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16 European Projects Found

Searched on 125080 European Projects

 FINISHED 

Noise in gene expression as a determinant of virulence of the human pathogen Streptococcus pneumoniae (PneumoCell)

Start date: Nov 1, 2013, End date: Oct 31, 2018,

Not all cells in bacterial populations exhibit exactly the same phenotype, even though they grow in the same environment and are genetically identical. One of the main driving forces of phenotypic variation is stochasticity, or noise, in gene expression. Possible molecular origins contributing to noise in protein synthesis are stochastic fluctuations in the biochemical reactions of gene expression ...
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European Lead Factory (EUC²LID)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

The European Lead Factory concept proposed by the EUC2LID Consortium relates to the discovery of novel small molecule candidates to serve as starting points for subsequent optimization to either drug candidates or high-quality pharmacological tools for the experimental validation of targets. The concept intends to bridge academic and applied research interests. The European Lead Factory will provi ...
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 34

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Self replication in dynamic molecular networks (REPLI)

Start date: Sep 1, 2011, End date: Feb 28, 2017,

"Self-replicating molecules have most likely played an important role in the origin of life. This proposal explores the use of dynamic combinatorial chemistry for identifying new self-replicating molecules. We will make dynamic combinatorial libraries of macrocyclic molecules of different ring sizes that can exchange building blocks through reversible covalent chemistry. The building blocks are eq ...
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 1

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Quantum Optics with Spins in Solid State: The Power of Ensembles (SolidSpinQopt)

Start date: Feb 1, 2012, End date: Jan 31, 2017,

Quantum states of optical pulses can be controlled with great accuracy, and in solid state precise control over quantum states of spins has been achieved. Conversion of such optical quantum states into spin quantum states, and vice versa, is highly relevant for quantum information science, but appears to be more challenging. This proposal aims at a study of such quantum-state conversion, and at de ...
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 1

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Shedding light on catalyst systems for a brighter future with green oxidation chemistry (SolCat)

Start date: Nov 1, 2011, End date: Oct 31, 2016,

Sustainability in chemical synthesis requires that new methods and replacements for unsustainable existing methodologies should, where possible, focus on environmentally benign, atom- and energy-efficient processes that do not rely on toxic/precious metals. In this research program the focus is on the development of new sustainable and environmentally benign methodologies for selective oxidative t ...
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 1

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Unveiling first light from the infant Universe (firstlight)

Start date: Oct 1, 2010, End date: Sep 30, 2016,

I request ERC funding to set up a dedicated science team to detect, for the first time, the redshifted 21-cm radio line emission of neutral hydrogen (HI) with LOFAR coming from the first billion years of the age of the Universe (the Epoch of Reionization and the Dark Ages ).The study of this pristine neutral hydrogen gas is a rapidly emerging field of astrophysics, both theoretically and observ ...
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 1

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Modular Assembly of DNA-based systems; bio-inspired artificial allosteric assemblies (MADNA)

Start date: Sep 1, 2011, End date: Aug 31, 2016,

"Artificial allosteric systems, i.e. (semi-)synthetic systems that give an autonomous response to changes in their environment, are of great interest for applications as sensors, drug delivery and drug targeting.The overall aim of this proposal is the development of bio-inspired DNA-based artificial allosteric systems that are of interest for biological and bio-medical applications.In the present ...
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 1

 FINISHED 

Replication and Adaptation in Molecular Networks (READ)

Start date: Jan 1, 2012, End date: Dec 31, 2015,

"Systems Chemistry (the chemistry of complex mixtures of interacting molecules) is a rapidly developing new fronteir in the chemical sciences. Where chemistry has for centuries been a firmly reductionistic science, Systems Chemistry breaks with this tradition by focussing on complexity and emergent behaviour.This network brings together nearly all major academic players active in Europe on experim ...
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 10

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Dynamical imprints of the evolutionary history of the Milky Way (GALACTICA)

