6 European Projects Found
Searched on 125080 European Projects
FINISHED
MEsenchymal stem cells to Reduce Liver INflammation (MERLIN)
Start date: Feb 1, 2014, End date: Jan 31, 2018,
"Prevalence of liver disease is c6% (29 million people) in the EU with mortality rates from chronic liver diseases estimated at 14.3 per 100.000 in the EU-25 in 2004. Most liver diseases have a significant inflammatory component that underpins liver damage and fibrogenesis, yet current therapies have limited effectiveness. Safe novel anti-inflammatory therapies would satisfy a large unmet need for ...
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9
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Advanced Immunization Technologies (ADITEC)
Start date: Oct 1, 2011, End date: Sep 30, 2017,
Vaccines so far have been developed mostly by following an empiric approach. To prevent and possibly cure unresolved and emerging infectious diseases we need to fully exploit the potential of the human immune system. Progress in science and technology makes it possible to achieve what was previously deemed impossible. The scope of this project is to produce knowledge necessary to develop novel and ...
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53
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BeTheCuRE (BTCURE)
Start date: Apr 1, 2011, End date: Mar 31, 2017,
BTCure is based on the recognition that RA is a heterogeneous disease where a major subset involves adaptive immunity, and that animal models have to develop the line with the different subsets of the human diseases in order to be optimally used for drug discovery and drug evaluation. Our aim is to develop an understanding of the early process in human arthritis subsets and the animal models that ...
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41
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TargetIng novel MEchanisms of Resolution in inflammation (TIMER)
Start date: Jan 1, 2012, End date: Dec 31, 2015,
Resolution of inflammation is a key determinant of pathology, and an active process which involves diverse pathways and molecules. The general objective of the TIMER Consortium is to identify and validate new molecules involved in the resolution of inflammation as a basis for the development of innovative therapeutic strategies in chronic inflammatory and autoimmune diseases. The project will invo ...
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13
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Systems Biology of T-cell Activation in Health and Disease (SYBILLA)
Start date: Apr 1, 2008, End date: Sep 30, 2013,
T-cell activation, whether induced by pathogens or auto-antigens, is a complex process relying on multiple layers of tightly controlled intracellular signalling modules that form an intricate network. Defects in this network can cause severe and chronic disorders such as autoimmune diseases. Although 5% of the population suffer from these diseases, only a few therapeutic treatments are available. ...
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22
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Normalisation of immune reactivity in old age – from basic mechanisms to clinical application (TOLERAGE)
Start date: Apr 1, 2008, End date: Sep 30, 2012,
"When restoration of the immune response in older age is the target of basic and clinical research, boosting innate and adaptive immunity, e.g. by more efficient vaccination strategies, is the general approach. However, TOLERAGE has a fundamentally different focus, i.e. restoring the age-dependent decline of auto-tolerance that underlies the development of the paradigmatic age-associated diseases ...
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