Search for European Projects

13 European Projects Found

Searched on 125080 European Projects

 FINISHED 

An Integrated European ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century (EU-ToxRisk)

Start date: Jan 1, 2016, End date: Dec 31, 2021,

The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemi ...
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 43

 FINISHED 

Muscle Stress Relief: An integrated research program linking together basic research on secondary myopathies in stress states to innovative translation in applied myology. (Muscle stress relief)

Start date: Mar 1, 2016, End date: Feb 29, 2020,

...ires a multidisciplinary approach covering aspects of ageing, metabolism, and on the humoral cross-talk of muscle with other key organs including heart, liver, kidney, and lung. To achieve this, six European groups with complementary expertise in inter-organ-cross-talk during stress-induced secondary myopathies will team-up with a leading team in the U.S. with expertise in the translation of musc ...
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 14

 FINISHED 

Statistical multi-Omics UNDerstanding of Patient Samples (SOUND)

Start date: Sep 1, 2015, End date: Aug 31, 2018,

Bioinformatic analysis is the biggest bottleneck in many genomic medicine projects. Our objective is to enable researchers to dramatically increase statistically informed use of personal multi-omic data in medicine. Soon, multiple types of omic technologies will be applied to 100,000s of patient-derived samples, with the three-stage goal of better understanding disease biology, discovery of new in ...
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 11

 FINISHED 

Early warning signals of ageing in human stem cells and age-related disorders (SYSTEMAGE)

Start date: Jan 1, 2013, End date: Dec 31, 2017,

The regenerative power of a living organism is linked to the potential of its stem cells to replace the corresponding damaged tissue. Therefore organisms are as old as their stem cells. Whereas the vulnerability to cancer and chronic inflammation is associated with a decline of the immune system, the latter is in turn a sum product of interactions among hematopoietic stem cells (HSC), endothelial ...
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 11

 FINISHED 

Non-coding RNAs in neurogenic and neuropathic pain mechanisms and their application for risk assessment, patient stratification and personalised pain medicine (NCRNAPAIN)

Start date: Oct 1, 2013, End date: Sep 30, 2017,

Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs (ncRNAs) regulate both immune and neuronal processes. Therefore, ncRNAPain proposes that ncRNAs are critically important master switches for chronic pain.ncRNAPain represents a multidisciplinary consortium of clinical partners, molecular and systems-level n ...
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 12

 FINISHED 

Peroxisomes: key to cell performance and health (PERFUME)

Start date: Jan 1, 2013, End date: Dec 31, 2016,

The PERFUME (PERoxisome Formation, Function, MEtabolism) program is an interdisciplinary and intersectoral ITN providing state-of-the-art research training at the interface of medicine, plant and fungal biology. The PERFUME S&T specifically aims at unraveling the principles of peroxisome biology.Peroxisomes have been discovered relatively recently (in 1954). Consequently, the level of understandin ...
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 12

 FINISHED 

Infrastructure for Systems Biology - Europe (ISBE)

Start date: Aug 1, 2012, End date: Jul 31, 2015,

The Infrastructure for Systems Biology in Europe (ISBE) programme comprises an infrastructure that is designed to meet the needs of European systems biology, in terms of development, applications and training. In order to address this requirement, we are proposing a distributed, interconnected infrastructure which primarily comprises three types of centres: Data Integration Centres (DICs), and sys ...
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 24

 FINISHED 

A systems biology approach to dissect cilia function and its disruption in human genetic disease (SYSCILIA)

Start date: Jun 1, 2010, End date: May 31, 2015,

AIM: To identify the molecular mechanisms characterizing cilium function, and the discrete perturbations associated with dysfunction caused by mutations in inherited ciliopathies, applying a systems biology approach. BACKGROUND: Cilia are microtubule-based, centriole-derived projections from the cell surface. They transduce extracellular signals and regulate key processes in which signals of the e ...
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 17

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Towards the establishment of a permanent European Virtual Institute dedicated to Malaria Research (EVIMalaR) (EVIMalaR)

Start date: Oct 1, 2009, End date: Mar 31, 2015,

This is a proposal from 55 partners from 36 institutes to form a NoE that will seek to integrate European malaria research that is directed towards a better understanding of the basic biology of the parasite, its vector and of the biology of the interactions between the parasite and both its mammalian host and vectors. All the member institutes and researchers have demonstrated both their excellen ...
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 40

 FINISHED 

Euro-BioImaging - Research infrastructure for imaging technologies in biological and biomedical sciences (Euro-BioImaging)

Start date: Dec 1, 2010, End date: May 31, 2014,

...e human organism. Euro-BioImaging will therefore develop a plan to construct and operate a set of complementary and strongly interlinked infrastructure facilities appropriately distributed across the European member states. To achieve this, Euro-BioImaging will define the legal and governance framework with its currently 22 member states and develop a finance plan in close cooperation with nationa ...
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 44

 FINISHED 

Research capacity for the implementation of genetic control of mosquitoes (INFRAVEC)

Start date: Sep 1, 2009, End date: Feb 28, 2014,

...f mosquito vectors. INFRAVEC aims at bridging the gap between the recent advances in transgenic technology and its implementation as a novel powerful approach for vector control. To this aim, a large European Infrastructure will be established, in which the coordination of efforts, expertise and facilities provided by the individual research groups and institutions will bolster and considerably ex ...
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 31

 FINISHED 

Cis-regulatory logic of the transcriptional control in neural stem cells (CISSTEM)

Start date: Oct 1, 2008, End date: Mar 31, 2012,

"Neural stem cells (NSCs) have emerged as a major topic in neurobiology. The persistence of multipotent cells in the adult mammalian brain offers a realistic chance for the treatment of neurodegenerative diseases. It is thus crucial to understand NSCs from as many as possible angles (e. g. cellular and molecular biology), in order to better isolate and successfully manipulate them. CISSTEM present ...
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 9

 FINISHED 

Genomic screens to identify and characterize mechanisms of mycobacterial killing by Macrophages (MACROPHAGE GENOMICS)

Start date: Oct 1, 2007, End date: Sep 30, 2009,

Non-pathogenic mycobacteria are efficiently phagocytosed by macrophages and killed within phagosomes by acid hydrolases, reactive nitrogen intermediates, and likely other still unidentified factors that are part of the macrophage pro-inflammatory response. In contrast, pathogenic mycobacteria such as M. tuberculosis survive and grow within phagosomes by blocking macrophage pro-inflammatory respons ...
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