Search for European Projects

14 European Projects Found

Searched on 125080 European Projects

 FINISHED 

A multicenter phase IIb study using HLA-unmatched allogeneic placenta-derived stromal cells (PLX-PAD) for the treatment of severe critical limb ischemia accompanied by mechanistic studies (PACE)

Start date: Jan 1, 2017, End date: Dec 31, 2020,

PACE aims to transform the treatment of patients suffering from critical limb ischemia (CLI), a disease with high medical need, because of limited treatment options and poor outcome by applying a novel, off-the-shelf allogeneic placenta-derived stromal cell product (PLX-PAD). Despite improvements in medical care and revascularization, patients with CLI continue to have a high risk of major amputat ...
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 9

 FINISHED 

Massive Reverse Genomics to Decipher Gene Regulatory Grammar (MRG-GRammar)

Start date: Aug 1, 2015, End date: Jul 31, 2018,

MRG-GRammar aims to devise an entirely new strategy for deciphering the regulatory rules of gene regulation. We will leverage Synthetic Biology with cutting-edge DNA synthesis technologies and high-throughput analysis to generate new types of biological datasets that systematically explore all possible regulatory landscapes rather than just the naturally occurring regulatory sequences. The extensi ...
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 7

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BBMRI - Large Prospective Cohorts (BBMRI-LPC)

Start date: Feb 1, 2013, End date: Jan 31, 2017,

...samples and data;4)Provide free transnational access by users, through study proposals selected by an open, pan-European call;5)In the framework of these studies, generate and provide access to whole genome sequences, transcriptome, proteome, metabolome and methylome data;6)Build new public-private partnerships involving large-scale prospective cohorts, and strengthening existing ones, allowing tr ...
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 36

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European Bank for induced pluripotent Stem Cells (EBISC)

Start date: Jan 1, 2014, End date: Dec 31, 2016,

EBiSC is designed to address the increasing demand by iPSC researchers for quality-controlled, disease-relevant research grade iPSC lines, data and cell services. Its goal is to demonstrate an operational banking and distribution service of iPSC lines after 3 years and to establish subsequently for Europe a centralised, not-for-profit bank providing all qualified users with access to scalable, cos ...
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 30

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OncoTrack - Methods for systematic next generation oncology biomarker development (ONCOTRACK)

Start date: Jan 1, 2011, End date: Dec 31, 2016,

We propose here an exhaustive analysis of the genome, exome, methylome and transcriptome of primary tumours and metastases from patients with colon carcinoma, based on a combination of deep sequencing and chip based techniques. Dependent on their availability, we shall also perform analyses of tumor stem cells, circulating tumor cells, free tumor DNA in serum and xenografts derived from the same p ...
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 22

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A BLUEPRINT of Haematopoietic Epigenomes (BLUEPRINT)

Start date: Oct 1, 2011, End date: Sep 30, 2016,

In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and o ...
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 45

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Genetic and Epigenetic Networks in Cognitive Dysfunction (GENCODYS)

Start date: May 1, 2010, End date: Apr 30, 2015,

Mutations in about 400 different genes have been associated with Cognitive Disorders (CD), such as mental retardation, autism, neurodegenerative disorders, and psychiatric disorders. Whereas CD impose a major medical and socio-economical problem, there are no systematic studies that aim to provide insight into common mechanisms in CD. We propose a systems biology approach to gain insight into comm ...
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 15

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Synaptic Systems: dissecting brain function in health and disease (SYNSYS)

Start date: Jul 1, 2010, End date: Dec 31, 2014,

Major disorders of the Central Nervous System (CNS) affect one in three people in the developed world, often seriously disable the affected individual, and together account for the single largest burden on the healthcare systems of the EU. Most of these disorders act at the neuronal synapse, a cellular organelle comprising in the order of 2000 proteins. Pleiotropy, cross-talk between proteins and ...
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 19

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European Consortium on Synaptic Protein Networks in Neurological and Psychiatric Diseases (EUROSPIN)

Start date: Jan 1, 2010, End date: Jun 30, 2014,

"Signalling at nerve cell synapses - a key determinant of all aspects of brain function - depends on the function of hundreds of synaptic proteins and their interactions. Numerous recent studies showed that a wide range of neurological and psychiatric diseases are 'synaptopathies' whose onset and progression are due to mutations of synaptic proteins and subsequent synaptic dysfunctions. EUROSPIN w ...
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 19

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Sharing capacity across Europe in high-throughput sequencing technology to explore genetic variation in health and disease (GEUVADIS)

Start date: Oct 1, 2010, End date: Dec 31, 2013,

"High-throughput next-generation DNA sequencing technologies allow investigators to sequence entire human genomes at an affordable price and within a short time frame. The correct interpretation, storage, and dissemination of the large amount of produced genomics data generate major challenges. Tackling these challenges requires extensive exchange of data, information and knowledge between medical ...
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 17

 FINISHED 

European Network for Genetic and Genomic Epidemiology (ENGAGE)

Start date: Jan 1, 2008, End date: Dec 31, 2012,

...ypic data already available from a substantial number of large and well-characterised European (and other) sample sets of various types. The initial focus will be an integrated analysis of >80,000 genomewide association scans available to the consortium, thereby identifying the large number of novel disease-susceptibility variants undetectable in individual studies. Early studies will concentra ...
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 26

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IT Future of Medicine (ITFoM)

Start date: May 1, 2011, End date: Apr 30, 2012,

Data-rich, individualised medicine poses unprecedented challenges for IT, in hardware, storage and communication. We propose a data-driven, individualised medicine of the future, based on molecular/physiological/anatomical data from individual patients. We shall make general models of human pathways, tissues, diseases and ultimately of the human as a whole. Individualised versions of the models, ...
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 25

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Optimisation of a non-antibody based technology to improve the efficiency of genome-wide analysis of DNA binding sites (BIRA FOR CHIP-CHIP)

Start date: May 1, 2008, End date: Apr 30, 2010,

Development of genome wide tools to study regulatory elements is particularly important to understand how gene expression is controlled in the human genome. The rational study of transcription factors and DNA-binding proteins in sequenced human genome is critical for making the genome sequences maximally useful.Chromatin Immuno-Precipitation (ChIP) materials analysed on microarrays for specific in ...
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 2

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ScanBalt Campus – a European model case for transnational and transectoral institution building in education, research and development. (ScanBalt Campus)

Start date: Mar 9, 2005, End date: Jun 8, 2007,

The basic concept of ScanBalt Campus is to deliver a framework for joint activities within ScanBalt Bioregion in knowledge formation and innovation and to increase the visibility of these actions. An important feature of ScanBalt Campus is that despite its focus on Biotech/life sciences, all activities should reflect a holistic view. This means that the educational training should also encompass a ...
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 31