jun 30, 2015,

Bone is among the most frequently transplanted tissue with about 1 million procedures annually in Europe. The worldwide market of bone replacement materials is currently estimated at 5 billion € with a 10% annual growth. Despite their considerable disadvantages, including the risk of disease transfer and immunologic rejection, limited supply of bone, costs and complications, allografts and autogra ...
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 24

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Virtual Physiological Human: Sharing for Healthcare - A Research Environment (VPH-Share)

Start date: Mar 1, 2011, End date: May 31, 2015,

VPH-Share will develop the organisational fabric (the infostructure) and integrate the optimised services to (1) expose and share data and knowledge, (2) jointly develop multiscale models for the composition of new VPH workflows, (3) facilitate collaborations within the VPH community. Four flagship workflows (from @neurIST, euHeart, VPHOP, Virolab) provide existing data, tools and models, engage w ...
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 20

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COMPOSITE PHENOTYPIC TRIGGERS FOR BONE AND CARTILAGE REPAIR (OPHIS)

Start date: Sep 1, 2010, End date: Aug 31, 2014,

Osteoarthritis (OA) and osteoporosis (OP) are disabling, degenerative bone diseases with significant economic and societal impacts. The incidence of these conditions increases with age but in recent years the number of younger patients has increased, due mainly to factors related to modern life-styles. The efficiency of current pharmacologic and implant-based solutions are limited and often poorly ...
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 9

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ADIPOSE DERIVED STROMAL CELLS FOR OSTEOARTHRITIS (ADIPOA)

Start date: Jan 1, 2010, End date: Jun 30, 2014,

Osteoarthritis (OA) is a degenerative joint disease for which no efficient therapy is available. The ADIPOA consortium has previously shown that intraarticular injections of stromal cells prevents OA in two different models, but the mechanisms of this chondroprotective effect remains unknown, and the activation of cartilage derived endogenous stem cells is suspected. The participants have experien ...
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 12

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Bone motion Capture from video sequences (BOCAP)

Start date: Jan 31, 2011, End date: Jan 30, 2014,

The analysis of human movements, gathering quantitative information about the musculoskeletal system during the execution of a motor task, plays a fundamental role for the understanding of the system physiopathology. Current methods for capturing accurate 3D human motion require the attachment of devices like markers, fixtures or sensors, that may influence the execution of natural movements, requ ...
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 1

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Digitally Integrated Scientific Data for Patients and Populations in User-Specific Simulations (DISCIPULUS)

Start date: Oct 1, 2011, End date: Jun 30, 2013,

The DISCIPULUS SA aims at the grand challenge of the 'Digital VPH Patient'. It is an avatarof the models and individual data that allow health prediction and disease treatment whenthe 'Digital Me' of a citizen needs to avail itself of health services. In essence, it constitutes arevolutionary Clinical Prediction and Decision Support System. To realise this vision,DISCIPULUS develops a sound ICT re ...
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 5

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VPHOP-SIMBIOS cooperation: Tools to develop the NeuroMusculoSkeletal Physiome (NMS Physiome)

Start date: Jan 1, 2010, End date: Jun 30, 2013,

The musculoskeletal apparatus is probably the organ system where the need for the integrative approach advocated by the Virtual Physiological Human (VPH) initiative is most pronounced. The neuromotor control involves the entire body, whereas the processes involved in muscle twitching, bones and muscle adaptation, musculoskeletal aging, and in most musculoskeletal diseases take place at the molecul ...
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 6

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Virtual Physiological Human Network of Excellence (VPH NoE)

Start date: Jun 1, 2008, End date: May 31, 2013,

Description The Virtual Physiological Human Network of Excellence (VPH NoE), 2008-2013, served as a rallying point and source of best-practice information for the VPH community.  This role has now has been passed to the VPH Institute (http://www.vph-institute.org/).  The tools and educational/outreach materials developed by the VPH NoE – and ...
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 23

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Enhanced patient safety by computational Modelling from clinically available X-rays to minimise the risk of overload and instability for optimised function and joint Longevity (MXL)

Start date: Jan 1, 2010, End date: Dec 31, 2012,

Osteorthritis (OA) is a disabling disease, affecting the joints of 40% or more of the population over 60, resulting in a socioeconomic burden of €7b. per year in Germany alone. Joint surgery attempts to address the various disease stages, to either minimize the risk of early degeneration of the native joint, or to replace a fully degenerated joint, with well over 1,000,000 surgeries performed annu ...
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 10

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Osteoporotic Virtual Physiological Human (VPHOP)

Start date: Sep 1, 2008, End date: Oct 31, 2012,

Nearly four million osteoporotic bone fractures cost the European health system more than 30 billion Euro per year. This figure could double by 2050. After the first fracture, the chances of having another one increase by 86%. We need to prevent osteoporotic fractures. The first step is an accurate prediction of the patient-specific risk of fracture that considers not only the skeletal determin ...
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 21

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Future and Emerging Technologies for the Virtual Physiological Human (VPH-FET)

Start date: Sep 1, 2010, End date: Sep 30, 2011,

The Virtual Physiological Human (VPH) is an initiative, supported by the European Commission, to create a computational framework to facilitate the understanding of the integrative function of molecules, cells, tissues, and organisms and, by this, to construct a multiscale in silico model of the human physiology.Specific Calls within Framework 7 have addressed the VPH, and the first set of VPH pro ...
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 2

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Integrating outcome registers, retrieval analysis programs and preclinical validation methods into a synergistic post-marketing surveillance program for orthopedic devices (ORTHOWATCH)

Start date: Jun 6, 2008, End date: Jun 5, 2010,

There is increasing demand for technology to maintain the mobility of an aging worldwide population. Joint replacement is widely recognized as a successful orthopaedic surgical procedure for treating degenerative musculoskeletal conditions. However, joint replacement prostheses have limited longevity, especially in younger and more active people. Efforts to improve prosthesis longevity and perf ...
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 1