3 European Projects Found
Searched on 125080 European Projects
FINISHED
Chromatin and MetabolismChromatin-metabolism interactions as targets for healthy living (ChroMe)
Start date: Mar 1, 2016, End date: Feb 29, 2020,
Metabolic disorders are at pandemic levels. Based on recent estimates, ~50% of Europeans are overweight, 20% are obese and 10% have type II diabetes. Obesity and insulin resistance impact European health to the tune of €110 billion per year. These disorders have genetic, nutritional and lifestyle causes. However, the molecular mechanisms that link nutrients and lifestyle to gene activity and chrom ...
Read Project
12
Partners Participants
FINISHED
Cell of origin/Leukemia Initiating Cell in infant Pro-B MLL-AF4+ ALL (MODELING MLL-AF4 ALL)
Start date: May 1, 2014, End date: Apr 30, 2018,
"Infant pro-B acute lymphoblastic leukemia (ALL) carrying the fusion oncogene MLL-AF4 is associated with very brief latency and dismal prognosis. Recent studies have revealed an in utero origin of MLL-AF4 but the nature of the target cell for transformation in the embryo/fetus is unknown. Because of the mixed phenotype and the presence of MLL-AF4 in both lymphoid and myeloid lineages, hematopoieti ...
Read Project
1
Partner Participant
FINISHED
GENOMIC, CELLULAR AND DEVELOPMENTAL RECONSTRUCTION OFINFANT MLL-AF4+ ACUTE LYMPHOBLASTIC LEUKEMIA (INFANTLEUKEMIA)
End date: Jan 1, 2016,
Infant cancer is very distinct to adult cancer and it is progressively seen as a developmental disease. An intriguing infant cancer is the t(4;11) acute lymphoblastic leukemia (ALL) characterized by the hallmark rearrangement MLL-AF4 (MA4), and associated with dismal prognosis. The 100% concordance in twins and its prenatal onset suggest an extremely rapid disease progression. Many key issues rema ...
Read Project
