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Exploiting the MSP-AMPK pathway for amelioration of NASH (MANASH)
Start date: Mar 1, 2013, End date: Feb 28, 2015,
"BACKGROUNDNon–alcoholic steatohepatitis (NASH) is the hepatic event of the metabolic syndrome and is characterized by steatosis and inflammation. Although our understanding of the disease mechanisms has progressed, the therapy options for treatment of NASH remain poor. AMP-activated protein kinase (AMPK) is an important integrator of signals managing energy balance and acts as a protective respon ...
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