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Beta-Secretase (beta-SEC) is responsible for the intramembrane cleavage of amyloid precursor protein, an event intimately linked to Alzheimer's disease (AD). Beta-SEC is an aspartic protease composed by presenilin, nicastrin (NCT), APH-1, and PEN-2.Beta-SEC appears to have a very broad specificity; however, no quantitative data is available to support this assumption. NCT subunit is a type 1 membr ...

The amyloid beta peptide (A-beta) plays a central role in the pathogenesis of Alzheimers disease but it remains unclear how exactly this peptide impacts on neuronal viability and cognitive functions in AD patients.More and more it is believed that synaptic dysfunction and loss caused by small soluble A-beta oligomers, but not by mature fibrils deposited in the plaques, is the first sign of neurode ...