2 European Projects Found
Searched on 125080 European Projects
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Elucidating the Role of Phosphorylation by Polo-like kinases in Modulating Alpha-Synuclein Aggregation and Toxicity in Parkinson's disease and Related Disorders (Plks in PD)
Start date: May 1, 2009, End date: Apr 30, 2011,
Increasing evidence suggest that alpha-synuclein (a-syn) phosphorylation plays an important role in the regulation of a-syn aggregation, Lewy Bodies (LBs) formation and neurotoxicity in Parkinson’s disease (PD) and related synucleopathies. However, the exact kinase(s) responsible for phosphorylating a-syn and the relationships between phosphorylation, a-syn fibrillogenesis, LB formation and cell d ...
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Semisynthesis of caged a-Syn (semisynthesis)
Start date: May 1, 2009, End date: Jun 30, 2009,
The overall objective of this proposal is to determine the effect of specific disease associated post-translational modifications, more specifically phosphorylation and nitration, on modulating the structural and biochemical properties of a-synuclein. In detail, we plan to assess the effect of these modifications on i) the structure of monomeric and membrane bound a-synuclein; ii) the oliogmerizat ...
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