7 European Projects Found
Searched on 125080 European Projects
FINISHED
Magnetic DIagnostic Assay for neurodegenerative diseases (MADIA)
Start date: Jan 1, 2017, End date: Dec 31, 2019,
MADIA aims at realizing a versatile and cheap diagnostic device based on magnetoresistive sensors, microfluidic device, ultra–small Magnetic Nanoparticles (MNPs) and advanced bio-chemical functionalization methods for the early and ultrasensitive in vitro detection of biomarkers trustfully associated with 2 incurable neurodegenerative diseases: Alzheimer’s Disease (AD) and Parkinson Disease (PD). ...
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10
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Human Brain Project Specific Grant Agreement 1 (HBP SGA1)
Start date: Apr 1, 2016, End date: Mar 31, 2018,
...bilities of the HBP Platforms, in order to use them to address otherwise intractable problems in neuroscience, computing and medicine in the future. In addition, collaborations with other national, European and international initiatives will create synergies, maximizing returns on research investment. SGA1 covers the detailed steps that will be taken to move the HBP closer to achieving its ambitio ...
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126
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Role of the mitochondrial Translocator Protein (mTSPO) in Brain Cellular Physiology: a Neglected Pathway in Signalling and Self-conservation Mechanisms (TSPO & BRAIN)
Start date: Dec 1, 2012, End date: Jul 2, 2017,
Balanced energy homeostasis and correct functioning of regulatory processes are the basis of cellular health. The impaired interplay between these is thus responsible for the pathology of tissues especially for those undergoing stress and unable to regenerate such as the Brain. An exhaustive comprehension of the physiology of molecules intimately involved in these phenomena is therefore essential ...
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2
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"The NGF system and its interplay with endocannabinoid signalling, from peripheral sensory terminals to the brain: new targets for the development of next generation drugs for neuropathic pain" (PAINCAGE)
Start date: Apr 1, 2014, End date: Mar 31, 2017,
"So far, there are no effective treatments for neuropathic pain (NP), and current treatments suffer from serious unwanted side effects.The NGF ligand-receptor system has recently emerged as a novel target for NP of great therapeutic potential, a master regulator, controlling both neuropathic and inflammatory components. Besides being a multi-component system, it also modulates the endocannabinoid ...
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9
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The Human Brain Project (HBP)
Start date: Oct 1, 2013, End date: Sep 30, 2016,
..., Brain Simulation, High Performance Computing, Medical Informatics, Neuromorphic Computing and Neurorobotics, and create a user community of research groups from within and outside the HBP, set up a European Institute for Theoretical Neuroscience, complete a set of pilot projects providing a first demonstration of the scientific value of the platforms and the Institute, develop the scientific and ...
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116
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Self-Modulating Neurons in the Cerebral Cortex: From Molecular Mechanisms to Cortical Network Activities (CORTEXSELFCONTROL)
Start date: Oct 1, 2008, End date: Mar 31, 2014,
"In the mammalian brain, the neocortex is the site where sensory information is integrated into complex cognitive functions. This is accomplished by the activity of both principal glutamatergic neurons and locally-projecting inhibitory GABAergic interneurons, interconnected in complex networks. Inhibitory neurons play several key roles in neocortical function. For example, they shape sensory recep ...
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2
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“Linking dendritic mRNA metabolism to neuronal functions and disorders” (dendritic mRNAs)
Start date: Feb 1, 2009, End date: Jan 31, 2013,
Synaptogenesis and synaptic plasticity rely on protein synthesis, in particular on localized translation within dendrites. The aim of my project will focus on investigating the multiple and overlapping molecular mechanisms that contribute to fine-tuning the expression of dendritic mRNA at synapses. In my previous work, I have identified a novel regulatory pathway that involves splicing and modulat ...
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