5 European Projects Found
Searched on 125080 European Projects
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Mobile elements: shuffling the regulome in development and disease (EVOLINE)
Start date: Feb 2, 2015, End date: Feb 1, 2018,
The present structure of the human genome is largely a result of the activity of Transposable Elements (TEs) or jumping genes. Indeed, they have constantly provided genomic variability over evolution, resulting in the generation of new genes and new regulatory circuits among others, and they are still doing it now, mainly leaded by the activity of few classes of TEs as LINE-1 retrotransposons.LINE ...
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Generation of human experimental models of Bernard-Soulier Syndrome and Glanzmann Disease using cellular reprogramming (PLATELET DISORDERS)
Start date: Jan 14, 2015, End date: Jan 13, 2017,
Glanzmann's Disease, also known as Glanzmann's thrombasthenia (GT), and Bernard-Soulier syndrome (SBS) are autosomal recessive rare platelet disorders, characterized by severe bleeding because of the absence, reduction or dysfunction of several glycoprotein receptor complexes in platelets. Both normal number and morphology of platelets characterize TG. However, platelet aggregation ability is seri ...
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Role of LINE-1 retrotransposons in the human disease DiGeorge Syndrome (L1-DIGEORGESYNDROME)
Start date: Jun 1, 2012, End date: Nov 21, 2016,
Long INterspersed Element 1 (LINE-1s or L1s) is a highly abundant retrotransposon comprising 17% of the human genome. Most L1s are retrotransposition defective, but there are approximately 100 full-length active L1s (RC-L1s) in an average human genome. The activity of RC-L1s impacts the human genome in a myriad of ways, and several human diseases have been caused by the activity of L1s.The Drosha- ...
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Development and in vivo validation of a SPION based Theranostic nanosystem for the treatment of Metastatic Breast Cancer (MBCtheranosticSPION)
Start date: Oct 28, 2014, End date: Oct 27, 2016,
This project aims to develop a Theranostic Nanosystem allowing selective co-delivery of therapeutic agents with distinct physical chemical properties to target diseased cells in vivo. Besides good on-shelf and in vivo stability and low toxicity, the system must enable ratiometric control of cargo loading, avoid premature release of transported agents, allow controlled drug release at targeted loca ...
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LINE-1 retrotransposition in human somatic cells (SOMATIC_MOSAICISM)
Start date: Jun 12, 2013, End date: Jun 11, 2015,
The human genome is largely composed of non-coding DNA, only 3-5% codes for exons. The majority of the non-coding DNA is however fundamental for the correct functioning and regulation of the genome. Transposable elements (TEs) like LINEs generated up to 50% of the human genome during evolution. They can mobilize, causing mutations but also conferring genomic plasticity. The generation of new inser ...
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