Start date: Jan 1, 2010, End date: Dec 31, 2015,

Galactic Astronomy is entering a new era, driven by state-of-the-art instrumentation and large surveys, and by the dramatic leaps in our understanding of galaxy formation provided by the cosmological LCDM framework. These surveys have shown that the Galaxy is up for discoveries every single month, and have revealed the first footprints of past mergers. This Era will reach its summit when the Gaia ...
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 1

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Bridging Between Organocatalysis and Biocatalysis: The Powerful Enamine Mechanism of Organocatalysts Engineered into the Tautomerase Superfamily Scaffold (Prozymes)

Start date: May 1, 2010, End date: Apr 30, 2015,

Proline and related secondary amines were found to be efficient organocatalysts of aldol, alkylation, Michael addition, and other challenging bond-forming reactions. The design of even more efficient systems that would allow extending this remarkable catalytic strategy to a useful and environmentally benign synthetic methodology would be highly desirable. This proposal aims to develop a new class ...
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 1

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Catalytic Asymmetric C-C bond formation with Organo-Lithium reagents (Cat. Asymm. Lithium)

Start date: Oct 1, 2012, End date: Sep 30, 2014,

Carbon–carbon bond formation is at the hearth of chemistry and the development of new methodology for catalytic enantioselective C-C bond formation continues to be a major challenge for synthesis. After more than 80 years since the introduction of organolithium reagents, no general, highly enantioselective and practical catalytic C-C bond formation with organolithium reagents exists. In preliminar ...
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 1

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Dynamic Combinatorial Chemistry at Lipid Membranes (DynaMem)

Start date: May 21, 2012, End date: May 20, 2014,

Molecular recognition at bilayer membranes is key to many vital processes in biology, yet notoriously difficult to study. Aim of this project is to introduce a new technique to this field: dynamic combinatorial chemistry. We propose to adapt reversible thioester chemistry to this end and use it for two different purposes:(i) Discovering new synthetic receptors that are optimized for operating at t ...
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 1

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What is the molecular mechanism of mechanosensation? Mechanosensitive channel of large conductance, MscL, as a model (MECHANOSENSATION)

Start date: Sep 1, 2008, End date: Feb 28, 2014,

“Equipped with his five senses, man explores the universe around him and calls the adventure science” E.P. Hubble It is amazing how much we have learned about the working of our universe by using our five senses and how little we still know about the working of these senses themselves! Even though the molecular mechanism of sight, taste, and smell is known, we still don’t know how the mechanical s ...
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 1

 FINISHED 

Molecular Motors - Controlling movement at the nanoscale (MOLECULAR MOTORS)

Start date: Jan 1, 2009, End date: Dec 31, 2013,

The design of artificial molecular motors and machines is one of the major challenges in contemporary molecular sciences and bottom-up molecular nanotechnology. Whereas the protein-based molecular motors found in the living cell are amongst the most fascinating and complex structures found in nature and crucial to nearly every key biological process, the field of synthetic linear and rotary motors ...
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 1

 FINISHED 

Asymmetric Aza-Michael reactions catalyzed by hybrids metal-DNA (AMmDNACAT)

Start date: Jul 1, 2011, End date: Jun 30, 2013,

This project deals with the development of new asymmetric reactions catalyzed by metal-DNA hybrids in aqueous medium. The present proposal has two main features:(i) The first feature lies on the design of novel catalytic systems putting into practice the concept of DNA-based asymmetric catalysis presented in the year 2005 by Ben. L. Feringa and G. Roelfes. This methodology involves the modular ass ...
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 1

 FINISHED 

Self-Replication in Dynamic Combinatorial Libraries (DynaRep)

Start date: Feb 1, 2011, End date: Jan 31, 2013,

The host group has recently made a remarkable discovery: the spontaneous emergence of self-replicating molecules from a complex mixture of continuously interconverting peptide-derived compounds (dynamic combinatorial libraries). This project builds on this discovery and aims to come to a complete understanding of the mechanism of replication. Based on this understanding new replicators will then b ...
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