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Mechanism of BVDV fusion (PESTIVIRUS FUSION)

Start date: Sep 1, 2007, End date: Aug 31, 2009,

Increasing evidence suggested that BVDV glycoprotein E2 belongs to the class II viral fusion proteins like flavivirus E and alphavirus E1 protein. In spite of further similarities in entry pathways of BVDV and flavi- and alphaviruses, recently a fundamental difference in the initiation of fusion process was reported.While flavi- and alphavirus fusion is initiated upon environmental acidification, ...
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